Diversity-Oriented Fluorescence Library Approach for Novel Sensor Development
Fluorescence-based sensors are of extreme importance and have found applications in various fields. Although the demand for useful fluorescence sensors is acute, the conventional target-oriented approach has limited the scope and speed of novel sensor discovery. To make a breakthrough in this field, we introduced a new diversity-oriented fluorescence library approach (DOFLA) using combinatorial fluorescence compound libraries with huge structural diversity. Surprisingly, specific and unique sensors for a broad range of analytes from macromolecules including DNA, RNA, and proteins to signaling small molecules such as GTP, glutathione could be discovered from the library pools, demonstrating the universal applicability of this approach.
KeywordsCombinatorial Chemistry Fluorescence Sensor Pyridinium Salt Benzimidazolium Ring Sensor Discovery
The research and discoveries summarized herein were mainly based on the continuous contributions from the previous and present Chang group members. We are very grateful to all the individuals involved with these projects, with particular appreciations to: Dr. Gustavo R. Rosania, Dr. Shao Q. Yao, Dr. Jaeki Min, Dr. Jaewook Lee, Dr. Qian Li, Dr. Young-Hoon Ahn, Mr. Jun-Seok Lee, and Ms. Yunkyung Kim.
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