Collagen pp 15-47 | Cite as

Collagen Diversity, Synthesis and Assembly

  • D.J.S. Hulmes


The vertebrate collagen superfamily now includes over 50 collagens and collagen-like proteins. Here, their different structures are described, as well as their diverse forms of supramolecular assembly. Also presented here are the various steps in collagen biosynthesis, both intracellular and extracellular, and the functions of the collagen-specific post-translational modifications. Assembly of collagen fibrils, both in vitro and in vivo, is reviewed, including the mechanisms that control this process and the interactions involved. Finally, recent developments in the supramolecular assembly of collagen-like peptides are discussed.


Osteogenesis Imperfecta Triple Helix Supramolecular Assembly Lysyl Oxidase Collagenous Domain 
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  • D.J.S. Hulmes

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