On the Role of Breastfeeding in Health Promotion and the Prevention of Allergic Diseases

  • L. Rosetta
  • A. Baldi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 606)


Based on animal models, we specify the major role of different bioactive milk components known to participate significantly in neonatal health promotion and in protection against a large number of infectious diseases and the development of allergies and asthma.


Breast Milk Allergic Rhinitis Allergic Disease Human Milk Milk Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Aberg, N., Engstrom, I.,&Lindberg, U. (1989). Allergic diseases in Swedish school children. Acta Paediatrica Scandinavica, 78(2), 246–252.Google Scholar
  2. Almqvist, C., Pershagen, G.,&Wickman, M. (2005). Low socioeconomic status as a risk factor for asthma, rhinitis and sensitization at 4 years in a birth cohort. Clinical and Experimental Allergy, 355), 612–618.Google Scholar
  3. Arifeen, S., Black, R. E., Antelman, G., Baqui, A., Caulfield, L.,&Becker, S. (2001). Exclusive breastfeeding reduces acute respiratory infection and diarrhea deaths among infants in Dhaka slums. Pediatrics, 108(4), E67.CrossRefGoogle Scholar
  4. Arshad, S. H., Tariq, S. M., Matthews, S.,&Hakim, E. (2001). Sensitization to common allergens and its association with allergic disorders at age 4 years: A whole population birth cohort study. Pediatrics, 108(2), E33.CrossRefGoogle Scholar
  5. Baldi, A., Savoini, G., Cheli, F., Fantuz, F., Senatore, E., Bertocci, L.,&Politis, I. (1996). Changes in plasmin-plasminogen-plasminogen activator system in milk from Italian Fresian herds. International Dairy Journal, 6, 1045–1053.CrossRefGoogle Scholar
  6. Baldi, A., Politis, I., Pecorini, C., Fusi, E., Chronopoulou, R.,&Dell'Orto, V. (2005). Biological effects of milk proteins and their peptides with emphasis on those related to the gastrointestinal ecosystem. Journal of Dairy Research, 72 (Spec No.), 66–72.Google Scholar
  7. Balmer, S. E.,&Wharton, B. A. (1989). Diet and faecal flora in the newborn: Breast milk and infant formula. Archives of Disease in Childhood, 64, 1672.Google Scholar
  8. Batish, V. K., Chander, H., Zumdegeni, K. C., Bhatta, K. L.,&Singh, R. S. (1988). Antibacterial activity of lactoferrin against some common food-borne pathogenic organisms. Australian Journal of Dairy Technology, 5, 16–18.Google Scholar
  9. Baylis, J. M., Leeds, A. R.,&Challacombe, D. N. (1983). Persistent nausea and food aversions in pregnancy. A possible association with cow's milk allergy in infants. Clinical Allergy, 13(3), 263–269.CrossRefGoogle Scholar
  10. Becker, A. B. (2005). Primary prevention of allergy and asthma is possible. Clinical Reviews in Allergy and Immunology, 28(1), 5–16.CrossRefGoogle Scholar
  11. Bellamy, W., Takase, M., Yamauchi, K., Wakabayashi, H., Kawase, K.,&Tomita, M. (1992). Identification of the bactericidal domain of lactoferrin. Biochimica et Biophysica Acta, 1121, 130–136.Google Scholar
  12. Bottcher, M. F., Jenmalm, M. C.,&Bjorksten, B. (2003). Cytokine, chemokine and secretory IgA levels in human milk in relation to atopic disease and IgA production in infants. Pediatric Allergy and Immunology, 14(1), 35–41.CrossRefGoogle Scholar
  13. Bruno, G., Milita, O., Ferrara, M., Nisini, R., Cantani, A.,&Businco, L. (1993). Prevention of atopic diseases in high risk babies (long-term follow-up). Allergy Proceedings, 14(3), 181–186; discussion 186–187.CrossRefGoogle Scholar
  14. Burr, M. L., Limb, E. S., Maguire, M. J., Amarah, L., Eldridge, B. A., Layzell, J. C.,&Merrett, T. G. (1993). Infant feeding, wheezing, and allergy: A prospective study. Archives of Disease in Childhood, 68(6), 724–728.Google Scholar
  15. Businco, L., Marchetti, F., Pellegrini, G., Cantani, A.,&Perlini, R. (1983). Prevention of atopic disease in "at-risk newborns" by prolonged breast-feeding. Annals of Allergy, 51 (2 Pt 2), 296–299.Google Scholar
  16. Butland, B. K., Strachan, D. P., Lewis, S., Bynner, J., Butler, N.,&Britton, J. (1997). Investigation into the increase in hay fever and eczema at age 16 observed between the 1958 and 1970 British birth cohorts. British Medical Journal, 315(7110), 717–721.Google Scholar
  17. Chan-Yeung, M., Manfreda, J., Dimich-Ward, H., Ferguson, A., Watson, W.,&Becker, A. (2000). A randomized controlled study on the effectiveness of a multifaceted intervention program in the primary prevention of asthma in high-risk infants. Archives of Pediatrics&Adolescent Medicine, 154(7), 657–663.Google Scholar
  18. Chandra, R. K. (1997). Five-year follow-up of high-risk infants with family history of allergy who were exclusively breast-fed or fed partial whey hydrolysate, soy, and conventional cow's milk formulas. Journal of Pediatric Gastroenterology and Nutrition, 24(4), 380–388.CrossRefGoogle Scholar
  19. Chandra, R. K. (2000). Food allergy and nutrition in early life: Implications for later health. Proceedings of the Nutrition Society, 59(2), 273–277.Google Scholar
  20. Chandra, R. K., Singh, G.,&Shridhara, B. (1989). Effect of feeding whey hydrolysate, soy and conventional cow milk formulas on incidence of atopic disease in high risk infants. Annals of Allergy, 63(2), 102–106.Google Scholar
  21. Chien, P. F.,&Howie, P. W. (2001). Breast milk and the risk of opportunistic infection in infancy in industrialised and non-industrialised settings. Advances in Nutritional Research, 10, 69–104.Google Scholar
  22. Chulada, P. C., Arbes, S. J., Jr., Dunson, D.,&Zeldin, D. C. (2003). Breast-feeding and the prevalence of asthma and wheeze in children: Analyses from the Third National Health and Nutrition Examination Survey, 1988–1994. Journal of Allergy and Clinical Immunology, 111(2), 328–336.CrossRefGoogle Scholar
  23. Clare, D. A.,&Swaisgood, H. E. (2000). Bioactive milk peptides: A prospectus. Journal of Dairy Science, 83, 1187–1195.Google Scholar
  24. Cogswell, J. J., Mitchell, E. B.,&Alexander, J. (1987). Parental smoking, breast feeding, and respiratory infection in development of allergic diseases. Archives of Disease in Childhood, 62(4), 338–344.Google Scholar
  25. Dionysius, D. A., Grieve, P. A.,&Milne, J. M. (1993). Forms of lactoferrin: Their antibacterial effect on enterotoxigenic Escherichia coli. Journal of Dairy Science, 76, 2597–2606.Google Scholar
  26. Douglass, J. A.,&O'Hehir, R. E. (2006). Diagnosis, treatment and prevention of allergic disease: The basics. The Medical Journal of Australia, 185(4), 228–233.Google Scholar
  27. Duchen, K., Casas, R., Fageras-Bottcher, M., Yu, G.,&Bjorksten, B. (2000). Human milk polyunsaturated long-chain fatty acids and secretory immunoglobulin A antibodies and early childhood allergy. Pediatric Allergy and Immunology, 11(1), 29–39.CrossRefGoogle Scholar
  28. Epton, M. J., Town, G. I., Ingham, T., Wickens, K., Fishwick, D., Crane, J.,&NZA2CS (2007). The New Zealand Asthma and Allergy Cohort Study (NZA2CS): Assembly, demographics and investigations. BMC Public Health, 7, 26.CrossRefGoogle Scholar
  29. Exner, H.,&Greinecker, G. (1996). [Prevention of allergy.] Wiener medizinishe Wochenschrift 1946, 146(15), 406–411.Google Scholar
  30. Fantuz, F., Polidori, F., Cheli, F.,&Baldi, A. (2001). Plasminogen activation system in goat milk and its relation with composition and coagulation properties. Journal of Dairy Science, 84, 1786–1790.Google Scholar
  31. Field, C. J. (2005). The immunological components of human milk and their effect on immune development in infants. Journal of Nutrition, 135, 1–4.Google Scholar
  32. Fiocchi, A., Borella, E., Di Donna, C., Lista, G. L., Turrini, D.,&Riva, E. (1984). [Respiratory atopy and season of birth: Epidemiologic considerations.] La Pediatria Medica e Chirurgica, 6(5), 673–676.Google Scholar
  33. Forsyth, B. W., McCarthy, P. L.,&Leventhal, J. M. (1985). Problems of early infancy, formula changes, and mothers' beliefs about their infants. Journal of Pediatrics, 106(6), 1012–1017.CrossRefGoogle Scholar
  34. Golding, J., Emmett, P. M.,&Rogers, I. S. (1997). Does breast feeding have any impact on non-infectious, non-allergic disorders? Early Human Development, 49 (Suppl), S131–142.Google Scholar
  35. Gruskay, F. L. (1982). Comparison of breast, cow, and soy feedings in the prevention of onset of allergic disease: A 15-year prospective study. Clinical Pediatrics, 21(8), 486–491.CrossRefGoogle Scholar
  36. Habbick, B. F., Pizzichini, M. M., Taylor, B., Rennie, D., Senthilselvan, A.,&Sears, M. R. (1999). Prevalence of asthma, rhinitis and eczema among children in 2 Canadian cities: The International Study of Asthma and Allergies in Childhood. Canadian Medical Association Journal, 160(13), 1824–1828.Google Scholar
  37. Halken, S. (2003). Early sensitisation and development of allergic airway disease—Risk factors and predictors. Paediatric Respiratory Reviews, 4(2), 128–134.CrossRefGoogle Scholar
  38. Halken, S. (2004). Prevention of allergic disease in childhood: Clinical and epidemiological aspects of primary and secondary allergy prevention. Pediatric Allergy and Immunology, 15 (Suppl 16), 4–5, 9–32.Google Scholar
  39. Haque, M. F., Hussain, M., Sarkar, A., Hoque, M. M., Ara, F. A.,&Sultana, S. (2002). Breast-feeding counselling and its effect on the prevalence of exclusive breast-feeding. Journal of Health, Population, and Nutrition, 20(4), 312–316.Google Scholar
  40. Harris, J. M., Cullinan, P., Williams, H. C., Mills, P., Moffat, S., White, C.,&Newman Taylor, A. J. (2001). Environmental associations with eczema in early life. British Journal of Dermatology, 144(4), 795–802.CrossRefGoogle Scholar
  41. Hill, H. S., Doull, F., Rutherford, K. J.,&Cross, M. L. (2000). Immunoregulatory peptides in bovine milk. British Journal of Nutrition, 84 (Suppl 1), S111–S117.Google Scholar
  42. Hoek, K. S., Milne, J. M., Grieve, P. A., Dionysius, D. A.,&Smith, R. (1997). Antibacterial activity of bovine lactoferrin-derived peptides. Antimicrobial Agents and Chemotherapy, 41, 54–59.Google Scholar
  43. Hoppu, U., Kalliomaki, M., Laiho, K.,&Isolauri, E. (2001). Breast milk—Immunomodulatory signals against allergic diseases. Allergy, 56 (Suppl 67), 23–26.Google Scholar
  44. Isaacs, C. E. (2005). Human milk inactivates pathogens individually, additively and synergistically. Journal of Nutrition, 135(135), 1286–1288.Google Scholar
  45. Isaacs, C. E., Kashyap, S., Heird, W. C.,&Thormar, H. (1990). Antiviral and antibacterial lipids in human milk and infant formula feeds. Archives of Disease in Childhood, 65, 861–864.Google Scholar
  46. Kannan, S., Carruth, B. R.,&Skinner, J. (1999). Infant feeding practices of Anglo American and Asian Indian American mothers. Journal of the American College of Nutrition, 18(3), 279–286.Google Scholar
  47. Kemp, A.,&Kakakios, A. (2004). Asthma prevention: Breast is best? Journal of Paediatrics and Child Health, 40(7), 337–339.CrossRefGoogle Scholar
  48. Kim, W. S., Ohashi, M., Tanaka, T., Kumura, H., Kim, G. Y., Kwon, I. K., Goh, J. S.,&Shimazaki, K. (2004). Growth-promoting effects of lactoferrin on L. acidophilus and Bifidobacterium spp. Biometals, 17, 279–283.Google Scholar
  49. Kjellman, N. I.,&Nilsson, L. (1999). Is allergy prevention realistic and beneficial? Pediatric Allergy and Immunology, 10(12 Suppl), 11–17.Google Scholar
  50. Kramer, M. S. (1988). Does breast feeding help protect against atopic disease? Biology, methodology, and a golden jubilee of controversy. Journal of Pediatrics, 112(2), 181–190.CrossRefGoogle Scholar
  51. Kull, I., Wickman, M., Lilja, G., Nordvall, S. L.,&Pershagen, G. (2002). Breast feeding and allergic diseases in infants—A prospective birth cohort study. Archives of Disease in Childhood, 87(6), 478–481.CrossRefGoogle Scholar
  52. Kummeling, I., Thijs, C., Penders, J., Snijders, B. E., Stelma, F., Reimerink, J., Koopmans, M., Dagnelie, P. C., Huber, M., Jansen, M. C., de Bie, R.,&van den Brandt, P. A. (2005). Etiology of atopy in infancy: The KOALA Birth Cohort Study. Pediatric Allergy and Immunology, 16(8), 679–684.CrossRefGoogle Scholar
  53. Kummeling, I., Stelma, F. F., Dagnelie, P. C., Snijders, B. E., Penders, J., Huber, M., van Ree, R., van den Brandt, P. A.,&Thijs, C. (2007). Early life exposure to antibiotics and the subsequent development of eczema, wheeze, and allergic sensitization in the first 2 years of life: The KOALA Birth Cohort Study. Pediatrics, 119(1), e225–e231.CrossRefGoogle Scholar
  54. Kurukulaaratchy, R. J., Matthews, S.,&Arshad, S. H. (2006). Relationship between childhood atopy and wheeze: What mediates wheezing in atopic phenotypes? Annals of Allergy, Asthma and Immunology, 97(1), 84–91.CrossRefGoogle Scholar
  55. Li, E. W.,&Mine, Y. (2004). Immunoenhancing effects of bovine glycomacropeptide and its derivatives on the proliferative response and phagocytic activity of human macrophage-like cells, U937. Journal of Agricultural Food Chemistry, 52, 2704–2708.CrossRefGoogle Scholar
  56. Liepke, C., Adermann, K., Raida, M., Mägert, H. J., Forssmann, W. G.,&Zucht, H. D. (2002). Human milk provides peptides highly stimulating the growth of bifidobacteria. European Journal of Biochemistry, 269, 712–718.CrossRefGoogle Scholar
  57. Lönnerdal, B. (2000). Breast milk: A truly functional food. Nutrition, 16, 509–511.CrossRefGoogle Scholar
  58. Lönnerdal, B. (2003). Nutritional and physiologic significance of human milk proteins. American Journal of Clinical Nutrition, 77, 1537S–1543S.Google Scholar
  59. Marks, G. B., Mihrshahi, S., Kemp, A. S., Tovey, E. R., Webb, K., Almqvist, C., Ampon, R. D., Crisafulli, D., Belousova, E. G., Mellis, C. M., Peat, J. K.,&Leeder, S. R. (2006). Prevention of asthma during the first 5 years of life: A randomized controlled trial. Journal of Allergy and Clinical Immunology, 118(1), 53–61.CrossRefGoogle Scholar
  60. Martinez, F. D. (2007). Gene-environment interactions in asthma: With apologies to William of Ockham. Proceedings of the American Thoracic Society, 4(1), 26–31.CrossRefGoogle Scholar
  61. McGeady, S. J. (2004). Immunocompetence and allergy. Pediatrics, 113(4 Suppl), 1107–1113.Google Scholar
  62. Meisel, H. (1997). Biochemical properties of bioactive peptides derived from milk proteins: Potential nutraceuticals for food and pharmaceutical applications. Livestock Production Science, 50, 125–138.CrossRefGoogle Scholar
  63. Nafstad, P., Nystad, W.,&Jaakkola, J. J. (2002). The use of a feather quilt, childhood asthma and allergic rhinitis: A prospective cohort study. Clinical and Experimental Allergy, 32(8), 1150–1154.CrossRefGoogle Scholar
  64. Newburg, D. S. (1996). Oligosaccharides and glycoconjugates in human milk: Their role in host defence. Journal of Mammary Gland Biology and Neoplasia, 1, 271–283.CrossRefGoogle Scholar
  65. Newburg, D. S. (2005). Innate immunity and human milk. Journal of Nutrition, 135, 1308–1312.Google Scholar
  66. Oddy, W. H., Sherriff, J. L., de Klerk, N. H., Kendall, G. E., Sly, P. D., Beilin, L. J., Blake, K. B., Landau, L. I.,&Stanley, F. J. (2004). The relation of breastfeeding and body mass index to asthma and atopy in children: A prospective cohort study to age 6 years. American Journal of Public Health, 94(9), 1531–1537.CrossRefGoogle Scholar
  67. Oram, J. D.,&Reiter, B. (1968). Inhibition of bacteria by lactoferrin and other iron-chelating agents. Biochimica et Biophysica Acta, 170, 351–365.Google Scholar
  68. Payne, K., Davidson, P. M.,&Oliver, S. P. (1990). Influence of bovine lactoferrin on the growth of Listeria monocytogenes. Journal of Food Protection, 53, 468–472.Google Scholar
  69. Pecorini, C., Martino, P., Reggi, S., Fogher, C.,&Baldi, A. (2003). Evaluation of biological effects of recombinant porcine lactoferrin expressed in Pichia pastoris yeast. Proceedings of the 6th International Conference on Lactoferrin: Structure, Function and Applications, Capri, Italy p70.Google Scholar
  70. Pecorini, C., Savazzini, F., Martino, P. A., Fusi, E., Fogher, C.,&Baldi, A. (2005). Heterologous expression of biologically active porcine lactoferrin in Pichia pastoris yeast. Veterinary Research Communications, 29 (Suppl 2), 379–382.Google Scholar
  71. Pecquet, S., Bovetto, L., Maynard, F.,&Fritsche, R. (2000). Peptides obtained by tryptic hydrolysis of bovine β-lactoglobulin induce specific oral tolerance in mice. Journal of Allergy and Clinical Immunology, 105, 514–521.CrossRefGoogle Scholar
  72. Penders, J., Thijs, C., van den Brandt, P. A., Kummeling, I., Snijders, B., Stelma, F., Adams, H., van Ree, R.,&Stobberingh, E. E. (2007). Gut microbiota composition and development of atopic manifestations in infancy: The KOALA birth cohort study. Gut 56 (5), 661–667.Google Scholar
  73. Politis, I. (1996). Plasminogen activator system: Implications for mammary cell growth and involution. Journal of Dairy Science, 79, 1097–1107.Google Scholar
  74. Politis, I., Voudouri, A., Bizelis, I.,&Zervas, G. (2003). The effect of various vitamin E derivatives on the urokinase-plasminogen activator system of ovine macrophages and neutrophils. British Journal of Nutrition, 89, 259–265.CrossRefGoogle Scholar
  75. Prescott, S. L. (2003). Early origins of allergic disease: A review of processes and influences during early immune development. Current Opinion in Allergy and Clinical Immunology, 3(2), 125–132.CrossRefGoogle Scholar
  76. Prescott, S. L.,&Tang, M. L. (2005). The Australasian Society of Clinical Immunology and Allergy position statement: Summary of allergy prevention in children. Medical Journal of Australia, 182(9), 464–467.Google Scholar
  77. Prioult, G., Pecquet, S.,&Fliss, I. (2004). Stimulation of interleukin-10 production by acidic β-lactoglobulin-derived peptides hydrolyzed with Lactobacillus paracasei NCC2461 peptidases. Clinical and Diagnostic Laboratory Immunology, 11, 266–271.CrossRefGoogle Scholar
  78. Radon, K.,&Schulze, A. (2006). Adult obesity, farm childhood, and their effect on allergic sensitization. Journal of Allergy and Clinical Immunology, 118(6), 1279–1283.CrossRefGoogle Scholar
  79. Reilly, J. J.,&Wells, J. C. (2005). Duration of exclusive breast-feeding: Introduction of complementary feeding may be necessary before 6 months of age. British Journal of Nutrition, 94(6), 869–872.CrossRefGoogle Scholar
  80. Rigotti, E., Piacentini, G. L., Ress, M., Pigozzi, R., Boner, A. L.,&Peroni, D. G. (2006). Transforming growth factor-beta and interleukin-10 in breast milk and development of atopic diseases in infants. Clinical and Experimental Allergy, 36(5), 614–618.CrossRefGoogle Scholar
  81. Sausenthaler, S., Koletzko, S., Schaaf, B., Lehmann, I., Borte, M., Herbarth, O., von Berg, A., Wichmann, H. E., Heinrich, J., the LISA Study Group (2007). Maternal diet during pregnancy in relation to eczema and allergic sensitization in the offspring at 2 y of age. American Journal of Clinical Nutrition, 85(2), 530–537.Google Scholar
  82. Schanbacher, F. L., Talhouk, R. S.,&Murray, F. A. (1997). Biology and origin of bioactive peptides in milk. Livestock Production Science, 50, 105–123.CrossRefGoogle Scholar
  83. Schanbacher, F. L., Talhouk, R. S., Murray, F. A., Gherman, L. I.,&Willett, L. B. (1998). Milk-borne bioactive peptides. International Dairy Journal, 8, 393–403.CrossRefGoogle Scholar
  84. Sears, M. R., Greene, J. M., Willan, A. R., Taylor, D. R., Flannery, E. M., Cowan, J. O., Herbison, G. P.,&Poulton, R. (2002). Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: A longitudinal study. Lancet, 360(9337), 901–907.CrossRefGoogle Scholar
  85. Snijders, B. E., Damoiseaux, J. G., Penders, J., Kummeling, I., Stelma, F. F., van Ree, R., van den Brandt, P. A.,&Thijs, C. (2006). Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study). Clinical and Experimental Allergy, 36(12), 1609–1615.CrossRefGoogle Scholar
  86. Snijders, B. E., Thijs, C., Kummeling, I., Penders, J.,&van den Brandt, P. A. (2007). Breastfeeding and infant eczema in the first year of life in the KOALA birth cohort study: A risk period-specific analysis. Pediatrics, 119(1), e137–e141.CrossRefGoogle Scholar
  87. Stoney, R. M., Woods, R. K., Hosking, C. S., Hill, D. J., Abramson, M. J.,&Thien, F. C. (2004). Maternal breast milk long-chain n-3 fatty acids are associated with increased risk of atopy in breastfed infants. Clinical and Experimental Allergy, 34(2), 194–200.CrossRefGoogle Scholar
  88. Sugiyama, M., Arakawa, H., Ozawa, K., Mizuno, T., Mochizuki, H., Tokuyama, K.,&Morikawa, A. (2007). Early-life risk factors for occurrence of atopic dermatitis during the first year. Pediatrics, 119(3), e716–e723.CrossRefGoogle Scholar
  89. Sunyer, J., Torrent, M., Muñoz-Ortiz, L., Ribas-Fitó, N., Carrizo, D., Grimalt, J., Antó, J. M.,&Cullinan, P. (2005). Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children. Environmental Health Perspectives, 113(12), 1787–1790.CrossRefGoogle Scholar
  90. Sunyer, J., Jarvis, D., Gotschi, T., Garcia-Esteban, R., Jacquemin, B., Aguilera, I., Ackerman, U., de Marco, R., Forsberg, B., Gislason, T., Heinrich, J., Norbäck, D., Villani, S.,&Künzli, N. (2006a). Chronic bronchitis and urban air pollution in an international study. Occupational and Environmental Medicine, 63(12), 836–843.Google Scholar
  91. Sunyer, J., Torrent, M., Garcia-Esteban, R., Ribas-Fitó, N., Carrizo, D., Romieu, I., Antó, J. M.,&Grimalt, J. O. (2006b). Early exposure to dichlorodiphenyldichloroethylene, breastfeeding and asthma at age six. Clinical and Experimental Allergy, 36(10), 1236–1241.CrossRefGoogle Scholar
  92. Sutas, Y., Soppi, E., Korhonen, H., Syvaoja, E. L., Saxelin, M., Rokka, T.,&Isolauri, E. (1996). Suppression of lymphocyte proliferation in in vitro bovine casein hydrolyzed with Lactobacillus casei GG-derived enzymes. Journal of Allergy and Clinical Immunology, 98, 216–224.CrossRefGoogle Scholar
  93. Telemo, E.,&Hanson, L. A. (1996). Antibodies in milk. Journal of Mammary Gland Biology and Neoplasia, 1, 243–249.CrossRefGoogle Scholar
  94. Teraguchi, S., Shin, K., Ozawa, K., Nakamura, S., Fukuwatari, Y., Tsuyuri, S., Namihira, H.,&Shimanura, S. (1995). Bacteriostatic effect of orally administered bovine lactoferrin on proliferation of Clostridium species in the gut of mice fed bovine milk. Applied and Environmental Microbiology, 61, 501–506.Google Scholar
  95. Thestrup-Pedersen, K. (2003). Atopic eczema. What has caused the epidemic in industrialised countries and can early intervention modify the natural history of atopic eczema? Journal of Cosmetic Dermatology, 2(3–4), 202–210.CrossRefGoogle Scholar
  96. Van der Kraan, M. I. A., Groenink, J., Nazmi, K., Veerman, E. C. I., Bolscher, J. G. M.,&Amerongen, A. V. N. (2004). Lactoferrampin: A novel antimicrobial peptide in the N1-domain of bovine lactoferrin. Peptides, 25, 177–183.CrossRefGoogle Scholar
  97. Van Leeuwen, P., Oosting, S. J., Mouwen, J.,&Verstegen, M. W. A. (2000). Effects of a lactoperoxidase system and lactoferrin, added to a milk replacer diet, on severity of diarrhoea, intestinal morphology and microbiology of digesta and faeces in young calves. Journal of Animal Physiology and Animal Nutrition, 83, 15–23.CrossRefGoogle Scholar
  98. van Odijk, J., Kull, I., Borres, M. P., Brandtzaeg, P., Edberg, U., Hanson, L. A., Host, A., Kuitunen, M., Olsen, S. F., Skerfving, S., Sundell, J.,&Wille, S. (2003). Breastfeeding and allergic disease: A multidisciplinary review of the literature (1966–2001) on the mode of early feeding in infancy and its impact on later atopic manifestations. Allergy, 58(9), 833–843.CrossRefGoogle Scholar
  99. Wilson, A. C., Forsyth, J. S., Greene, S. A., Irvine, L., Hau, C.,&Howie, P. W. (1998). Relation of infant diet to childhood health: Seven year follow up of cohort of children in Dundee infant feeding study. British Medical Journal, 316(7124), 21–25.Google Scholar
  100. Wilson, W. H. (1983). Recurrent acute otitis media in infants—Role of immune complexes acquired in utero. Laryngoscope, 93(4), 418–421.Google Scholar
  101. Wjst, M., Dharmage, S., André, E., Norback, D., Raherison, C., Villani, S., Manfreda, J., Sunyer, J., Jarvis, D., Burney, P.,&Svanes, C. (2005). Latitude, birth date, and allergy. PLoS Medicine, 2(10), e294.CrossRefGoogle Scholar
  102. Woodcock, A., Lowe, L. A., Murray, C. S., Simpson, B. M., Pipis, S. D., Kissen, P., Simpson, A., Custovic, A.,&NMAaAS Group (2004). Early life environmental control: Effect on symptoms, sensitization, and lung function at age 3 years. American Journal of Respiratory and Critical Care Medicine, 170(4), 433–439.Google Scholar
  103. Zacharasiewicz, A., Zidek, T., Haidinger, G., Waldhor, T., Suess, G.,&Vutuc, C. (1999). Indoor factors and their association to respiratory symptoms suggestive of asthma in Austrian children aged 6–9 years. Wien Klin Wochenschr, 111(21), 882–886.Google Scholar
  104. Zieger, R. S., Heller, S., Mellon, M. H., Forsythe, A. B., O'Connor, R. D., Hamburger, R. N.&Schatz, M. (1989). Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy a randomized study. Journal of Allergy and Clinical Immunology, 84(1), 72–89.Google Scholar

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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • L. Rosetta
    • 1
  • A. Baldi
  1. 1.CNRS UPR 2147Amidal MouchezFrance

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