Ventilatory and Blood Pressure Responses to Isocapnic Hypoxia in OSA Patients
Obstructive sleep apnea (OSA) is a chronic medical condition resulting in chronic exposure to intermittent hypoxia (IH), which is correctable by continuous positive airway pressure (CPAP) therapy. Acute exposure to IH in healthy subjects affects respiratory control and vascular function (Foster, McKenzie, Milsom and Sheel 2005), but studies on the ventilatory response to hypoxia in OSA patients have yielded conflicting results and there have been few studies on the blood pressure response to hypoxia in this patient population. In addition, the effects of CPAP therapy on the blood pressure response to hypoxia have not been assessed. We hypothesized that the ventilatory and blood pressure response to hypoxia are enhanced in patients with OSA and that they are normalized following CPAP therapy.
KeywordsObstructive Sleep Apnea Continuous Positive Airway Pressure Obstructive Sleep Apnea Patient Blood Pressure Response Intermittent Hypoxia
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