Hairy cell leukemia (HCL) is a rare, chronic, B-cell lymphoproliferative disorder with well-defined diagnostic criteria and successful treatment outcomes. HCL, classified as an indolent non-Hodgkin’s lymphoma in the World Health Organization (WHO) classification, typically presents with the diagnostic triad of pancytopenia, splenomegaly, and circulating cells with characteristic cytoplasmic villous projections. In this chapter, we will review insights pertaining to the historical aspects, epidemiology, pathogenesis, biology, clinical presentation, diagnosis, and treatments of this uncommon but fascinating hematologic entity.
KeywordsClin Oncol Chronic Lymphocytic Leukemia Minimal Residual Disease Hairy Cell Leukemia Hairy Cell
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