Advertisement

Volatile Mammalian Chemosignals: Structural and Quantitative Aspects

  • Milos V. Novotny
  • Helena A. Soini

Abstract

Current investigations of mammalian chemical signals are providing biologically useful information. Precision of profiling data has become substantially improved due to better sampling methodologies, selective detection techniques and vastly improved mass-spectrometric instrumentation. This, in turn, facilitates the use of powerful chemometric methodologies in evaluation of large data sets and a future integration of volatile profiling data into the systems biology knowledge.

Keywords

House Mouse Chemical Communication Asian Elephant Mouse Urine Preen Gland Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baltussen, E., Sandra, P., David, F. and Cramers, C. (1999) Stir bar extraction (SBSE), a novel extraction technique for aqueous samples: Theory and principles. J. Microcolumn Sep. 11, 737–747.CrossRefGoogle Scholar
  2. Beauchamp, G.K. and Yamazaki, K. (2003) Chemical signaling in mice. Biochem. Soc. Trans. 31, 141–151.Google Scholar
  3. Bicchi, C., Iori, C., Rubiolo, P. and Sandra, P. (2002) Headspace sorptive extraction (HSSE), stir bar sorptive extraction (SBSE) and solid phase microextraction (SPME) applied to the analysis of roasted Arabica coffee and coffee brew. J.Agric. Food Chem. 50, 449–459.PubMedCrossRefGoogle Scholar
  4. Bowers, W.S., Nault, L.R., Webb, R.E. and Dutky, S.R. (1972) Aphid alarm pheromone: isolation, idenfication, synthesis. Nature 177, 1121–1122.Google Scholar
  5. Brereton, R.G. (2003) Chemometrics: Data Analysis for the Laboratory and Chemical Plant, Wiley, Chichester, UK.Google Scholar
  6. Bronson, F.H. (1979) Reproductive ecology of the house mouse. Quart. Rev.Biol. 54, 265–299.PubMedCrossRefGoogle Scholar
  7. Burger, B.V., Tien, F.-C., LeRoux , M. and Mo, W.-P. (1996) Mammalian exocrine secretions: X. Constituents of preorbital secretion of grysbok, Raphicerus melanotis. J.Chem.Ecol. 22, 739–764.CrossRefGoogle Scholar
  8. Dixon, S.J., Brereton, R.G, Soini, H.A., Novotny, M.V. and Penn, D.J. (2007) An automated method for peak detection and matching in large gas chromatography-mass spectrometry data sets. Journal of Chemometrics In press.Google Scholar
  9. Dixon, S.J., Xu, Y., Brereton, R.G., Soini, H.A., Novotny, M.V., Oberzaucher, E., Grammer, K. and Penn, D.J. (2007) Pattern recognition of gas chromatography mass spectrometry of human volatiles in sweat to distinguish the sex of subjects and determine potential markers. Chemometrics Intell. Lab. Systems. In press.Google Scholar
  10. Goodwin, T.E., Eggert, M.S., House, S.J., Weddell, M.E., Schulte, B.A. and Rasmussen L.E.L. (2006) Insect pheromones and precursors in female African elephant urine. J.Chem. Ecol. 32, 1849–1853.PubMedCrossRefGoogle Scholar
  11. Greenwood, D.R., Comeskey, D., Hunt, M.B. and Rasmussen L.E.L. (2005) Chirality in elephant pheromones. Nature 438, 1097–1098.PubMedCrossRefGoogle Scholar
  12. Hurst, J.L. and Beynon, R.J. (2004) Scent wars: the chemobiology of competitive signalling in mice. BioEssays 26, 1281–1298.CrossRefGoogle Scholar
  13. Jemiolo, B., Harvey, S. and Novotny M. (1986) Promotion of Whitten effect in female mice by the synthetic analogs of male urinary constituents. Proc. Natl. Acad. Sci. USA 83, 4576–4579.CrossRefGoogle Scholar
  14. Jemiolo, B., Gubernick, D.J., Yoder, M., C. and Novotny, M. (1994) Chemical characterization of urinary volatile compounds of Peromyscus californicus, a monogamous biparental rodent. J. Chem. Ecol. 20, 2489–2500.CrossRefGoogle Scholar
  15. Jemiolo, B. and Novotny, M. (1994) Inhibition of sexual maturation in juvenile male and female mice by a chemosignal of female origin. Physiol. Behav. 55, 1119–1122.CrossRefGoogle Scholar
  16. Kikkawa, Y., Miura, S., Takahama, S., Wakana, S., Yamazaki, Y., Moriwaki, K., Shiroishi, T. and Yonekava, H. (2001) Microsatellite database for MSM/Ms and JF1/Ms, molossinus derived inbred strains. Mammalian Genome 12, 750–752.PubMedCrossRefGoogle Scholar
  17. Kitano, K. (2002) Systems biology: a brief overview. Science 295, 1662–1664.PubMedCrossRefGoogle Scholar
  18. Lowe, J.B. and Marth, J. D. (2003) A genetic approach to mammalian glycan function. Ann. Rev. Biochem. 72, 643–691.PubMedCrossRefGoogle Scholar
  19. Ma, W., Wiesler, D. and Novotny, M.V. (1999) Urinary volatile profiles of the deermouse (Peromyscus maniculatus) pertaining to gender and age. J. Chem. Ecol. 25, 417–431.CrossRefGoogle Scholar
  20. McCaffery, A.R. and Wilson, I.D. (Eds.) (1990) Chromatography and Isolation of Insect Hormones and Pheromones, Plenum, NYGoogle Scholar
  21. Novotny, M., Lee, M.L. and Bartle, K.D. (1974) Analytical aspects of the chromatographic headspace concentration methods using a porous polymer. Chromatographia 7, 333–338.CrossRefGoogle Scholar
  22. Novotny, M., Schwende, F.J., Wiesler, D., Jorgenson, J.W. and Carmack, M. (1984) Identification of a testosterone-dependent unique volatile constituent of male mouse urine: 7-exo-ethyl-5-methyl-6,8-dioxabicyclo[3.2.1]-3-octene. Experientia 40, 217–219.PubMedCrossRefGoogle Scholar
  23. Novotny, M., Harvey, S., Jemiolo, B. and Alberts, J. (1985) Synthetic pheomones that promote inter-male aggression in mice. Proc. Natl. Acad. Sci. USA 82, 2059–2061.PubMedCrossRefGoogle Scholar
  24. Novotny, M., Harvey, S. and Jemiolo, B. (1990) Chemistry of male dominance in the house mouse, Mus domesticus. Experientia 46, 109–113.PubMedCrossRefGoogle Scholar
  25. Novotny, M.V., Xie, T.-M., Harvey, S., Wiesler, D., Jemiolo, B. and Carmack, M. (1995) Stereoselectivity in mammalian chemical communication: male mouse pheromones. Experientia 51, 738–743.PubMedCrossRefGoogle Scholar
  26. Novotny, M.V. (2003) Pheromones, binding proteins and receptor responses in rodents. Biochem.Soc. Trans. 31, 117–122.PubMedCrossRefGoogle Scholar
  27. Novotny, M.V., Soini, H.A., Koyama, S., Wiesler, D., Bruce, K.E. and Penn , D.J. (2007) Chemical identification of MHC-influenced volatile compounds in mouse urine. I: Quantitative proportions of major chemosignals. J. Chem. Ecol. 33, 417–434.PubMedCrossRefGoogle Scholar
  28. Patris, B. and Baudoin, C. (1998) Female sexual preferences differ in Mus spicilegus and Mus musculus domesticus. Anim.Behav. 56, 1465–1470.PubMedCrossRefGoogle Scholar
  29. Patris, B. and Baudoin, C. (2000) A comparative study of parental care between two rodent species: implications for the mating system of the mound-building mouse Mus spicilegus. Behav.Processes 51, 35–43.PubMedCrossRefGoogle Scholar
  30. Pawliszyn, J. (1997) Solid-Phase Microextraction – Theory and Practice, Wiley, New York.Google Scholar
  31. Penn, D.J. and Potts, W. K. (1998) How do major histocompatibility complex genes influence odor and mating preferences? Adv.Immunol. 69, 411–436.PubMedCrossRefGoogle Scholar
  32. Penn, D.J. (2002) The scent of genetic compatibility: sexual selection and the major histocompatibility complex. Ethology 108, 1–21.CrossRefGoogle Scholar
  33. Penn, D.J., Oberzaucher, E., Grammer, K., Fischer, G., Soini, H.A., Wiesler, D., Novotny, M.V., Dixon, S.J., Xu, Y. and. Brereton, R.G. (2007) Individual and gender fingerprints in body odour. J.R. Soc. Interface 4, 331–340. .PubMedCrossRefGoogle Scholar
  34. Rasmussen, L.E.L., Lee, T.D., Roelofs, W.L., Zhang, A. and Daves, G.D. Jr. (1996) Insect pheromone in elephants. Nature 379, 684.PubMedCrossRefGoogle Scholar
  35. Schaal, B., Coureaud, G., Langlois, D., Giniès, C., Sémon, E. and Perrier, G. (2003) Chemical and behavioural characterization of the rabbit mammary pheromone. Nature 424, 68–72.PubMedCrossRefGoogle Scholar
  36. Schwende, F.J., Wiesler, D., Jorgenson, J.W., Carmack, M. and Novotny, M. (1986) Urinary volatile constituents of the house mouse (Mus musculus) and their endocrine dependency. J. Chem. Ecol. 12, 277–296.CrossRefGoogle Scholar
  37. Soini, H.A., Bruce, K.E., Wiesler, D., David, F., Sandra, P. and Novotny, M.V. (2005) Stir bar sorptive extraction: a new quantitative and comprehensive sampling technique for determination of chemical signal profiles from biological media J. Chem. Ecol., 31, 377–392.PubMedCrossRefGoogle Scholar
  38. Soini, H.A., Wiesler, D., Apfelbach, R., König, P., Vasilieva, N.Y. and Novotny, M.V. (2005) Comparative investigation of the volatile urinary profiles of different Phodopus hamster species. J. Chem. Ecol. 31, 1125–1143.PubMedCrossRefGoogle Scholar
  39. Soini, H.A., Bruce, K.E., Klouckova, I., Brereton, R.G., Penn, D.J. and Novotny, M.V. (2006) In-situ surface sampling of biological objects and preconcentration of their volatiles for chromatographic analysis. Anal. Chem. 78, 7161–2168.PubMedCrossRefGoogle Scholar
  40. Soini, H.A., Schrock, S.E., Bruce, K.E., Wiesler, D., Ketterson, E.D. and Novotny, M.V. (2007) Seasonal variation in volatile compound profiles of preen gland secretions of the dark-eyed junco (Junco hyemalis). J. Chem. Ecol. 33, 183–198.PubMedCrossRefGoogle Scholar
  41. Soini, H.A., Wiesler, D. and Novotny, M.V. (2006) Unpublished data.Google Scholar
  42. Soini, H.A., Wiesler, D., Bruce, K.E., Koyama, S., Ferón, C. Baudoin, B. and Novotny, M.V. (2006) Unpublished data.Google Scholar
  43. Wylie, P.L. and Quimby, B.D. (1989) Applications of gas chromatography with an atomic emission detector. J. High Resol. Chromatogr. 12, 813–818.CrossRefGoogle Scholar
  44. Zhang, J.X., Soini, H.A., Bruce, K.E., Wiesler, D., Woodley, S.K.,. Baum, M.J. and Novotny, M.V. (2005) Putative chemosignals of the ferret (Mustela furo) associated with individual and gender recognition Chem. Senses 30, 727–737.CrossRefGoogle Scholar
  45. Zhang, Z. and Pawliszyn, J. (1993) Headspace solid-phase microextraction. Anal.Chem. 65, 1843–1852.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media,LLC 2008

Authors and Affiliations

  • Milos V. Novotny
    • 1
  • Helena A. Soini
  1. 1.Department of ChemistryInstitute for Pheromone ResearchBloomingtonUSA

Personalised recommendations