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Modulation of Hering-Breuer Reflex by Ventrolateral Pons

  • Hui Wang
  • Heng Zhang
  • Gang Song
  • Chi-Sang Poon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

The vagally-mediated Hering-Breuer reflex (HBR) is known to be modulated by the classic pneumotaxic center in the dorsolateral pons. In this work, we investigated whether the HBR was also modulated by the ventrolateral pons (vl-pons). Experiments were performed on urethane anesthetized adult rats. The HBR was elicited by electrical stimulation of the vagus nerve and its strength was compared before and after electrical stimulation or microinjection of MK-801 (non-competitive NMDA receptor antagonist) at the vl-pons. We found that the inspiratory inhibition and expiratory prolongation effects of the HBR were strengthened after electrical stimulation at the vl-pons but were weakened after microinjecting MK-801. Results suggested that the vl-pons could influence the respiratory rhythm by modulating the strength of HBR via NMDA receptor-mediated neurotransmission.

Keywords

Electrical Stimulation Vagus Nerve Vagal Stimulation Respiratory Inhibition Phrenic Nerve Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Hui Wang
    • 1
  • Heng Zhang
    • 1
  • Gang Song
    • 1
    • 2
  • Chi-Sang Poon
    • 2
  1. 1.Laboratory of Respiratory Neurobiology, Institute of Physiology, School of MedicineShandong UniversityJinanPR China
  2. 2.Harvard-MIT Division of Health Sciences and TechnologyMassachusetts Institute of TechnologyCambridgeUK

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