The Cholesterol Cutoff

  • Robert M. Kaplan


Total Cholesterol Heart Attack High Cholesterol Blood Cholesterol National Cholesterol Education Program 
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  1. 1.
    Keys AB. Coronary heart disease in seven countries. New York: American Heart Association; 1970.Google Scholar
  2. 2.
    Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. May 12 1998;97(18):1837–1847.Google Scholar
  3. 3.
    Stamler J, Daviglus ML, Garside DB, Dyer AR, Greenland P, Neaton JD. Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity. JAMA. Jul 19 2000;284(3):311–318.CrossRefGoogle Scholar
  4. 4.
    The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA. Jan 20 1984;251(3):365–374.CrossRefGoogle Scholar
  5. 5.
    The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA. Jan 20 1984;251(3):351–364.CrossRefGoogle Scholar
  6. 6.
    MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. Jul 6 2002;360(9326):7–22.Google Scholar
  7. 7.
    Multiple risk factor intervention trial: risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group. JAMA. Sep 24 1982;248(12):1465–1477.CrossRefGoogle Scholar
  8. 8.
    Kaplan RM. Two pathways to prevention. Am Psychol. 2000;55(4):382–396.CrossRefGoogle Scholar
  9. 9.
    Walsh JM, Pignone M. Drug treatment of hyperlipidemia in women. JAMA. May 12 2004;291(18):2243–2252.CrossRefGoogle Scholar
  10. 10.
    Kaplan RM. Behavioral epidemiology, health promotion, and health services. Med Care. May 1985;23(5):564–583.CrossRefGoogle Scholar
  11. 11.
    Muldoon MF, Manuck SB, Matthews KA. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. Brit Phycol J. Aug 11 1990;301(6747):309–314.Google Scholar
  12. 12.
    Golomb BA. Cholesterol and violence: is there a connection? Ann Intern Med. 1998;128(6):478–487.Google Scholar
  13. 13.
    Caro J, Klittich W, McGuire A, et al. The West of Scotland coronary prevention study: economic benefit analysis of primary prevention with pravastatin [see comments]. Brit Phycol J (Clinical Research Ed.). 1997;315(7122):1577–1582.Google Scholar
  14. 14.
    Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA. 1998;279(20):1615–1622.CrossRefGoogle Scholar
  15. 15.
    Packard CJ, Ford I, Robertson M, et al. Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Circulation. Nov 15 2005;112(20):3058–3065.CrossRefGoogle Scholar
  16. 16.
    Criqui MH, Golomb BA. Low and lowered cholesterol and total mortality. J Am Coll Cardiol. Sep 1 2004;44(5):1009–1010.CrossRefGoogle Scholar
  17. 17.
    Sempos CT, Cleeman JI, Carroll MD, et al. Prevalence of high blood cholesterol among US adults: an update based on guidelines from the second report of the National Cholesterol Education Program Adult Treatment Panel. JAMA. 1993;269(23):3009–3014.CrossRefGoogle Scholar
  18. 18.
    Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. May 16 2001;285(19):2486–2497.Google Scholar
  19. 19.
    Collins R, Armitage J, Parish S, Sleigh P, Peto R. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet. Jun 14 2003;361(9374):2005–2016.CrossRefGoogle Scholar
  20. 20.
    Gurm HS, Hoogwerf B. The Heart Protection Study: high-risk patients benefit from statins, regardless of LDL-C level. Cleve Clin J Med. Nov 2003;70(11):991–997.CrossRefGoogle Scholar
  21. 21.
    Choudhry NK, Stelfox HT, Detsky AS. Relationships between authors of clinical practice guidelines and the pharmaceutical industry. JAMA. 2002;287(5):612–617.CrossRefGoogle Scholar
  22. 22.
    Kaplan RM, Ong M. Rationale and Public Health Implications of Changing CHD Risk Factor Definitions. Annu Rev Public Health. 2007;28:312–344.Google Scholar
  23. 23.
    Shepherd J, Blauw GJ, Murphy MB, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet. Nov 23 2002;360(9346):1623–1630.CrossRefGoogle Scholar
  24. 24.
    Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). JAMA. Dec 18 2002;288(23):2998–3007.Google Scholar
  25. 25.
    Sever PS, Dahlof B, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial – Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet. Apr 5 2003;361(9364):1149–1158.CrossRefGoogle Scholar
  26. 26.
    Cannon CP, McCabe CH, Belder R, Breen J, Braunwald E. Design of the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT)-TIMI 22 trial. Am J Cardiol. Apr 1 2002;89(7):860–861.CrossRefGoogle Scholar
  27. 27.
    Khaleghi M, Kaplan RM. Effects of Changing Illness Thresholds on Healthcare Costs and Health Outcomes. Unpublished paper, University of California, San Diego, 2007.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Robert M. Kaplan
    • 1
  1. 1.UCLA School of Public HealthLos AngelesUSA

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