Cognitive Impairment

  • James M. Noble
  • Nikolaos Scarmeas


Cognitive Impairment Oral Health Alzheimer Disease Periodontal Disease Dementia With Lewy Body 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Active Ageing: A Policy Framework (2002). World Health Organization: 1–60.Google Scholar
  2. Adam, H. and Preston, A. J. (2006). “The oral health of individuals with dementia in nursing homes.” Gerodontology 23(2): 99–105.PubMedCrossRefGoogle Scholar
  3. ADI. (January 25, 2006). “Common Questions.” Retrieved December 11, 2006.Google Scholar
  4. Agrawal, A. A., Kapley, A., Yeltiwar, R. K. and Purohit, H. J. (2006). “Assessment of single nucleotide polymorphism at IL-1A+4845 and IL-1B+3954 as genetic susceptibility test for chronic periodontitis in Maharashtrian ethnicity.” J Periodontol 77(9): 1515–21.PubMedCrossRefGoogle Scholar
  5. Albandar, J. M. (2002). “Periodontal diseases in North America.” Periodontol 2000 29: 31–69.PubMedCrossRefGoogle Scholar
  6. Anderson, D. J. (1956). “Measurement of stress in mastication. I.” J Dent Res 35(5): 664–70.PubMedGoogle Scholar
  7. Arai, K., Sumi, Y., Uematsu, H. and Miura, H. (2003). “Association between dental health behaviours, mental/physical function and self-feeding ability among the elderly: a cross-sectional survey.” Gerodontology 20(2): 78–83.PubMedCrossRefGoogle Scholar
  8. Armitage, G. C. (2000). “Periodontal infections and cardiovascular disease–how strong is the association?” Oral Dis 6(6): 335–50.PubMedCrossRefGoogle Scholar
  9. Aronson, M. K., Ooi, W. L., Geva, D. L., Masur, D., Blau, A. and Frishman, W. (1991). “Dementia. Age-dependent incidence, prevalence, and mortality in the old old.” Arch Intern Med 151(5): 989–92.PubMedCrossRefGoogle Scholar
  10. Babel, N., Cherepnev, G., Babel, D., Tropmann, A., Hammer, M., Volk, H.-D. and Reinke, P. (2006). “Analysis of Tumor Necrosis Factor-α, Transforming Growth Factor-β, Interleukin-10, IL-6, and Interferon-γ Gene Polymorphisms in Patients With Chronic Periodontitis.” J Periodontol 77(12): 1978–83.PubMedCrossRefGoogle Scholar
  11. Beck, J., Garcia, R., Heiss, G., Vokonas, P. S. and Offenbacher, S. (1996). “Periodontal disease and cardiovascular disease.” J Periodontol 67(10 Suppl): 1123–37.PubMedGoogle Scholar
  12. Beck, J. D., Koch, G. G., Rozier, R. G. and Tudor, G. E. (1990). “Prevalence and risk indicators for periodontal attachment loss in a population of older community-dwelling blacks and whites.” J Periodontol 61(8): 521–28.PubMedGoogle Scholar
  13. Beck, J. D. and Offenbacher, S. (2005). “Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease.” J Periodontol 76(11 Suppl): 2089–100.PubMedCrossRefGoogle Scholar
  14. Behle, J. H. and Papapanou, P. N. (2006). “Periodontal infections and atherosclerotic vascular disease: an update.” Int Dent J 56(4 Suppl 1): 256–62.PubMedGoogle Scholar
  15. Bodet, C., Chandad, F. and Grenier, D. (2006). “Porphyromonas gingivalis-induced inflammatory mediator profile in an ex vivo human whole blood model.” Clin Exp Immunol 143(1): 50–57.PubMedCrossRefGoogle Scholar
  16. Brazis, P. W., Masdeu, J. C. and Biller, J. (2001). Cerebral Hemispheres. Localization in Clinical Neurology. Philadelphia, Lippincott Williams & Wilkins: 453–522.Google Scholar
  17. Brett, P. M., Zygogianni, P., Griffiths, G. S., Tomaz, M., Parkar, M., D’Aiuto, F. and Tonetti, M. (2005). “Functional gene polymorphisms in aggressive and chronic periodontitis.” J Dent Res 84(12): 1149–53.PubMedCrossRefGoogle Scholar
  18. Bretz, W. A., Weyant, R. J., Corby, P. M., Ren, D., Weissfeld, L., Kritchevsky, S. B., Harris, T., et al. (2005). “Systemic inflammatory markers, periodontal diseases, and periodontal infections in an elderly population.” J Am Geriatr Soc 53(9): 1532–37.PubMedCrossRefGoogle Scholar
  19. Brown, P., Brandel, J. P., Preece, M. and Sato, T. (2006). “Iatrogenic Creutzfeldt-Jakob disease: the waning of an era.” Neurology 67(3): 389–93.PubMedCrossRefGoogle Scholar
  20. Bruscoli, M. and Lovestone, S. (2004). “Is MCI really just early dementia? A systematic review of conversion studies.” Int Psychogeriatr 16(2): 129–40.PubMedCrossRefGoogle Scholar
  21. Brust, J. C. M. (2004). Ethanol. Neurological Aspects of Substance Abuse. J. C. M. Brust. Philadelphia, Elsevier Inc.: 317–425.Google Scholar
  22. Buchman, A. L. (1996). “Vitamin supplementation in the elderly: a critical evaluation.” Gastroenterologist 4(4): 262–75.PubMedGoogle Scholar
  23. Buchman, A. S., Schneider, J. A., Wilson, R. S., Bienias, J. L. and Bennett, D. A. (2006). “Body mass index in older persons is associated with Alzheimer disease pathology.” Neurology 67(11): 1949–54.PubMedCrossRefGoogle Scholar
  24. Buchman, A. S., Wilson, R. S., Bienias, J. L., Shah, R. C., Evans, D. A. and Bennett, D. A. (2005). “Change in body mass index and risk of incident Alzheimer disease.” Neurology 65(6): 892–97.PubMedCrossRefGoogle Scholar
  25. Bugalho, P. and Guimaraes, J. (2006). “Gait disturbance in normal pressure hydrocephalus: A clinical study.” Parkinsonism Relat Disord 13(7): 434–7.PubMedCrossRefGoogle Scholar
  26. Burn, D. J. (2006). “Cortical Lewy body disease and Parkinson’s disease dementia.” Curr Opin Neurol 19(6): 572–79.PubMedCrossRefGoogle Scholar
  27. Burt, B. (2005). “Position paper: epidemiology of periodontal diseases.” J Periodontol 76(8): 1406–19.PubMedCrossRefGoogle Scholar
  28. Cairns, N. J., Bigio, E. H., Mackenzie, I. R., Neumann, M., Lee, V. M., Hatanpaa, K. J., White, C. L. 3rd, Schneider, J. A., Grinberg, L. T., Halliday, G., Duyckaerts, C., Lowe, J. S., Holm, I. E., Tolnay, M., Okamoto, K., Yokoo, H., Murayama, S., Woulfe, J., Munoz, D. G., Dickson, D. W., Ince, P. G., Trojanowski J. Q., Mann, D. M.(2007) Consortium for Frontotemporal Lobar Degeneration. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol (Bed). 114(1): 5–22.CrossRefGoogle Scholar
  29. Chalmers, J. and Pearson, A. (2005). “Oral hygiene care for residents with dementia: a literature review.” J Adv Nurs 52(4): 410–19.PubMedCrossRefGoogle Scholar
  30. Chalmers, J. M., Carter, K. D. and Spencer, A. J. (2002). “Caries incidence and increments in community-living older adults with and without dementia.” Gerodontology 19(2): 80–94.PubMedCrossRefGoogle Scholar
  31. Chiappelli, F., Bauer, J., Spackman, S., Prolo, P., Edgerton, M., Armenian, C., Dickmeyer, J. and Harper, S. (2002). “Dental needs of the elderly in the 21st century.” Gen Dent 50(4): 358–63.PubMedGoogle Scholar
  32. Cronin-Stubbs, D., Beckett, L. A., Scherr, P. A., Field, T. S., Chown, M. J., Pilgrim, D. M., Bennett, D. A. and Evans, D. A. (1997). “Weight loss in people with Alzheimer’s disease: a prospective population based analysis.” Bmj 314(7075): 178–79.PubMedGoogle Scholar
  33. Cueto, A., Mesa, F., Bravo, M. and Ocana-Riola, R. (2005). “Periodontitis as risk factor for acute myocardial infarction. A case control study of Spanish adults.” J Periodontal Res 40(1): 36–42.PubMedCrossRefGoogle Scholar
  34. Cullen, P., Abid, F., Patel, A., Coope, B. and Ballard, C. G. (1997). “Eating disorders in dementia.” Int J Geriatr Psychiatry 12(5): 559–62.PubMedCrossRefGoogle Scholar
  35. Cummings, J. L. (2004). “Alzheimer’s disease.” N Engl J Med 351(1): 56–67.PubMedCrossRefGoogle Scholar
  36. Curran, T. and Lang, A. E. (1994). “Parkinsonian syndromes associated with hydrocephalus: case reports, a review of the literature, and pathophysiological hypotheses.” Mov Disord 9(5): 508–20.PubMedCrossRefGoogle Scholar
  37. D’Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P. M., Ready, D. and Tonetti, M. S. (2004). “Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers.” J Dent Res 83(2): 156–60.PubMedGoogle Scholar
  38. Desvarieux, M., Demmer, R. T., Rundek, T., Boden-Albala, B., Jacobs, D. R., Jr., Sacco, R. L. and Papapanou, P. N. (2005). “Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST).” Circulation 111(5): 576–82.PubMedCrossRefGoogle Scholar
  39. Doherty, S. A., Ross, A. and Bennett, C. R. (1994). “The oral hygiene performance test: development and validation of dental dexterity scale for the elderly.” Spec Care Dentist 14(4): 144–52.PubMedCrossRefGoogle Scholar
  40. Drachman, D. A. (2006). “Aging of the brain, entropy, and Alzheimer disease.” Neurology 67(8): 1340–52.PubMedCrossRefGoogle Scholar
  41. Duong, T., Nikolaeva, M. and Acton, P. J. (1997). “C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer’s disease.” Brain Res 749(1): 152–56.PubMedCrossRefGoogle Scholar
  42. Elias, M. F., Robbins, M. A., Budge, M. M., Elias, P. K., Brennan, S. L., Johnston, C., Nagy, Z. and Bates, C. J. (2006). “Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.” Psychosom Med 68(4): 547–54.PubMedCrossRefGoogle Scholar
  43. Engelhart, M. J., Geerlings, M. I., Meijer, J., Kiliaan, A., Ruitenberg, A., van Swieten, J. C., Stijnen, T., Hofman, A., Witteman, J. C. and Breteler, M. M. (2004). “Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study.” Arch Neurol 61(5): 668–72.PubMedCrossRefGoogle Scholar
  44. Evans, D. A., Smith, L. A., Scherr, P. A., Albert, M. S., Funkenstein, H. H. and Hebert, L. E. (1991). “Risk of death from Alzheimer’s disease in a community population of older persons.” Am J Epidemiol 134(4): 403–12.PubMedGoogle Scholar
  45. Fahn, S. (2005). Huntington Disease. Merritt’s neurology. L. P. Rowland. Philadelphia, Lippincott Williams & Wilkins: 803–807.Google Scholar
  46. Faxen-Irving, G., Basun, H. and Cederholm, T. (2005). “Nutritional and cognitive relationships and long-term mortality in patients with various dementia disorders.” Age Ageing 34(2): 136–41.PubMedCrossRefGoogle Scholar
  47. Frank, R. A., Galasko, D., Hampel, H., Hardy, J., de Leon, M. J., Mehta, P. D., Rogers, J., Siemers, E. and Trojanowski, J. Q. (2003). “Biological markers for therapeutic trials in Alzheimer’s disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer’s disease.” Neurobiol Aging 24(4): 521–36.PubMedCrossRefGoogle Scholar
  48. Franks, A. S. T. and Hedegard, B. (1973). Aging and Oral Health. Oxford, Blackwell Scientific.Google Scholar
  49. Friedlander, A. H. and Jarvik, L. F. (1987). “The dental management of the patient with dementia.” Oral Surg Oral Med Oral Pathol 64(5): 549–53.PubMedCrossRefGoogle Scholar
  50. Friedlander, A. H., Norman, D. C., Mahler, M. E., Norman, K. M. and Yagiela, J. A. (2006). “Alzheimer’s disease: psychopathology, medical management and dental implications.” J Am Dent Assoc 137(9): 1240–51.PubMedGoogle Scholar
  51. Galicia, J. C., Tai, H., Komatsu, Y., Shimada, Y., Ikezawa, I. and Yoshie, H. (2006). “Interleukin-6 receptor gene polymorphisms and periodontitis in a non-smoking Japanese population.” J Clin Periodontol 33(10): 704–709.PubMedCrossRefGoogle Scholar
  52. Gambassi, G., Landi, F., Lapane, K. L., Sgadari, A., Mor, V. and Bernabei, R. (1999). “Predictors of mortality in patients with Alzheimer’s disease living in nursing homes.” J Neurol Neurosurg Psychiatry 67(1): 59–65.PubMedGoogle Scholar
  53. Gatz, M., Mortimer, J. A., Fratiglioni, L., Johansson, B., Berg, S., Reynolds, C. A. and Pedersen, N. L. (2006). “Potentially modifiable risk factors for dementia in identical twins.” Alzheimer’s and Dementia: J Alzheimer’s Assoc 2(2): 110–117.Google Scholar
  54. Ghafouri, M., Amini, S., Khalili, K. and Sawaya, B. E. (2006). “HIV-1 associated dementia: symptoms and causes.” Retrovirology 3: 28.Google Scholar
  55. Gobel, S. (1984). “An electron microscopic analysis of the trans-synaptic effects of peripheral nerve injury subsequent to tooth pulp extirpations on neurons in laminae I and II of the medullary dorsal horn.” J Neurosci 4(9): 2281–90.PubMedGoogle Scholar
  56. Gobel, S. and Binck, J. M. (1977). “Degenerative changes in primary trigeminal axons and in neurons in nucleus caudalis following tooth pulp extirpations in the cat.” Brain Res 132(2): 347–54.PubMedCrossRefGoogle Scholar
  57. Green, R. and Kinsella, L. J. (1995). “Current concepts in the diagnosis of cobalamin deficiency.” Neurology 45(8): 1435–40.PubMedGoogle Scholar
  58. Greenwood, C. E., Tam, C., Chan, M., Young, K. W., Binns, M. A. and van Reekum, R. (2005). “Behavioral disturbances, not cognitive deterioration, are associated with altered food selection in seniors with Alzheimer’s disease.” J Gerontol A Biol Sci Med Sci 60(4): 499–505.PubMedGoogle Scholar
  59. Grove, M., Vonsattel, J. P., Mazzoni, P. and Marder, K. (2003). “Huntington’s disease.” Sci Aging Knowledge Environ 2003(43): dn3.Google Scholar
  60. Gurland, B. J., Wilder, D. E., Lantigua, R., Stern, Y., Chen, J., Killeffer, E. H. and Mayeux, R. (1999). “Rates of dementia in three ethnoracial groups.” Int J Geriatr Psychiatry 14(6): 481–93.PubMedCrossRefGoogle Scholar
  61. Harper, C. (2006). “Thiamine (vitamin B1) deficiency and associated brain damage is still common throughout the world and prevention is simple and safe!” Eur J Neurol 13(10): 1078–82.PubMedCrossRefGoogle Scholar
  62. Hebb, A. O. and Cusimano, M. D. (2001). “Idiopathic normal pressure hydrocephalus: a systematic review of diagnosis and outcome.” Neurosurgery 49(5): 1166–84; discussion 1184–86.PubMedCrossRefGoogle Scholar
  63. Hebert, L. E., Scherr, P. A., Beckett, L. A., Albert, M. S., Pilgrim, D. M., Chown, M. J., Funkenstein, H. H. and Evans, D. A. (1995). “Age-specific incidence of Alzheimer’s disease in a community population.” Jama 273(17): 1354–59.PubMedCrossRefGoogle Scholar
  64. Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A. and Evans, D. A. (2003). “Alzheimer disease in the US population: prevalence estimates using the 2000 census.” Arch Neurol 60(8): 1119–22.PubMedCrossRefGoogle Scholar
  65. Helmer, C., Joly, P., Letenneur, L., Commenges, D. and Dartigues, J. F. (2001). “Mortality with dementia: results from a French prospective community-based cohort.” Am J Epidemiol 154(7): 642–48.PubMedCrossRefGoogle Scholar
  66. Henry, R. G. and Wekstein, D. R. (1997). “Providing dental care for patients diagnosed with Alzheimer’s disease.” Dent Clin North Am 41(4): 915–43.PubMedGoogle Scholar
  67. Heyman, A., Peterson, B., Fillenbaum, G. and Pieper, C. (1996). “The consortium to establish a registry for Alzheimer’s disease (CERAD). Part XIV: Demographic and clinical predictors of survival in patients with Alzheimer’s disease.” Neurology 46(3): 656–60.PubMedGoogle Scholar
  68. Huey, E. D., Grafman, J., Wassermann, E. M., Pietrini, P., Tierney, M. C., Ghetti, B., Spina, S., et al. (2006). “Characteristics of frontotemporal dementia patients with a Progranulin mutation.” Ann Neurol 60(3): 374–80.PubMedCrossRefGoogle Scholar
  69. Hujoel, P. P., Drangsholt, M., Spiekerman, C. and DeRouen, T. A. (2000). “Periodontal disease and coronary heart disease risk.” Jama 284(11): 1406–10.PubMedCrossRefGoogle Scholar
  70. Hussein, S. B. (1989). “Use of a gum shield for Parkinson’s disease patients.” Br Dent J 166(9): 320.Google Scholar
  71. Hutton, B., Feine, J. and Morais, J. (2002). “Is there an association between edentulism and nutritional state?” J Can Dent Assoc 68(3): 182–87.PubMedGoogle Scholar
  72. Ikeda, M., Brown, J., Holland, A. J., Fukuhara, R. and Hodges, J. R. (2002). “Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer’s disease.” J Neurol Neurosurg Psychiatry 73(4): 371–76.PubMedCrossRefGoogle Scholar
  73. Iwamoto, N., Nishiyama, E., Ohwada, J. and Arai, H. (1994). “Demonstration of CRP immunoreactivity in brains of Alzheimer’s disease: immunohistochemical study using formic acid pretreatment of tissue sections.” Neurosci Lett 177(1–2): 23–26.PubMedCrossRefGoogle Scholar
  74. Jager, J., Gremeaux, T., Cormont, M., Le Marchand-Brustel, Y. and Tanti, J. F. (2007). “Interleukin-1{beta}-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.” Endocrinology 148(1): 241–51.PubMedCrossRefGoogle Scholar
  75. Janket, S. J., Baird, A. E., Chuang, S. K. and Jones, J. A. (2003). “Meta-analysis of periodontal disease and risk of coronary heart disease and stroke.” Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95(5): 559–69.PubMedGoogle Scholar
  76. Johnson, D. K., Wilkins, C. H. and Morris, J. C. (2006). “Accelerated weight loss may precede diagnosis in Alzheimer disease.” Arch Neurol 63(9): 1312–17.PubMedCrossRefGoogle Scholar
  77. Jolly, D. E., Paulson, R. B., Paulson, G. W. and Pike, J. A. (1989). “Parkinson’s disease: a review and recommendations for dental management.” Spec Care Dentist 9(3): 74–78.PubMedGoogle Scholar
  78. Joshipura, K. J., Hung, H. C., Rimm, E. B., Willett, W. C. and Ascherio, A. (2003). “Periodontal disease, tooth loss, and incidence of ischemic stroke.” Stroke 34(1): 47–52.PubMedCrossRefGoogle Scholar
  79. Kadiroglu, A. K., Kadiroglu, E. T., Sit, D., Dag, A. and Yilmaz, M. E. (2006). “Periodontitis is an important and occult source of inflammation in hemodialysis patients.” Blood Purif 24(4): 400–404.PubMedCrossRefGoogle Scholar
  80. Kaplan, D. (2000). Oral Health, Dental Care and Quality of Life Issues in Parkinson’s Disease. Parkinson’s Disease and Quality of Life. L. Cote, L. L. Sprinzeles, R. Elliott and A. H. Kutscher. Binghamton, NY, The Haworth Press: 87–92.Google Scholar
  81. Kato, T., Usami, T., Noda, Y., Hasegawa, M., Ueda, M. and Nabeshima, T. (1997). “The effect of the loss of molar teeth on spatial memory and acetylcholine release from the parietal cortex in aged rats.” Behav Brain Res 83(1–2): 239–42.PubMedCrossRefGoogle Scholar
  82. Keene, J. J., Jr., Galasko, G. T. and Land, M. F. (2003). “Antidepressant use in psychiatry and medicine: importance for dental practice.” J Am Dent Assoc 134(1): 71–79.PubMedGoogle Scholar
  83. Kennedy, M. A., Rosen, S., Paulson, G. W., Jolly, D. E. and Beck, F. M. (1994). “Relationship of oral microflora with oral health status in Parkinson’s disease.” Spec Care Dentist 14(4): 164–68.PubMedGoogle Scholar
  84. Kieser, J., Jones, G., Borlase, G. and MacFadyen, E. (1999). “Dental treatment of patients with neurodegenerative disease.” N Z Dent J 95(422): 130–34.PubMedGoogle Scholar
  85. Kocaelli, H., Yaltirik, M., Yargic, L. I. and Ozbas, H. (2002). “Alzheimer’s disease and dental management.” Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93(5): 521–24.PubMedGoogle Scholar
  86. Kondo, K., Niino, M. and Shido, K. (1994). “A case-control study of Alzheimer’s disease in Japan–significance of life-styles.” Dementia 5(6): 314–26.PubMedCrossRefGoogle Scholar
  87. Konsman, J. P. and Dantzer, R. (2001). “How the immune and nervous systems interact during disease-associated anorexia.” Nutrition 17(7–8): 664–68.PubMedCrossRefGoogle Scholar
  88. Kornman, K. S. (2006). “Interleukin 1 genetics, inflammatory mechanisms, and nutrigenetic opportunities to modulate diseases of aging.” Am J Clin Nutr 83(2): 475S–483S.PubMedGoogle Scholar
  89. Krall, E. A., Garvey, A. J. and Garcia, R. I. (1999). “Alveolar bone loss and tooth loss in male cigar and pipe smokers.” J Am Dent Assoc 130(1): 57–64.PubMedGoogle Scholar
  90. Lalla, E., Kaplan, S., Chang, S. M., Roth, G. A., Celenti, R., Hinckley, K., Greenberg, E. and Papapanou, P. N. (2006). “Periodontal infection profiles in type 1 diabetes.” J Clin Periodontol 33(12): 855–62.PubMedCrossRefGoogle Scholar
  91. Lalouschek, W., Schillinger, M., Hsieh, K., Endler, G., Greisenegger, S., Marculescu, R., Lang, W., Wagner, O., Cheng, S. and Mannhalter, C. (2006). “Polymorphisms of the inflammatory system and risk of ischemic cerebrovascular events.” Clin Chem Lab Med 44(8): 918–23.PubMedCrossRefGoogle Scholar
  92. Langston, J. W. (2006). “The Parkinson’s complex: parkinsonism is just the tip of the iceberg.” Ann Neurol 59(4): 591–96.PubMedCrossRefGoogle Scholar
  93. Lapeer, G. L. (1998). “Dementia’s impact on pain sensation: a serious clinical dilemma for dental geriatric care givers.” J Can Dent Assoc 64(3): 182–84, 187–92.PubMedGoogle Scholar
  94. Lippa, C. F. and Emre, M. (2006). “Characterizing clinical phenotypes: the Lewys in their life or the life of their Lewys?” Neurology 67(11): 1910–11.PubMedCrossRefGoogle Scholar
  95. Lorefat, B., Ganowiak, W., Wissing, U., Granerus, A. K. and Unosson, M. (2006). “Food habits and intake of nutrients in elderly patients with Parkinson’s disease.” Gerontology 52(3): 160–68.PubMedCrossRefGoogle Scholar
  96. Luchsinger, J. A., Reitz, C., Honig, L. S., Tang, M. X., Shea, S. and Mayeux, R. (2005). “Aggregation of vascular risk factors and risk of incident Alzheimer disease.” Neurology 65(4): 545–51.PubMedCrossRefGoogle Scholar
  97. Luchsinger, J. A., Tang, M. X., Miller, J., Green, R. and Mayeux, R. (2007). “Relation of higher folate intake to lower risk of Alzheimer disease in the elderly.” Arch Neurol 64(1): 86–92.PubMedCrossRefGoogle Scholar
  98. Machtei, E. E., Christersson, L. A., Grossi, S. G., Dunford, R., Zambon, J. J. and Genco, R. J. (1992). “Clinical criteria for the definition of “established periodontitis”.” J Periodontol 63(3): 206–14.PubMedGoogle Scholar
  99. Mayeux, R. (2003a). “Apolipoprotein E, Alzheimer disease, and African Americans.” Arch Neurol 60(2): 161–63.CrossRefGoogle Scholar
  100. Mayeux, R. (2003b). “Epidemiology of neurodegeneration.” Annu Rev Neurosci 26: 81–104.CrossRefGoogle Scholar
  101. McGeer, E. G., Yasojima, K., Schwab, C. and McGeer, P. L. (2001). “The pentraxins: possible role in Alzheimer’s disease and other innate inflammatory diseases.” Neurobiol Aging 22(6): 843–48.PubMedCrossRefGoogle Scholar
  102. McGeer, P. L. and McGeer, E. G. (2001). “Polymorphisms in inflammatory genes and the risk of Alzheimer disease.” Arch Neurol 58(11): 1790–92.PubMedCrossRefGoogle Scholar
  103. McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O’Brien, J. T., Feldman, H., Cummings, J., et al. (2005). “Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.” Neurology 65(12): 1863–72.PubMedCrossRefGoogle Scholar
  104. McKusick, V. A. (December 18, 2006). “Alzheimer Disease.” Online Mendelian Inheritance in Man, from Scholar
  105. Miller, A. J., Brunelle, J. A., Carlos, J. P., Brown, L. J. and Löe, H. (1987). Oral Health of United States Adults. Bethesda, MD, U.S. Department of Health & Human Services, Public Health Service, National Institutes of Health.Google Scholar
  106. Miyasaki, J. M., Shannon, K., Voon, V., Ravina, B., Kleiner-Fisman, G., Anderson, K., Shulman, L. M., Gronseth, G. and Weiner, W. J. (2006). “Practice Parameter: Evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology.” Neurology.Google Scholar
  107. Moore, A. R. and O’Keeffe, S. T. (1999). “Drug-induced cognitive impairment in the elderly.” Drugs Aging 15(1): 15–28.PubMedCrossRefGoogle Scholar
  108. Morris, C. H., Hope, R. A. and Fairburn, C. G. (1989). “Eating habits in dementia. A descriptive study.” Br J Psychiatry 154: 801–806.PubMedGoogle Scholar
  109. Mungas, D., Cooper, J. K., Weiler, P. G., Gietzen, D., Franzi, C. and Bernick, C. (1990). “Dietary preference for sweet foods in patients with dementia.” J Am Geriatr Soc 38(9): 999–1007.PubMedGoogle Scholar
  110. Murata, T., Miyazaki, H., Senpuku, H. and Hanada, N. (2001). “Periodontitis and serum interleukin-6 levels in the elderly.” Jpn J Infect Dis 54(2): 69–71.PubMedGoogle Scholar
  111. Neary, D., Snowden, J. and Mann, D. (2005). “Frontotemporal dementia.” Lancet Neurol 4(11): 771–80.PubMedCrossRefGoogle Scholar
  112. Nielsen, H., Lolk, A., Pedersen, I., Autzen, M., Sennef, C. and Kragh-Sorensen, P. (1991). “The accuracy of early diagnosis and predictors of death in Alzheimer’s disease and vascular dementia–a follow-up study.” Acta Psychiatr Scand 84(3): 277–82.PubMedCrossRefGoogle Scholar
  113. Niessen, L. C. and Jones, J. A. (1987). “Professional dental care for patients with dementia.” Gerodontology 6(2): 67–71.PubMedCrossRefGoogle Scholar
  114. Niessen, L. C., Jones, J. A., Zocchi, M. and Gurian, B. (1985). “Dental care for the patient with Alzheimer’s disease.” J Am Dent Assoc 110(2): 207–209.PubMedGoogle Scholar
  115. Nightingale, J. M., Walsh, N., Bullock, M. E. and Wicks, A. C. (1996). “Three simple methods of detecting malnutrition on medical wards.” J R Soc Med 89(3): 144–48.PubMedGoogle Scholar
  116. Nordenram, G. and Ljunggren, G. (2002). “Oral status, cognitive and functional capacity versus oral treatment need in nursing home residents: a comparison between assessments by dental and ward staff.” Oral Dis 8(6): 296–302.PubMedCrossRefGoogle Scholar
  117. Nordenram, G., Ryd-Kjellen, E., Ericsson, K. and Winblad, B. (1997). “Dental management of Alzheimer patients. A predictive test of dental cooperation in individualized treatment planning.” Acta Odontol Scand 55(3): 148–54.PubMedGoogle Scholar
  118. Nowjack-Raymer, R. E. and Sheiham, A. (2003). “Association of edentulism and diet and nutrition in US adults.” J Dent Res 82(2): 123–26.PubMedGoogle Scholar
  119. Ocasio, N. A., Solomowitz, B. H. and Sher, M. R. (2000). “Dental management of the patient with Alzheimer’s disease.” N Y State Dent J 66(3): 32–35.PubMedGoogle Scholar
  120. Offenbacher, S., Lin, D., Strauss, R., McKaig, R., Irving, J., Barros, S. P., Moss, K., Barrow, D. A., Hefti, A. and Beck, J. D. (2006). “Effects of Periodontal Therapy During Pregnancy on Periodontal Status, Biologic Parameters, and Pregnancy Outcomes: A Pilot Study.” J Periodontol 77(12): 2011–2024.PubMedCrossRefGoogle Scholar
  121. Ostuni, E. and Mohl, G. (1995). “Communicating more effectively with the confused or demented patient.” Gen Dent 43(3): 264–66.PubMedGoogle Scholar
  122. Papassotiropoulos, A., Bagli, M., Jessen, F., Bayer, T. A., Maier, W., Rao, M. L. and Heun, R. (1999). “A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer’s disease.” Ann Neurol 45(5): 666–68.PubMedCrossRefGoogle Scholar
  123. Petersen, P. E. (2003). “The World Oral Health Report 2003: continuous improvement of oral health in the 21st century–the approach of the WHO Global Oral Health Programme.” Community Dent Oral Epidemiol 31 Suppl 1: 3–23.CrossRefGoogle Scholar
  124. Petersen, P. E. and Yamamoto, T. (2005). “Improving the oral health of older people: the approach of the WHO Global Oral Health Programme.” Community Dent Oral Epidemiol 33: 81–92.PubMedCrossRefGoogle Scholar
  125. Pfeiffer, R. F. (2003). “Gastrointestinal dysfunction in Parkinson’s disease.” Lancet Neurol 2(2): 107–16.PubMedCrossRefGoogle Scholar
  126. Product-Information AMBIEN(R) Oral Tablet, zolpidem tartrate oral tablet. Sanofi-Synthelabo Inc, New York, NY, 2004.Google Scholar
  127. Product-Information Aricept package insert (Eisai—US). Rev Rec 4/1/99., 4/98.Google Scholar
  128. Product-Information Lunesta (TM), eszopiclone. Sepracor, Inc, Marlborough, MA, 2004.Google Scholar
  129. Product-Information Risperdal(R) risperidone. Janssen Pharmaceutica Products, L.P., Titusville, NJ, 2004.Google Scholar
  130. Product-Information ROZEREM(TM) oral tablets, ramelteon oral tablets. Takeda Pharmaceutical Company, Lincolnshire, IL, 2005.Google Scholar
  131. Product-Information Zyprexa(R), olanzapine. Eli Lilly & Company, Indianapolis, IN, 2003.Google Scholar
  132. Prusiner, S. B. (2001). “Shattuck lecture–neurodegenerative diseases and prions.” N Engl J Med 344(20): 1516–526.PubMedCrossRefGoogle Scholar
  133. Rainero, I., Bo, M., Ferrero, M., Valfre, W., Vaula, G. and Pinessi, L. (2004). “Association between the interleukin-1alpha gene and Alzheimer’s disease: a meta-analysis.” Neurobiol Aging 25(10): 1293–298.PubMedCrossRefGoogle Scholar
  134. Ransier, A., Epstein, J. B., Lunn, R. and Spinelli, J. (1995). “A combined analysis of a toothbrush, foam brush, and a chlorhexidine-soaked foam brush in maintaining oral hygiene.” Cancer Nurs 18(5): 393–96.PubMedCrossRefGoogle Scholar
  135. Rejnefelt, I., Andersson, P. and Renvert, S. (2006). “Oral health status in individuals with dementia living in special facilities.” Int J Dent Hyg 4(2): 67–71.PubMedCrossRefGoogle Scholar
  136. Ritchie, C. S., Joshipura, K., Silliman, R. A., Miller, B. and Douglas, C. W. (2000). “Oral health problems and significant weight loss among community-dwelling older adults.” J Gerontol A Biol Sci Med Sci 55(7): M366–M371.PubMedGoogle Scholar
  137. Roberts, F. A., McCaffery, K. A. and Michalek, S. M. (1997). “Profile of cytokine mRNA expression in chronic adult periodontitis.” J Dent Res 76(12): 1833–839.PubMedGoogle Scholar
  138. Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., et al.(2007). “The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.” Nat Genet. Feb;39(2): 168–77.CrossRefGoogle Scholar
  139. Sayer, R., Law, E., Connelly, P. J. and Breen, K. C. (2004). “Association of a salivary acetylcholinesterase with Alzheimer’s disease and response to cholinesterase inhibitors.” Clin Biochem 37(2): 98–104.PubMedCrossRefGoogle Scholar
  140. Scarmeas, N., Albert, M., Brandt, J., Blacker, D., Hadjigeorgiou, G., Papadimitriou, A., Dubois, B., et al. (2005a). “Motor signs predict poor outcomes in Alzheimer disease.” Neurology 64(10): 1696–703.CrossRefGoogle Scholar
  141. Scarmeas, N., Brandt, J., Albert, M., Hadjigeorgiou, G., Papadimitriou, A., Dubois, B., Sarazin, M., et al. (2005b). “Delusions and hallucinations are associated with worse outcome in Alzheimer disease.” Arch Neurol 62(10): 1601–608.Google Scholar
  142. Scarmeas, N., Brandt, J., Blacker, D., Albert, M., Hadjigeorgiou, G., Dubois, B., Devanand, D., Honig, L. and Stern, Y. (2007). “Disruptive behavior as predictor in Alzheimer’s disease.” Archives of Neurology [in press].Google Scholar
  143. Scarmeas, N., Hadjigeorgiou, G. M., Papadimitriou, A., Dubois, B., Sarazin, M., Brandt, J., Albert, M., et al. (2004). “Motor signs during the course of Alzheimer disease.” Neurology 63(6): 975–82.PubMedGoogle Scholar
  144. Scarmeas, N. and Honig, L. (2004). “Frontotemporal degenerative dementias.” Clin Neurosci Res 3(6): 449–60.CrossRefGoogle Scholar
  145. Scarmeas, N., Stern, Y., Mayeux, R. and Luchsinger, J. A. (2006a). “Mediterranean Diet, Alzheimer Disease, and Vascular Mediation.” Arch Neurol 63(12): 1709–17.Google Scholar
  146. Scarmeas, N., Stern, Y., Tang, M. X., Mayeux, R. and Luchsinger, J. A. (2006b). “Mediterranean diet and risk for Alzheimer’s disease.” Ann Neurol 59(6): 912–21.Google Scholar
  147. Schiffman, S. S., Graham, B. G., Suggs, M. S. and Sattely-Miller, E. A. (1998). “Effect of psychotropic drugs on taste responses in young and elderly persons.” Ann N Y Acad Sci 855: 732–37.PubMedCrossRefGoogle Scholar
  148. Schmidt, R., Schmidt, H., Curb, J. D., Masaki, K., White, L. R. and Launer, L. J. (2002). “Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study.” Ann Neurol 52(2): 168–74.PubMedCrossRefGoogle Scholar
  149. Schneider, L. S., Dagerman, K. and Insel, P. S. (2006a). “Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials.” Am J Geriatr Psychiatry 14(3): 191–210.Google Scholar
  150. Schneider, L. S., Tariot, P. N., Dagerman, K. S., Davis, S. M., Hsiao, J. K., Ismail, M. S., Lebowitz, B. D., et al. (2006b). “Effectiveness of atypical antipsychotic drugs in patients with Alzheimer’s disease.” N Engl J Med 355(15): 1525–38.CrossRefGoogle Scholar
  151. Seeley, W. W., Bauer, A. M., Miller, B. L., Gorno-Tempini, M. L., Kramer, J. H., Weiner, M. and Rosen, H. J. (2005). “The natural history of temporal variant frontotemporal dementia.” Neurology 64(8): 1384–90.PubMedGoogle Scholar
  152. Selnes, O. A. and Vinters, H. V. (2006). “Vascular cognitive impairment.” Nat Clin Pract Neurol 2(10): 538–47.PubMedCrossRefGoogle Scholar
  153. Services, U. S. D. o. H. a. H. (2000). Oral Health in America: A Report of the Surgeon General. D. o. H. a. H. Services. Rockville, MD, National Institutes of Health, National Institute of Dental and Craniofacial Research.Google Scholar
  154. Sevigny, J. J., Chin, S. S., Milewski, Y., Albers, M. W., Gordon, M. L. and Marder, K. (2005). “HIV encephalitis simulating Huntington’s disease.” Mov Disord 20(5): 610–13.PubMedCrossRefGoogle Scholar
  155. Shatenstein, B., Kergoat, M. J. and Nadon, S. (2001). “Anthropometric changes over 5 years in elderly Canadians by age, gender, and cognitive status.” J Gerontol A Biol Sci Med Sci 56(8): M483–M488.PubMedGoogle Scholar
  156. Sheiham, A. and Steele, J. (2001). “Does the condition of the mouth and teeth affect the ability to eat certain foods, nutrient and dietary intake and nutritional status amongst older people?” Public Health Nutr 4(3): 797–803.PubMedGoogle Scholar
  157. Sheng, J. G., Ito, K., Skinner, R. D., Mrak, R. E., Rovnaghi, C. R., Van Eldik, L. J. and Griffin, W. S. (1996). “In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis.” Neurobiol Aging 17(5): 761–66.PubMedCrossRefGoogle Scholar
  158. Ship, J. A. (1992). “Oral health of patients with Alzheimer’s disease.” J Am Dent Assoc 123(1): 53–58.PubMedGoogle Scholar
  159. Ship, J. A., DeCarli, C., Friedland, R. P. and Baum, B. J. (1990). “Diminished submandibular salivary flow in dementia of the Alzheimer type.” J Gerontol 45(2): M61–M66.PubMedGoogle Scholar
  160. Ship, J. A. and Puckett, S. A. (1994). “Longitudinal study on oral health in subjects with Alzheimer’s disease.” J Am Geriatr Soc 42(1): 57–63.PubMedGoogle Scholar
  161. Shlossman, M., Knowler, W. C., Pettitt, D. J. and Genco, R. J. (1990). “Type 2 diabetes mellitus and periodontal disease.” J Am Dent Assoc 121(4): 532–36.PubMedGoogle Scholar
  162. Shuman, S. K. and Bebeau, M. J. (1996). “Ethical issues in nursing home care: practice guidelines for difficult situations.” Spec Care Dentist 16(4): 170–76.PubMedGoogle Scholar
  163. Small, S. A. and Mayeux, R. (2005). Delirium and Dementia. Merritt’s neurology. L. P. Rowland. Philadelphia, Lippincott Williams & Wilkins: 3–8.Google Scholar
  164. Stein, P. S., Scheff, S. and Dawson, D. R. (2006). “Alzheimer Disease and Periodontal Disease: Mechanisms Underlying a Potential Bi-directional Relationship.” Grand Rounds Oral-Sys Med 1(3): 14–24.Google Scholar
  165. Strauss, S., Bauer, J., Ganter, U., Jonas, U., Berger, M. and Volk, B. (1992). “Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer’s disease patients.” Lab Invest 66(2): 223–30.PubMedGoogle Scholar
  166. Subsai, K., Kanoksri, S., Siwaporn, C., Helen, L., Kanokporn, O. and Wantana, P. (2006). “Neurological complications in AIDS patients receiving HAART: a 2-year retrospective study.” Eur J Neurol 13(3): 233–39.PubMedCrossRefGoogle Scholar
  167. Takeda, M., Ojima, M., Yoshioka, H., Inaba, H., Kogo, M., Shizukuishi, S., Nomura, M. and Amano, A. (2006). “Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients.” J Periodontol 77(1): 15–20.PubMedCrossRefGoogle Scholar
  168. Tang, M. X., Stern, Y., Marder, K., Bell, K., Gurland, B., Lantigua, R., Andrews, H., Feng, L., Tycko, B. and Mayeux, R. (1998). “The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics.” Jama 279(10): 751–55.PubMedCrossRefGoogle Scholar
  169. Thomson, W. M., Chalmers, J. M., Spencer, A. J. and Slade, G. D. (2000). “Medication and dry mouth: findings from a cohort study of older people.” J Public Health Dent 60(1): 12–20.PubMedCrossRefGoogle Scholar
  170. UN (2003). The United Nations Population Division. World Population Prospects: The 2002 Revision. New York, United Nations.Google Scholar
  171. Vas, C. J., Rajkumar, S., Tanyakitpisl, P. and Chandra, V. (2001). When Old Age Becomes a Disease, World Health Organization.Google Scholar
  172. Walls, A. W., Steele, J. G., Sheiham, A., Marcenes, W. and Moynihan, P. J. (2000). “Oral health and nutrition in older people.” J Public Health Dent 60(4): 304–307.PubMedCrossRefGoogle Scholar
  173. Wang, S. Y., Fukagawa, N., Hossain, M. and Ooi, W. L. (1997). “Longitudinal weight changes, length of survival, and energy requirements of long-term care residents with dementia.” J Am Geriatr Soc 45(10): 1189–195.PubMedGoogle Scholar
  174. Waring, S. C., Doody, R. S., Pavlik, V. N., Massman, P. J. and Chan, W. (2005). “Survival among patients with dementia from a large multi-ethnic population.” Alzheimer Dis Assoc Disord 19(4): 178–83.PubMedCrossRefGoogle Scholar
  175. Weaver, J. D., Huang, M. H., Albert, M., Harris, T., Rowe, J. W. and Seeman, T. E. (2002). “Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging.” Neurology 59(3): 371–78.PubMedGoogle Scholar
  176. White, H. (1998). “Weight change in Alzheimer’s disease.” J Nutr Health Aging 2(2): 110–112.PubMedGoogle Scholar
  177. White, H., Pieper, C. and Schmader, K. (1998). “The association of weight change in Alzheimer’s disease with severity of disease and mortality: a longitudinal analysis.” J Am Geriatr Soc 46(10): 1223–227.PubMedGoogle Scholar
  178. Wolf-Klein, G. P. and Silverstone, F. A. (1994). “Weight loss in Alzheimer’s disease: an international review of the literature.” Int Psychogeriatr 6(2): 135–42.PubMedCrossRefGoogle Scholar
  179. Wolfson, C., Wolfson, D. B., Asgharian, M., M’Lan, C. E., Ostbye, T., Rockwood, K. and Hogan, D. B. (2001). “A reevaluation of the duration of survival after the onset of dementia.” N Engl J Med 344(15): 1111–116.PubMedCrossRefGoogle Scholar
  180. Wood, J. A., Wood, P. L., Ryan, R., Graff-Radford, N. R., Pilapil, C., Robitaille, Y. and Quirion, R. (1993). “Cytokine indices in Alzheimer’s temporal cortex: no changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein.” Brain Res 629(2): 245–52.PubMedCrossRefGoogle Scholar
  181. Wu, T., Trevisan, M., Genco, R. J., Dorn, J. P., Falkner, K. L. and Sempos, C. T. (2000a). “Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow-up study.” Arch Intern Med 160(18): 2749–755.Google Scholar
  182. Wu, T., Trevisan, M., Genco, R. J., Falkner, K. L., Dorn, J. P. and Sempos, C. T. (2000b). “Exami-nation of the relation between periodontal health status and cardiovascular risk factors: serum total and high density lipoprotein cholesterol, C-reactive protein, and plasma fibrinogen.” Am J Epidemiol 151(3): 273–82.Google Scholar
  183. Yoneyama, T., Yoshida, M., Ohrui, T., Mukaiyama, H., Okamoto, H., Hoshiba, K., Ihara, S., et al. (2002). “Oral care reduces pneumonia in older patients in nursing homes.” J Am Geriatr Soc 50(3): 430–33.PubMedCrossRefGoogle Scholar
  184. Yurkstas, A. (1953). “The effect of masticatory exercise on the maximum force tolerance of individual teeth.” J Dent Res 32(3): 322–27.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • James M. Noble
    • 1
  • Nikolaos Scarmeas
  1. 1.Department of Neurology Columbia University Medical CenterNew York

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