A Mathematical Model of pHi Regulation in Central CO2 - Chemoreception
In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pHi) while in non-chemosensitive neurons pHi recovery is observed. The precise mechanisms for the differential regulation of pHi recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pHi regulation in central CO2 chemoreception.
KeywordsModel Formulation Hypercapnic Acidosis Maintained Reduction Chemosensitive Neuron Intrinsic Buffer Capacity
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