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Towards a Molecular Classification of Illness: Effects of Schizophrenia Susceptibility Loci on Clinical Symptoms and Cognitive Function

  • Anil K. Malhotra
  • Pamela DeRosse
  • Katherine E. Burdick

Schizophrenia is a complex neuropsychiatric disorder characterized by a myriad of symptoms that include hallucinations, delusions, thought disorganization (or positive symptoms), apathy, avolition, and asociality (or negative symptoms), and cognitive impairment. No single symptom, or symptom cluster, is pathognomonic, and the current classification of the disorder into the Diagnostic and Statistical Manual IV (DSM-IV) (First et al. 1997) subtypes of paranoid, disorganized, catatonic and undifferentiated is solely based upon clinical phenomena.

Keywords

Negative Symptom Positive Symptom Schizoaffective Disorder Risk Haplotype Soft Neurological Sign 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Anil K. Malhotra
    • 1
  • Pamela DeRosse
    • 1
  • Katherine E. Burdick
    • 1
  1. 1.Division of Psychiatry ResearchZucker Hillside HospitalGlen OaksUSA

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