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Self-Assembled Monolayers with Molecular Gradients

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Book cover Combinatorial Methods for Chemical and Biological Sensors

Part of the book series: Integrated Analytical Systems ((ANASYS))

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Abstract

In recent years, biosensors and sensor arrays have developed into very important analytical tools, which found applications in many fields such as pharmaceutical (high-throughput) screening, medical diagnosis, or industrial process control. One of the major challenges for material research is the preparation of appropriate sensor surfaces, providing an interface with a high sensitivity and selectivity toward a given analyte. This chapter discusses some straightforward and flexible approaches to study structure and/or composition-function relationships and response characteristics of polymeric and molecular sensor materials. The controlled continuous deposition of self-assembled monolayers (SAMs), e.g. of substituted thiols or silanes, paves the way for the generation of molecular gradients on solid surfaces. These are useful for the preparation of interfaces with spatially controlled chemical composition and/ or physical properties. These tools can help to improve the selectivity and specificity of surfaces for biosensors and biochips. They can also be utilized for the study of fundamental protein adsorption and exchange phenomena.

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Authors and Affiliations

  1. Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93040, Regensburg, Germany

    Michael Schäferling

  2. Olympus Life Science Research Europa GmbH, Sauerbruchstr. 50, D-81377, Munich, Germany

    Michael Riepl

  3. University of Linköping, Division of Molecular Physics, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden

    Bo Liedberg

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  1. Michael Schäferling
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  3. Bo Liedberg
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Correspondence to Michael Schäferling .

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Editors and Affiliations

  1. Global Research Center, General Electric Company, 12309, Niskayuna, NY, USA

    Radislav A. Potyrailo

  2. Nanobiotechnology, Lausitz University of Applied Sciences, 01968, Senftenberg, Germany

    Vladimir M. Mirsky

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Schäferling, M., Riepl, M., Liedberg, B. (2009). Self-Assembled Monolayers with Molecular Gradients. In: Potyrailo, R.A., Mirsky, V.M. (eds) Combinatorial Methods for Chemical and Biological Sensors. Integrated Analytical Systems. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73713-3_3

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