Computational Model of TASK Channels and PKC-Pathway Dependent Serotonergic Modulatory Effects in Respiratory-Related Neurons

  • Tzu-Hsin B. Tsao
  • Robert J. Butera
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Hypoglossal motoneurons (HMs) receive serotonergic innervations from medullary raphe neurons and produce rhythmic discharge patterns closely associated with respiratory rhythm generated in the pre-Bötzinger complex (pBC). HM activity is subject to modulation by numerous factors including serotonin (5-HT), TRH, norepinephrine (NE), substance P (SP), pH, multiple protein kinases and phosphatases. In this present work, we introduce a computational HM model that facilitates the investigation of how neuromodulatory factors. such as 5-HT and pH, can affect HM activities.


Task Channel Motoneuron Excitability Calcium Induce Calcium Release Serotonergic Innervation Hypoglossal Motoneuron 
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Copyright information

© Springer 2008

Authors and Affiliations

  • Tzu-Hsin B. Tsao
    • 1
  • Robert J. Butera
    • 1
    • 2
  1. 1.Wallace H. Coulter GT/Emory Department of Biomedical EngineeringGeorgia Institute of TechnologyAtlantaUSA
  2. 2.School of Electrical and Computer EngineeringGeorgia Institute of TechnologyAtlantaUSA

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