Urinary Lipocalins in Rodenta:is there a Generic Model?
It is increasingly clear that mediation of chemical signals is not the exclusive domain of low molecular volatile or water soluble metabolites. Pheromone binding proteins play an important role in mediating the activity of low molecular weight compounds, while proteins and peptides can also act as information molecules in their own right. Understanding of the role played by proteins in scents has been derived largely from the study of Major Urinary Proteins (MUPs) in the mouse (Mus musculus domesticus) and the rat (Rattus norvegicus). As part of an ongoing programme to explore the diversity and complexity of urinary proteins in rodents, we have applied a proteomics-based approach to the analysis of urinary proteins from a wider range of rodents. These data suggest that many species express proteins in their urine that are structurally similar to the MUPs, although there is considerable diversity in concentration, in sexual dimorphism and in polymorphic complexity. This is likely to reflect a high degree of species-specificity in communication and the information that these proteins provide in scent signals.
KeywordsUrinary Protein Bank Vole House Mouse Scent Mark Djungarian Hamster
Unable to display preview. Download preview PDF.
- Cheetham, S. A., Thom, M. D., Jury, F., Ollier, W. E. R., Beynon, R. J. and Hurst, J. L. (2007) MUPs, not MHC provide a specific signal for individual recognision in wild house mice. (unpublished manuscript).Google Scholar
- Darwish Marie, A., Veggerby, C., Robertson, D. H., Gaskell, S. J., Hubbard, S. J., Martinsen, L., Hurst, J. L. and Beynon, R. J. (2001) Effect of polymorphisms on ligand binding by mouse major urinary proteins. Protein Sci. 10, 411–7.Google Scholar
- Hurst, J. L., Beynon, R. J., Humphries, R. E., Malone, N., Nevison, C. M., Payne, C. E., Robertson, D. H. L. and Veggerby, C. (2001). Information in scent signals of competitive social status: the interface between behaviour and chemistry. In: A. Marchelewska-Koj, D. Muller-Schwarze and J. Lepri (Eds.), Chemical Signals in Vertebrates 9, Plenum Press, New York, pp. 43–50.Google Scholar
- Lai, S. C. and Johnston, R. E. (1994) Individual Odors in Djungarian Hamsters (Phodopus campbelli). Ethology 96, 117–126.Google Scholar
- Lehman-McKeeman, L. D., Caudill, D., Rodriguez, P. A. and Eddy, C. (1998) 2-sec-butyl-4,5-dihydrothiazole is a ligand for mouse urinary protein and rat alpha 2u-globulin: physiological and toxicological relevance. Toxicol. Appl. Pharmacol. 149, 32–40.Google Scholar
- Mucignat Caretta, C., Caretta, A. and Cavaggioni, A. (1995) Pheromonally accelerated puberty is enhanced by previous experience of the same stimulus. Physiol. Behav. 57, 901–3.Google Scholar
- Natochin Iu, V., Meshcherskii, I. G., Goncharevskaia, O. A., Makarenko, I. G., Shakhmatova, E. I., Ugriumov, M. V., Feoktistova, N. and Alonso, G. (1994) [A comparative study of the osmoregulating system in the hamsters Phodopus roborovskii and Phodopus sungorus]. Zh. Evol. Biokhim. Fiziol. 30, 344–57.PubMedGoogle Scholar
- Payne, C. E., Malone, N., Humphries, R. E., Bradbrook, C., Veggerby, C., Beynon, R. J. and Hurst, J. L. (2001). Heterogeneity of major urinary proteins in house mice: population and sex differences. In: A. Marchelewska-Koj, D. Muller-Schwarze and J. Lepri (Eds.), Chemical Signals in Vertebrates 9, Plenum Press, New York, pp. 233–240.Google Scholar
- Robertson, D. H., Hurst, J. L., Searle, J. B., Gunduz, I. and Beynon, R. J. (2007) Characterization and comparison of major urinary proteins from the house mouse, Mus musculus domesticus, and the aboriginal mouse, Mus macedonicus. J. Chem. Ecol. (in press).Google Scholar
- Rozenfeld, F. M. (1987) Urine marking by male bank voles (Clethrionomys glareolus Schreber, 1780 - Microtidae) in relation with their social status. Mammalia 51, 476–477.Google Scholar