Skip to main content

Lipophilic Microconstituents of Milk

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 606))

Abstract

Milk has long been recognized as a source of macro- and micronutrients, immunological components, and biologically active substances, which not only allow growth but also promote health in mammalian newborns. Many milk lipids, lipid-soluble substances, and their digested products are bioactive, including vitamins and vitamin-like substances. Vitamins A, E, D, and K and carotenoids are known as highly lipophilic food microconstituents (HLFMs), and all occur in milk. HLFMs also include phytosterols, which, although they are not vitamins, are nevertheless biologically active and present in milk. Fat-soluble micronutrients, including fat-soluble vitamins, are embedded in the milk fat fraction, and this has important implications for their bioaccessibility and bioavailability from milk. In fact, the fat component of milk is an effective delivery system for highly lipophilic microconstituents. The vitamin content of animal products can be enhanced by increasing the feed content of synthetic or natural vitamins or precursors. An advantage of augmenting milk microconstituents by animal nutrition rather than milk fortification is that it helps safeguard animal health, which is a primary factor in determining the quality, safety, and wholesomeness of animal-origin foods for human consumption. The milk fat delivery system offers numerous possibilities for exploitation by nutritionists. For example, the payload could consist of enhanced levels of several micronutrients, opening possibilities for synergic effects that are as yet incompletely understood.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allison, R. D., & Laven, R. A. (2001). Vitamin E for milk production in dairy cows: A review. Nutrition Abstracts and Reviews, Series B: Livestock Feeds and Feeding, 71, 43R–51R.

    Google Scholar 

  • Atwal, A. S., Hidiroglou, M., Kramer, J. K. G., & Binns, M. R. (1990). Effects of feeding α-tocopherol and calcium salts of fatty acids on vitamin E and fatty acid composition of cow's milk. Journal of Dairy Science, 73, 2832–2841.

    CAS  Google Scholar 

  • Azzi, A., Breyer, I., Feher, M., Pastori, M., Ricciarelli, R., Spycher, S., Staffieri, M., Stocker, A., Zimmer, S., & Zingg, J.-M. (2000). Specific cellular responses to α-tocopherol. Journal of Nutrition, 130, 1649–1652.

    CAS  Google Scholar 

  • Baldi, A. (2005). Vitamin E in dairy cows. Livestock Production Science, 98, 117–122.

    Article  Google Scholar 

  • Baldi, A., Bontempo, V., Cheli, F., Carli, S., Sgoifo Rossi, C., & Dell’Orto, V. (1997). Relative bioavailability of vitamin E in dairy cows following intraruminal administration of three different preparations of DL-α-tocopheryl acetate. Veterinary Research, 28, 512–524.

    Google Scholar 

  • Baldi, A., Savoini, G., Pinotti, L., Monfardini, E., Cheli, F., & Dell’Orto, V. (2000). Effects of vitamin E and different energy sources on vitamin E status, milk quality and reproduction in transition cows. Journal of Veterinary Medicine Series A, 47, 599–608.

    Article  CAS  Google Scholar 

  • Baldi, A., Losio, M. N., Cheli, F., Rebucci, R., Sangalli, L., Fusi, E., Bertasi, B., Pavoni, E., Carli, S., & Politis, I. (2004). Evaluation of the protective effects of α-tocopherol and retinol against ochratoxin A cytotoxicity. British Journal of Nutrition, 91, 507–512.

    Article  CAS  Google Scholar 

  • Baldi, A., Pinotti, L., & Fusi, E. (2006). Influence of antioxidants on ruminant health. Feed Compounder, 26, 19–25.

    Google Scholar 

  • Bauman, D. E., Lock, A. L., Corl, B. A., Ip, C., Salter, A. M., & Parodi, P. W. (2006). Milk fatty acids and human health: Potential role of conjugated linoleic acid and trans fatty acids. In K. Sejrsen, T. Hvelplund, & M. O. Nielsen (Eds.), Ruminant Physiology. Digestion, Metabolism and Impact of Nutrition on Gene Expression, Immunology and Stress (pp. 529–561). Wageningen, The Netherlands: Wageningen Academic Publishers.

    Google Scholar 

  • Beitz, D. C. (2005). Contributions of animal products to healthy diets. In Proceedings 2005 Cornell Nutrition Conference for Feed Manufacture (pp. 117–126). Ithaca, NY: Cornell University Press.

    Google Scholar 

  • Belitz, H. D., Grosch, W., & Schieberle, P. (2004). Vitamins. In M. M. Burghagen (Ed.),Food Chemistry (pp. 409–426). Berlin: Springer.

    Google Scholar 

  • Bell, J. A., Griinari, J. M., & Kennelly, J. J. (2006). Effect of safflower oil, flaxseed oil, monensin, and vitamin E on concentration of conjugated linoleic acid in bovine milk fat. Journal of Dairy Science, 89, 733–748.

    CAS  Google Scholar 

  • Blomhoff, R., & Blomhoff, H. K. (2006). Overview of retinoid metabolism and function. Journal of Neurobiology, 66, 606–630.

    Article  CAS  Google Scholar 

  • Blum, J. W., Hadorn, U., Sallmann, H. P., & Schuep, W. (1997). Delaying colostrum intake by one day impairs plasma lipid, essential fatty acid, carotene, retinol and α-tocopherol status in neonatal calves. Journal of Nutrition, 127, 2024–2029.

    CAS  Google Scholar 

  • Bontempo, V., Baldi, A., Cheli, F., Fantuz, F., Politis, I., Carli, S., & Dell'Orto, V. (2000). Kinetic behavior of three preparations of α-tocopherol after oral administration to postpubertal heifers. American Journal of Veterinary Research, 61, 589–593.

    Article  CAS  Google Scholar 

  • Borel, P. (2003). Factors affecting absorption of highly lipophilic food microconstituents (fat-soluble vitamins, carotenoids and phytosterols). Clinical Chemistry Laboratory Medicine, 41, 979–994.

    Article  CAS  Google Scholar 

  • Brewington, C. R., Caress, E. A., & Schwartz, D. (1970). Isolation and identification of new constituents in milk fat. Journal of Lipid Research, 11, 355–361.

    CAS  Google Scholar 

  • Brigelius-Flohé, R., Kelly, F. J., Salonen, J. T., Neuzil, J., Zingg, J. M., & Azzi, A. (2002). The European perspective on vitamin E: Current knowledge and future research. American Journal of Clinical Nutrition, 76, 703–716.

    Google Scholar 

  • Burton, G. W. (1994). Vitamin E: Molecular and biological function. Proceedings of the Nutrition Society, 53, 251–262.

    Article  CAS  Google Scholar 

  • Burton, G. W., Traber, M. G., Acuff, R. V., Walters, D. N., Kayden, H., Hughes, L., & Ingold, K. U. (1998). Human plasma and tissue α-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. American Journal of Clinical Nutrition, 67, 669–684.

    CAS  Google Scholar 

  • Calvo, M. S., Whiting, S. J., & Barton, C. N. (2004). Vitamin D fortification in the United States and Canada: Current status and data needs. American Journal of Clinical Nutrition, 80, 1710S–1716S.

    CAS  Google Scholar 

  • Charmley, E., & Nicholson, J. W. G. (1994). Influence of dietary fat source on oxidative stability and fatty acid composition of milk from cows receiving a low or high level of dietary vitamin E. Canadian Journal of Animal Science, 74, 657–664.

    CAS  Google Scholar 

  • Charmley, E., Nicholson, J. W. G., & Zee, J. A. (1993). Effect of supplemental vitamin E and selenium in the diet on vitamin E and selenium levels and control of oxidized flavor in milk from Holstein cows. Canadian Journal of Animal Science, 73, 453–457.

    Google Scholar 

  • Cheli, F., Politis, I., Rossi, L., Fusi, E., & Baldi, A. (2003). Effects of retinoids on proliferation and plasminogen activator expression in a bovine mammary epithelial cell line. Journal of Dairy Research, 70, 367–372.

    Article  CAS  Google Scholar 

  • Chew, B. P., & Park, J. S. (2004). Carotenoid action on immune system. Journal of Nutrition, 134, 257–261.

    Google Scholar 

  • Chilliard, Y., Ferlay, A., & Doreau, M. (2001). Effect of different types of forages, animal fat or marine oils in cow’s diet on milk secretion and composition, especially conjugated linoleic acid (CLA) and polyunsatured fatty acids. Livestock Production Science, 70, 31–48.

    Article  Google Scholar 

  • Clifton, P. M., Noakes, M., Sullivan, D., Erichsen, N., Ross, D., Annison, G., Fassoulakis, A., Cehun, M., & Nestel, P. (2004). Cholesterol-lowering effects of plant sterol esters differ in milk, yoghurt, bread and cereal. European Journal of Clinical Nutrition, 58, 503–509.

    Article  CAS  Google Scholar 

  • Debier, C., & Larondelle, Y. (2005). Vitamins A and E: Metabolism, roles and transfer to offspring. British Journal of Nutrition, 93, 153–174.

    Article  CAS  Google Scholar 

  • Debier, C., Pottier, J., Goffe, C., & Larondelle, Y. (2005). Present knowledge and unexpected behaviours of vitamins A and E in colostrum and milk. Livestock Production Science, 98, 135–147.

    Article  Google Scholar 

  • Durand, D., Scislowski, V., Chilliard, Y., Gruffat, D., & Bauchart, D. (2005). High fat rations and lipid peroxidation in ruminants; consequences on animal health and quality of products. In J. F. Hocquette & S. Gigli (Eds.), Indicators of Milk and Beef Quality (pp. 137–150). Wageningen, The Netherlands: Wageningen Academic Publishers.

    Google Scholar 

  • German, J. B., & Dillard, C. J. (2006). Composition, structure and absorption of milk lipids: A source of energy, fat-soluble nutrients and bioactive molecules. Critical Reviews in Food Science and Nutrition, 46, 57–92.

    Article  CAS  Google Scholar 

  • Goudjil, H., Torrado, S., Fontecha, J., Martínez-Castro, I., Fraga, J. M., & Juárez, M. (2003). Composition of cholesterol and its precursors in ovine milk. Lait, 83, 153–160.

    Article  CAS  Google Scholar 

  • Gulati, S. K., Cook, L. J., Ashes, J. R., & Scott, T. W. (1978). Effect of feeding protected cholesterol on ruminant milk fat secretion. Lipids, 13, 814–819.

    Article  CAS  Google Scholar 

  • Gurr, M. I. (1995). The nutritional significance of lipids. In P. F. Fox (Ed.), Lipids (pp. 349–402). London: Chapman & Hall.

    Google Scholar 

  • Havemose, M. S., Weisbjerg, M. R., Bredie, W. L. P., & Nielsen, J. H. (2004). Influence of feeding different types of roughage on the oxidative stability of milk. International Dairy Journal, 14, 563–570.

    Article  CAS  Google Scholar 

  • Havemose, M. S., Weisbjerg, M. R., Bredie, W. L. P., Poulsen, H. D., & Nielsen, J. H. (2006). Oxidative stability of milk influenced by fatty acids, antioxidants, and copper derived from feed. Journal of Dairy Science, 89, 1970–1980.

    CAS  Google Scholar 

  • Hayes, K. C., Pronczuk, A., & Perlman, D. (2001). Vitamin E in fortified cow milk uniquely enriches human plasma lipoproteins. American Journal of Clinical Nutrition, 74, 211–218.

    CAS  Google Scholar 

  • Hendy, G. N., Hruska, K. A., Mathew, S., & Goltzman, D. (2006). New insights into mineral and skeletal regulation by active forms of vitamin D. Kidney International, 69, 218–223.

    Article  CAS  Google Scholar 

  • Herrero, C., Granado, F., Blanco, I., & Olmedilla, B. (2002). Vitamin A and E content in dairy products: Their contribution to the recommended dietary allowances (RDA) for elderly people. Journal of Nutrition, Health & Aging, 6, 57–59.

    CAS  Google Scholar 

  • Herrero, C., Olmedilla, B., Granado, F., & Blanco, I. (2006). Bioavailability of vitamins A and E from whole and vitamin-fortified milks in control subjects. European Journal of Nutrition, 45, 391–398.

    Article  CAS  Google Scholar 

  • Hidiroglou, M. (1996). Pharmacokinetic profile of plasma tocopherol following intramuscular administration of acetylated alpha-tocopherol to sheep. Journal of Dairy Science, 79, 1027–1030.

    CAS  Google Scholar 

  • Hogan, J. S., Weiss, W. P., Todhunter, D. A., Smith, K. L., & Schoenberger, P. S. (1992). Bovine neutrophil responses to parenteral vitamin E. Journal of Dairy Science, 75, 340–399.

    Google Scholar 

  • Hogan, J. S., Weiss, W. P., & Smith, K. L. (1993). Role of vitamin E and selenium in host defence against mastitis. Journal of Dairy Science, 76, 2795–2908.

    CAS  Google Scholar 

  • HulShof, P. J. M., van Roekel-Jansen, T., van de Bovenkamp, P., & West, C. E. (2006). Variation in retinol and carotenoid content of milk and milk products in The Netherlands. Journal of Food Composition and Analysis, 19, 67–75.

    Article  CAS  Google Scholar 

  • Institute of Medicine (2001). Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press.

    Google Scholar 

  • International Dairy Federation (1992). Milk fat and milk fat products. Determination of cholesterol content. Brussels: IDF (FIL-IDF standard no. 159).

    Google Scholar 

  • Jensen, R. J. (1995). Fat-soluble vitamins in bovine milk. In R. G. Jensen (Ed.), Handbook of Milk Composition (pp. 718–726). San Diego: Academic Press.

    Google Scholar 

  • Jensen, S. K., & Nielsen, K. N. (1996). Tocopherols, retinol, β-carotene and fatty acids in fat globule membrane and fat globule core in cows' milk. Journal of Dairy Research, 63, 565–574.

    CAS  Google Scholar 

  • Jensen, S. K., Bjørnbak Johannsen, A. K., & Hermansen, J. E. (1999). Quantitative secretion and maximal secretion capacity of retinol, β-carotene and α-tocopherol into cow’s milk. Journal of Dairy Research, 66, 511–522.

    Article  CAS  Google Scholar 

  • Kaneki, M., Hosoi, T., Ouchi, Y., & Orimo, H. (2006). Pleiotropic actions of vitamin K: Protector of bone health and beyond? Nutrition, 22, 845–852.

    Article  CAS  Google Scholar 

  • Kaushik, S., Wander, R., Leonard, S., German, B., & Traber, M. G. (2001). Removal of fat from cow’s milk decreases the vitamin E contents of the resulting dairy products. Lipids, 36, 73–78.

    Article  CAS  Google Scholar 

  • Lamberg-Allardt, C. (2006). Vitamin D in foods and as supplements. Progress in Biophysics and Molecular Biology, 92, 33–38.

    Article  CAS  Google Scholar 

  • Lauridsen, C., Engel, H., Jensen, S. K., Craig, A. M., & Traber, M. G. (2002). Lactating sows and suckling piglets preferentially incorporate RRR- over all-raca-tocopherol into milk, plasma and tissue. Journal of Nutrition, 132, 1258–1264.

    CAS  Google Scholar 

  • Lindmark-Månsson, H., & Åkesson, B. (2000). Antioxidative factors in milk. British Journal of Nutrition, 84, S103–S110.

    Article  Google Scholar 

  • Macias, C., & Schweigert, F. J. (2001). Changes in the concentration of carotenoids, vitamin A, α-tocopherol and total lipids in human milk throughout early lactation. Annals of Nutrition & Metabolism, 45, 82–85.

    Article  CAS  Google Scholar 

  • Martinez, S., Barbs, C., & Herrera, E. (2002). Uptake of α-tocopherol by the mammary gland but not by white adipose tissue is dependent on lipoprotein lipase activity around parturition and during lactation in the rat. Metabolism, 51, 1444–1451.

    Article  CAS  Google Scholar 

  • McDowell, L. R. (1989). Vitamins in Animal Nutrition: Comparative Aspects to Human Nutrition, 1st ed. San Diego: Academic Press.

    Google Scholar 

  • McDowell, L. R. (2006). Vitamin nutrition of livestock animals: Overview from vitamin discovery to today. Canadian Journal of Animal Science, 86, 171–179.

    CAS  Google Scholar 

  • Meglia, G. E., Jensen, S. K., Lauridsen, C., & Persson, W. K. (2006). α-Tocopherol concentration and stereoisomer composition in plasma and milk from dairy cows fed natural or synthetic vitamin E around calving. Journal of Dairy Research, 73, 227–234.

    Article  CAS  Google Scholar 

  • Mensink, R. P., Ebbing, S., Lindhout, M., Plat, J., & van Heugten, M. M. (2002). Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. Atherosclerosis, 160, 205–213.

    Article  CAS  Google Scholar 

  • Meyer, E., Lamote, I., & Burvenich, C. (2005). Retinoids and steroids in bovine mammary gland immunobiology. Livestock Production Science, 98, 33–46.

    Article  Google Scholar 

  • Michel, J. J., Chew, B. P., Wong, T. S., Heirman, L. R., & Standaert, F. E. (1994). Modulatory effects of dietary β-carotene on blood and mammary leukocyte function in peripartum dairy cows. Journal of Dairy Science, 77, 1408–1422.

    Google Scholar 

  • Moreau, R. A., Whitaker, B. D., & Hicks, K. B. (2002). Phytosterols, phytostanols, and their conjugates in foods: Structural diversity, quantitative analysis, and health-promoting uses. Progress in Lipid Research, 41, 457–500.

    Article  CAS  Google Scholar 

  • Mulder, H., & Walstra, P. (1974). The Milk Fat Globule. Emulsion Science as Applied to Milk Products and Comparable Foods. Pudoc, Wageningen, and Commonwealth Agricultural Bureaux, Farnham Royal, The Netherlands.

    Google Scholar 

  • National Research Council (1989). Nutrient Requirements of Dairy Cattle,6th ed. Washington, DC: National Academy Press.

    Google Scholar 

  • National Research Council (2001). Nutrient Requirements in Dairy Cattle,7th ed. Washington, DC: National Academy Press.

    Google Scholar 

  • Nicholson, J. W. G., & St-Laurent, A. M. (1991). Effect of forage type and supplemental dietary vitamin E on milk oxidative stability. Canadian Journal of Animal Science, 71, 1181–1186.

    Google Scholar 

  • Noakes, M., Clifton, P. M., Doornbos, A. M. E., & Trautwein, E. A. (2005). Plant sterol ester-enriched milk and yoghurt effectively reduce serum cholesterol in modestly hypercholesterolemic subjects. European Journal of Nutrition, 44, 214–222.

    Article  CAS  Google Scholar 

  • Nozière, P., Graulet, B., Lucas, A., Martin, B., Grolier, P., & Doreau, M. (2006a). Carotenoids for ruminants: From forages to dairy products. Animal Feed Science and Technology, 131, 418–450.

    Article  CAS  Google Scholar 

  • Nozière, P., Grolier, P., Durand, D., Ferlay, A., Pradel, P., & Martin B. (2006b). Variations in carotenoids, fat-soluble micronutrients, and color in cows’ plasma and milk following changes in forage and feeding level. Journal of Dairy Science, 89, 2634–2648.

    Google Scholar 

  • Ortega, R. M., Palencia, A., & López-Sobaler, A. M. (2006). Improvement of cholesterol levels and reduction of cardiovascular risk via the consumption of phytosterols. British Journal of Nutrition, 96 (Suppl 1), S89–S93.

    CAS  Google Scholar 

  • Patton, S., Kelly, J. J., & Keenan, T. W. (1980). Carotene in bovine milk fat globules: Observations on origin and high content in tissue mitochondria. Lipids, 15, 33–38.

    Article  CAS  Google Scholar 

  • Politis, I., Hidiroglou, N., Batra, T. R., Gilmore, J. A., Gorewit, R. C., & Scherf, H. (1995). Effects of vitamin E on immune function of dairy cows. American Journal of Veterinary Research, 56, 179–184.

    CAS  Google Scholar 

  • Politis, I., Hidiroglou, N., Cheli, F., & Baldi A. (2001). Effects of vitamin E on urokinase-plasminogen activator receptor expression by bovine neutrophils. American Journal of Veterinary Research, 62, 1934–1938.

    Article  CAS  Google Scholar 

  • Rombaut, R., & Dewettinck, K. (2006). Properties, analysis and purification of milk polar lipids. International Dairy Journal, 16, 1362–1373.

    Article  CAS  Google Scholar 

  • Sahlin, A., & House, J. D. (2006). Enhancing the vitamin content of meat and eggs: Implications for the human diet. Canadian Journal of Animal Science, 86, 181–195.

    CAS  Google Scholar 

  • Sen, C. K., Khanna, S., & Roy, S. (2006). Tocotrienols: Vitamin E beyond tocopherols. Life Sciences, 78, 2088–2098.

    Article  CAS  Google Scholar 

  • Seymour, W. (2002). Vitamin nutrition of dairy cattle. In D. E. Pritchard (Ed.), North Carolina Dairy Nutrition Management Conference Proceedings(pp. 81–102). Raleigh: North Carolina State University.

    Google Scholar 

  • Smith, K. L., Harrison, J. H., Hancock, D. D., Todhunter, D. A., & Conrad, H. R. (1984). Effect of vitamin E and selenium supplementation on incidence of clinical mastitis and duration of clinical symptoms. Journal of Dairy Science, 67, 1293–1300.

    Article  CAS  Google Scholar 

  • Stahl, W., & Sies, H. (2005). Bioactivity and protective effects of natural carotenoids. Biochimica et Biophysica Acta, Molecular Basis of Disease, 1740, 101–107.

    Article  CAS  Google Scholar 

  • Stahl, W., Ale-Agha, N., & Polidori, M. C. (2002). Non-antioxidant properties of carotenoids. Journal of Biological Chemistry, 383, 553–558.

    Article  CAS  Google Scholar 

  • Tomlinson, J. E., Mitchell, G. E., Jr., Bradley, N. W., Tucker, R. E., Boling, J. A., & Schelling, G. T. (1974). Transfer of vitamin A from bovine liver to milk. Journal of Animal Science, 39, 813–817.

    Google Scholar 

  • Tylavsky, F. A., Cheng, S., Lyytikäinen, A., Viljakainen, H., & Lamberg-Allardt, C. (2006). Strategies to improve vitamin D status in Northern European children: Exploring the merits of vitamin D fortification and supplementation. Journal of Nutrition, 136, 1130–1134.

    CAS  Google Scholar 

  • Van Metre, D. C., & Callan, R. J. (2001). Selenium and vitamin E. The Veterinary Clinics of North America. Food Animal Practice, 7, 373–402.

    Google Scholar 

  • Volpe, R., Niittynen, L., Korpela, R., Sirtori, C., Bucci, A., Fraone, N., & Pazzucconi, F. (2001). Effects of yogurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia. British Journal of Nutrition, 86, 233–239.

    CAS  Google Scholar 

  • Walstra, P., & Jenness, R. (1984). Dairy Chemistry and Physics. New York: John Wiley & Sons.

    Google Scholar 

  • Weber, P. (2001). Vitamin K and bone health. Nutrition, 17, 880–887.

    Article  CAS  Google Scholar 

  • Weiss, W. P. (2005). Antioxidant nutrients, cow health, and milk quality. In 2005 Penn State Dairy Cattle Nutrition Workshop (pp. 11–18). Grantville, PA: Pennsylvania State University.

    Google Scholar 

  • Weiss, W. P., & Spears, J. W. (2006). Vitamin and trace mineral effects on immune function of ruminants. In K. Sejrsen, T. Hvelplund, & M. O. Nielsen (Eds.), Ruminant Physiology. Digestion, Metabolism and Impact of Nutrition on Gene Expression, Immunology and Stress (pp. 473–496). Wageningen, The Netherlands: Wageningen Academic Publishers.

    Google Scholar 

  • Weiss, W. P., & Wyatt, D. J. (2003). Effect of dietary fat and vitamin E on α-tocopherol in milk from dairy cows. Journal of Dairy Science, 86, 3582–3591.

    CAS  Google Scholar 

  • Wolpowitz, D., & Gilchrest, B. (2006). The vitamin D questions: How much do you need and how should you get it? Journal of the American Academy of Dermatology, 54, 301–317.

    Article  Google Scholar 

  • Zahar, M., & Smith, D. E. (1995). Vitamin A distribution among fat globule core, fat globule membrane, and serum fraction in milk. Journal of Dairy Science, 78, 498–505.

    Article  CAS  Google Scholar 

  • Zanker, I. A., Hammon, H. M., & Blum, J. W. (2000). Beta-carotene, retinol and alpha-tocopherol status in calves fed the first colostrum at 0–2, 6–7, 12–13 or 24–25 hours after birth. International Journal for Vitamin and Nutrition Research, 70, 305–310.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Baldi, A., Pinotti, L. (2008). Lipophilic Microconstituents of Milk. In: Bösze, Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology, vol 606. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74087-4_3

Download citation

Publish with us

Policies and ethics