Estrogen Receptors in Resistance to Hormone Therapy

  • Matthew H. Herynk
  • Suzanne A. W. Fuqua
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 608)


Estrogen and its receptors α and β (ERα and ERβ) play a major role in tumor progression and approximately two-thirds of breast cancers express these functional receptors. Thus, the ER is a major target for current and developing therapies. Although most ER-positive tumors initially respond to hormonal therapies such as tamoxifen, many tumors will eventually become resistant to tamoxifen induced growth inhibition. This chapter will discuss molecular mechanisms that contribute to hormonal resistance of current therapies including ERα mutations, the roles of proliferation and apoptosis in tumor homeostasis and receptor coregulator proteins. Additionally, the role of nonclassical ERα signaling through growth factor receptors and the subsequent downstream-initiated signaling, and the role of the progesterone receptors will be discussed.


Breast Cancer Estrogen Receptor Progesterone Receptor Hormone Resistance Tamoxifen Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  1. 1.Breast CenterBaylor College of MedicineHoustonUSA

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