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Plasticity in the Brain: Influence of Bilateral Carotid Body Resection (bCBR) on Central CO2 Sensitivity

  • Albert Dahan
  • Elise Sarton
  • Luc Teppema
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

We investigated the effect of bilateral carotid body resection (bCBR) in a patient with bilateral carotid body tumors on central CO2 sensitivity. We applied multiple square-wave changes in end-tidal CO2 and measured ventilation before the first surgery and at regular intervals for 3 years after surgery. The data were analyzed using a two-compartment model of the ventilatory control system. bCBR resulted in the loss of the fast response to CO2, and a sharp reduction in the magnitude of central CO2 sensitivity (a reduction of about 80% within 3 months after bCBR). Central CO2 sensitivity gradually increased to pre-operative values within 2 years after surgery. These observations are a strong indication for (1) the existence of a tonic influence from the peripheral chemoreceptors of the carotid bodies on central CO2 drive; (2) absence of any recovery of the peripheral drive after bCBR; and (3) neural plasticity causing the regeneration of central drive after bCBR.

Keywords

Carotid Body Ventilatory Response Carotid Body Tumor Peripheral Chemoreceptor SDHD Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Albert Dahan
    • 1
  • Elise Sarton
    • 1
  • Luc Teppema
    • 1
  1. 1.Department of AnesthesiologyLeiden University Medical CenterThe Netherlands

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