Nicotinic Cholinergic Cortical Dysfunction in Schizophrenia
Cortical deficits in schizophrenia have been related to diverse psychophysiological, neurobiological, and genetic deficits. This chapter reviews specific psychophysiological deficits in sensory and motor gating, their neurobiological substrate in nicotinic acetylcholine-mediated neurotransmission, and their genetic basis. Detailed correlations between these several levels of observation are necessary to parse schizophrenia into discrete and hopefully more treatable elements.
KeywordsNicotinic Receptor Smooth Pursuit Biol Psychiatry Sensory Gating Cornu Ammonis
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