Towards a Molecular Classification of Illness: Effects of Schizophrenia Susceptibility Loci on Clinical Symptoms and Cognitive Function
Schizophrenia is a complex neuropsychiatric disorder characterized by a myriad of symptoms that include hallucinations, delusions, thought disorganization (or positive symptoms), apathy, avolition, and asociality (or negative symptoms), and cognitive impairment. No single symptom, or symptom cluster, is pathognomonic, and the current classification of the disorder into the Diagnostic and Statistical Manual IV (DSM-IV) (First et al. 1997) subtypes of paranoid, disorganized, catatonic and undifferentiated is solely based upon clinical phenomena.
KeywordsNegative Symptom Positive Symptom Schizoaffective Disorder Risk Haplotype Soft Neurological Sign
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