Biosynthesis of Anandamide and 2-Arachidonoylglycerol

  • Takayuki Sugiura

Anandamide (N-arachidonoylethanolamine) can be synthesized from free arachidonic acid and ethanolamine by the action of a fatty acid amide hydrolase acting in reverse or from preexisting N-arachidonoyl phosphatidylethanolamine by the action of a phosphodiesterase (phospholipase D). Evidence is accumulating that anandamide is synthesized mainly by the latter pathway rather than the former in various mammalian tissues and cells. 2-Arachidonoylglycerol can be synthe sized from arachidonic acid-containing diacylglycerol derived from increased inositol phospholipid metabolism by the action of a diacylglycerol lipase. 2-Arachidonoylglycerol can also be formed via other pathways such as the hydrolysis of the diacylglycerol derived from phosphatidylcholine and phosphatidic acid by the action of a diacylglycerol lipase and the hydrolysis of arachidonic acid- containing lysophosphatidic acid by the action of a phosphatase. The relative importance of these pathways may depend on the types of cells and stimuli. In this review, I have summarized the pathways and enzymes involved in the synthesis of anandamide and 2-arachidonoylglycerol.


Fatty Acid Amide Hydrolase Inositol Phospholipid Free Arachidonic Acid Diacylglycerol Lipase N18TG2 Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2008

Authors and Affiliations

  • Takayuki Sugiura
    • 1
  1. 1.Teikyo UniversitySagamikoJapan

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