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Cytokines in CNS Inflammation and Disease

  • Malú G. Tansey
  • Tony Wyss-Coray

A growing number of increasingly sophisticated studies over the past two decades have implicated key immune regulatory factors in CNS function and disease. Chief among those factors are cytokines, which were originally described to regulate communication between immune cells. The purpose of this chapter is to review what is known regarding normal expression of key cytokines and their receptors in the CNS as well as their roles in development and disease. We will focus in particular on tumor necrosis factor α (TNF), transforming growth factor β (TGF-β), interleukin 1 (IL-1), IL-6, IL-10 and IL-12. We will discuss how these cytokines modulate not only normal CNS function but how abnormal cytokine signaling may contribute to major acute and chronic CNS diseases. We will rely heavily on studies in experimental mouse models that overproduce or ablate these cytokines and discuss the potential therapeutic benefits from ‘proof-of-concept’ targeting studies of specific cytokines in the treatment of CNS diseases.

Keywords

Tumor Necrosis Factor Traumatic Brain Injury Experimental Autoimmune Encephalomyelitis Dorsal Root Ganglion Neuron Cerebral Malaria 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Malú G. Tansey
  • Tony Wyss-Coray

There are no affiliations available

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