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Management of Severe Dengue in Children

  • Christopher Moxon
  • Bridget Wills
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 609)

Although recognised for over two centuries, during the last 50 years dengue has emerged as an important burden on global health, with significant increases in the number of cases reported from many sites in the tropics together with the spread of major disease epidemics across Asia and South America.

Keywords

Disseminate Intravascular Coagulation Dengue Virus Fluid Resuscitation Dengue Fever Dengue Haemorrhagic Fever 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alderson P, Schierhout G, Roberts I, and Bunn F. (2000). Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev, (2):CD000567.Google Scholar
  2. Bethell DB, Flobbe K, and Cao XT, et al. (1998). Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. J Infect Dis, 177(3):778–782.PubMedCrossRefGoogle Scholar
  3. Bethell DB, Gamble J, and Pham PL, et al. (2001). Noninvasive measurement of microvascular leakage in patients with dengue hemorrhagic fever. Clin Infect Dis, 32(2):243–253.PubMedCrossRefGoogle Scholar
  4. Bhamarapravati N. (1997). Pathology of infection. In Gubler DJ and Kuno G (eds.), Dengue and Dengue Hemorrhagic Fever. CAB International, Wallingford, pp. 115–132.Google Scholar
  5. Bokisch VA, Top FH, Jr., Russell PK, Dixon FJ, and Muller-Eberhard HJ. (1973). The potential pathogenic role of complement in dengue hemorrhagic shock syndrome. N Engl J Med, 289(19):996–1000.PubMedGoogle Scholar
  6. Chiu YC, Wu KL, and Kuo CH, et al. (2005). Endoscopic findings and management of dengue patients with upper gastrointestinal bleeding. Am J Trop Med Hyg, 73(2):441–444.PubMedGoogle Scholar
  7. Chuansumrit A, Tangnararatchakit K, and Lektakul Y, et al. (2004). The use of recombinant activated factor VII for controlling life-threatening bleeding in dengue shock syndrome. Blood Coagul Fibrinolysis, 15(4):335–342.PubMedCrossRefGoogle Scholar
  8. Chuansumrit A, Wangruangsatid S, Lektrakul Y, Chua MN, Zeta Capeding MR, and Bech OM. (2005). Control of bleeding in children with dengue hemorrhagic fever using recombinant activated factor VII: a randomized, double-blind, placebo-controlled study. Blood Coagul Fibrinolysis, 16(8):549–555.PubMedCrossRefGoogle Scholar
  9. Chungue E, Poli L, Roche C, Gestas P, Glaziou P, and Markoff LJ. (1994). Correlation between detection of plasminogen cross-reactive antibodies and hemorrhage in dengue virus infection. J Infect Dis, 170(5):1304–1307.PubMedGoogle Scholar
  10. Deen JL, Harris E, and Wills B, et al. (2006). The WHO dengue classification and case definitions: time for a reassessment. Lancet, 368(9530):170–173.PubMedCrossRefGoogle Scholar
  11. Dung NM, Day NP, and Tam DT, et al. (1999). Fluid replacement in dengue shock syndrome: a randomized, double-blind comparison of four intravenous-fluid regimens. Clin Infect Dis, 29(4):787–794.PubMedCrossRefGoogle Scholar
  12. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, and Norton R. (2004). A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med, 350(22):2247–2256.PubMedCrossRefGoogle Scholar
  13. Gamble J, Gartside IB, and Christ F. (1993). A reassessment of mercury in silastic strain gauge plethysmography for microvascular permeability assessment in man. J Physiol, 464:407–422.PubMedGoogle Scholar
  14. Green S, Vaughn DW, and Kalayanarooj S, et al. (1999). Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. J Infect Dis, 179(4):755–762.PubMedCrossRefGoogle Scholar
  15. Griffel MI and Kaufman BS. (1992). Pharmacology of colloids and crystalloids. Crit Care Clin, 8(2):235–253.PubMedGoogle Scholar
  16. Gubler DJ. (1998). Dengue and dengue hemorrhagic fever. Clin Microbiol Rev, 11(3):480–496.PubMedGoogle Scholar
  17. Halstead SB and O’Rourke EJ. (1977). Antibody-enhanced dengue virus infection in primate leukocytes. Nature, 265(5596):739–741.PubMedCrossRefGoogle Scholar
  18. Halstead SB, Nimmannitya S, and Cohen SN. (1970). Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. Yale J Biol Med, 42(5):311–328.PubMedGoogle Scholar
  19. Harris E, Videa E, and Perez L, et al. (2000). Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua. Am J Trop Med Hyg, 63(1–2):5–11.PubMedGoogle Scholar
  20. Haupt MT, Kaufman BS, and Carlson RW. (1992). Fluid resuscitation in patients with increased vascular permeability. Crit Care Clin, 8(2):341–353.PubMedGoogle Scholar
  21. Leitmeyer KC, Vaughn DW, and Watts DM, et al. (1999). Dengue virus structural differences that correlate with pathogenesis. J Virol, 73(6):4738–4747.PubMedGoogle Scholar
  22. Markoff LJ, Innis BL, Houghten R, and Henchal LS. (1991). Development of cross-reactive antibodies to plasminogen during the immune response to dengue virus infection. J Infect Dis, 164(2):294–301.PubMedGoogle Scholar
  23. Michel CC and Curry FE. (1999). Microvascular permeability. Physiol Rev, 79(3):703–761.PubMedGoogle Scholar
  24. Mongkolsapaya J, Dejnirattisai W, and Xu XN, et al. (2003). Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat Med, 9(7):921–927.PubMedCrossRefGoogle Scholar
  25. Ngo NT, Cao XT, and Kneen R, et al. (2001). Acute management of dengue shock syndrome: a randomized double-blind comparison of 4 intravenous fluid regimens in the first hour. Clin Infect Dis, 32(2):204–213.PubMedCrossRefGoogle Scholar
  26. Pea L, Roda L, and Moll F. (2001). Desmopressin treatment for a case of dengue hemorrhagic fever/dengue shock syndrome. Clin Infect Dis, 33(9):1611–1612.PubMedCrossRefGoogle Scholar
  27. Petchclai B and Saelim P. (1978). Circulating immune complexes in dengue haemorrhagic fever. Lancet, 2(8090):638–639.PubMedCrossRefGoogle Scholar
  28. Phuong CX, Nhan NT, and Kneen R, et al. (2004). Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: is the world health organization classification system helpful? Am J Trop Med Hyg, 70(2):172–179.PubMedGoogle Scholar
  29. Rico-Hesse R, Harrison LM, and Salas RA, et al. (1997). Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology, 230(2):244–251.PubMedCrossRefGoogle Scholar
  30. Rigau-Perez JG and Bonilla GL. (1999). An evaluation of modified case definitions for the detection of dengue hemorrhagic fever. Puerto Rico Association of Epidemiologists. P R Health Sci J, 18(4):347–352.PubMedGoogle Scholar
  31. Rosen L, Drouet MT, and Deubel V. (1999). Detection of dengue virus RNA by reverse transcription-polymerase chain reaction in the liver and lymphoid organs but not in the brain in fatal human infection. Am J Trop Med Hyg, 61(5):720–724.PubMedGoogle Scholar
  32. Schierhout G and Roberts I. (1998). Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials. BMJ, 316(7136):961–964.PubMedGoogle Scholar
  33. Srichaikul T and Nimmannitya S. (2000). Haematology in dengue and dengue haemorrhagic fever. Baillieres Best Pract Res Clin Haematol, 13(2):261–276.PubMedCrossRefGoogle Scholar
  34. Sumarmo, Talogo W, Asrin A, Isnuhandojo B, and Sahudi A. (1982). Failure of hydrocortisone to affect outcome in dengue shock syndrome. Pediatrics, 69(1):45–49.PubMedGoogle Scholar
  35. Tassniyom S, Vasanawathana S, Chirawatkul A, and Rojanasuphot S. (1993). Failure of high-dose methylprednisolone in established dengue shock syndrome: a placebo-controlled, double-blind study. Pediatrics, 92(1):111–115.PubMedGoogle Scholar
  36. Tassniyom S, Vasanawathana S, Dhiensiri T, Nisalak A, and Chirawatkul A. (1997). Failure of carbazochrome sodium sulfonate (AC-17) to prevent dengue vascular permeability or shock: a randomized, controlled trial. J Pediatr, 131(4):525–528.PubMedCrossRefGoogle Scholar
  37. Tsai CJ, Kuo CH, Chen PC, and Changcheng CS. (1991). Upper gastrointestinal bleeding in dengue fever. Am J Gastroenterol, 86(1):33–35.PubMedGoogle Scholar
  38. Wang W, Chao D, and Kao CL, et al. (2003). High levels of plasma dengue viral load during defervescence in patients with dengue hemorrhagic fever: implications for pathogenesis. Virology, 305(2):330–338.PubMedCrossRefGoogle Scholar
  39. Webb AR. (2000). The appropriate role of colloids in managing fluid imbalance: a critical review of recent meta-analytic findings. Crit Care, 4(Suppl 2):S26–S32. Epub 2000 Oct 13.PubMedGoogle Scholar
  40. WHO. (1997). Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. World Health Organisation, Geneva.Google Scholar
  41. Wills BA, Oragui EE, and Stephens AC, et al. (2002). Coagulation abnormalities in dengue hemorrhagic fever: serial investigations in 167 Vietnamese children with Dengue shock syndrome. Clin Infect Dis, 35(3):277–285.PubMedCrossRefGoogle Scholar
  42. Wills BA, Oragui EE, and Dung NM, et al. (2004). Size and charge characteristics of the protein leak in dengue shock syndrome. J Infect Dis, 190(4):810–818.PubMedCrossRefGoogle Scholar
  43. Wills BA, Nguyen MD, and Ha TL, et al. (2005). Comparison of three fluid solutions for resuscitation in dengue shock syndrome. N Engl J Med, 353(9):877–889.PubMedCrossRefGoogle Scholar
  44. Wu SJ, Grouard-Vogel G, and Sun W, et al. (2000). Human skin Langerhans cells are targets of dengue virus infection. Nat Med, 6(7):816–820.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Christopher Moxon
  • Bridget Wills
    • 1
  1. 1.Senior Clinical Research FellowOxford University Clinical Research Unit, Hospital for Tropical DiseasesHo Chi Minh CityVietnam

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