The Retrotrapezoid Nucleus and Central Chemoreception

  • Patrice G. Guyenet
  • Douglas A. Bayliss
  • Daniel K. Mulkey
  • Ruth L. Stornetta
  • Thiago S. Moreira
  • Ana T. Takakura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Central respiratory chemoreception (CRC) is the mechanism by which brain pCO2 regulates breathing. The molecular and cellular basis of CRC is still poorly understood. In this review, we describe the properties of a cluster of pH-responsive neurons located in the retrotrapezoid region of the medulla oblongata and analyze whether these cells qualify as central respiratory chemoreceptors.


Ventrolateral Medulla Peripheral Chemoreceptor Solitary Tract Nucleus Central Chemoreception Central Chemosensitivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Amiel, J., Laudier, B., Attie-Bitach, T., Trang, H., de, Pontual, L., Gener, B., Trochet, D., Etchevers, H., Ray, P., Simonneau, M., Vekemans, M., Munnich, A., Gaultier, C. and Lyonnet, S. (2003) Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome. Nat. Genet. 33, 459–461.CrossRefPubMedGoogle Scholar
  2. Cream, C., Li, A. and Nattie, E. (2002) The retrotrapezoid nucleus (RTN): local cytoarchitecture and afferent connections. Respir. Physiolo. Neurobiol. 130, 121–137.CrossRefGoogle Scholar
  3. Feldman, J.L., Mitchell, G.S. and Nattie, E.E. (2003) Breathing: rhythmicity, plasticity, chemosensitivity. Annu. Rev. Neurosci. 26, 239–266.CrossRefPubMedGoogle Scholar
  4. Gaultier, C., Amiel, J., Dauger, S., Trang, H., Lyonnet, S., Gallego, J. and Simonneau, M. (2004) Genetics and early disturbances of breathing control. Pediatr. Res. 55, 729–733.CrossRefPubMedGoogle Scholar
  5. Gourine, A.V., Llaudet, E., Dale, N. and Spyer, K.M. (2005) ATP is a mediator of chemosensory transduction in the central nervous system. Nature 436, 108–111.CrossRefPubMedGoogle Scholar
  6. Guyenet, P.G., Mulkey, D.K., Stornetta, R.L. and Bayliss, D.A. (2005) Regulation of ventral surface chemoreceptors by the central respiratory pattern generator. J. Neurosci. 25, 8938–8947.CrossRefPubMedGoogle Scholar
  7. Li, A. and Nattie, E. (2002) CO2 dialysis in one chemoreceptor site, the RTN: stimulus intensity and sensitivity in the awake rat. Respir. Physiol. Neurobiol. 133, 11–22.CrossRefPubMedGoogle Scholar
  8. Loeschcke, H.H. (1982) Central chemosensitivity and the reaction theory. J. Physiol. 332, 1–24.PubMedGoogle Scholar
  9. Millhorn, D.E. and Eldridge, F.L. (1986) Role of ventrolateral medulla in regulation of respiratory and cardiovascular systems. J. Appl. Physiol. 61, 1249–1263.PubMedGoogle Scholar
  10. Mulkey, D.K., Mistry, A.M., Guyenet, P.G. and Bayliss, D.A. (2006) Purinergic P2 receptors modulate excitability but do not mediate pH sensitivity of RTN respiratory chemoreceptors. J. Neurosci. 26, 7230–7233.CrossRefPubMedGoogle Scholar
  11. Mulkey, D.K., Stornetta, R.L., Weston, M.C., Simmons, J.R., Parker, A., Bayliss, D.A. and Guyenet, P.G. (2004) Respiratory control by ventral surface chemoreceptor neurons in rats. Nat. Neurosci. 7, 1360–1369.CrossRefPubMedGoogle Scholar
  12. Nattie, E.E. (2001) Chemoreception and tonic drive in the retrotrapezoid nucleus (RTN) region of the awake rat: bicuculline and muscimol dialysis in the RTN. Adv. Exp. Med. Biol. 499, 27–32.PubMedGoogle Scholar
  13. Nattie, E.E. (2006) The retrotrapezoid nucleus and the ‘drive’ to breathe. J. Physiol. 572, 311.CrossRefPubMedGoogle Scholar
  14. Okada, Y., Chen, Z., Jiang, W., Kuwana, S. and Eldridge, F.L. (2002) Anatomical arrangement of hypercapnia-activated cells in the superficial ventral medulla of rats. J. Appl. Physiol. 93, 427–439.PubMedGoogle Scholar
  15. Rosin, D.L., Chang, D.A. and Guyenet, P. G. (2006) Afferent and efferent connections of the rat retrotrapezoid nucleus. J. Comp. Neurol., in press.Google Scholar
  16. Smith, J.C., Morrison, D.E., Ellenberger, H.H., Otto, M.R. and Feldman, J.L. (1989) Brainstem projections to the major respiratory neuron populations in the medulla of the cat. J. Comp. Neurol. 281, 69–96.CrossRefPubMedGoogle Scholar
  17. Spengler, C.M., Gozal, D. and Shea, S.A. (2001) Chemoreceptive mechanisms elucidated by studies of congenital central hypoventilation syndrome. Resp. Physiol. 129, 247–255.CrossRefGoogle Scholar
  18. Stornetta, R.L., Moreira, T.S., Takakura, A.C., Kang, B.J., Chang, D.A., West, G. H., Brunet, J.F., Mulkey, D.K., Bayliss, D.A. and Guyenet, P.G. (2006) Selective expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat. J. Neurosci. 26, 10305–10314.CrossRefPubMedGoogle Scholar
  19. Takakura, A.C., Moreira, T.S., Colombari, E., West, G.H., Stornetta, R.L. and Guyenet, P.G. (2006) Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats. J. Physiol. 572, 503–523.CrossRefPubMedGoogle Scholar

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© Springer 2008

Authors and Affiliations

  • Patrice G. Guyenet
  • Douglas A. Bayliss
  • Daniel K. Mulkey
  • Ruth L. Stornetta
  • Thiago S. Moreira
  • Ana T. Takakura

There are no affiliations available

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