Advertisement

Nicotinic Cholinergic Cortical Dysfunction in Schizophrenia

  • Jason R. Tregellas
  • Robert Freedman

Cortical deficits in schizophrenia have been related to diverse psychophysiological, neurobiological, and genetic deficits. This chapter reviews specific psychophysiological deficits in sensory and motor gating, their neurobiological substrate in nicotinic acetylcholine-mediated neurotransmission, and their genetic basis. Detailed correlations between these several levels of observation are necessary to parse schizophrenia into discrete and hopefully more treatable elements.

Keywords

Nicotinic Receptor Smooth Pursuit Biol Psychiatry Sensory Gating Cornu Ammonis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jason R. Tregellas
    • 1
  • Robert Freedman
    • 1
  1. 1.Department of PsychiatryUniversity of ColoradoDenverUSA

Personalised recommendations