Advertisement

A Mathematical Model of pHi Regulation in Central CO2 - Chemoreception

  • Juan M. Cordovez
  • Chris Clausen
  • Leon C. Moore
  • Irene C. Solomon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pHi) while in non-chemosensitive neurons pHi recovery is observed. The precise mechanisms for the differential regulation of pHi recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pHi regulation in central CO2 chemoreception.

Keywords

Model Formulation Hypercapnic Acidosis Maintained Reduction Chemosensitive Neuron Intrinsic Buffer Capacity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ritucci, N.A., Chambers-Kersh, L., Dean, J.B. and Putnam R.W. (1998) IntracellularpH regulation from chemosensitive and nonchemosensitive areas of the medulla. Am. J. Physiol. 275 (4 Pt 2), R1152–R1163.PubMedGoogle Scholar
  2. Ritucci, N.A., Dean, J.B. and Putnam R.W. (1997) Intracellular pH response to hypercapnia in neurons from chemosensitive areas of the medulla. Am. J. Physiol. 273 (1 Pt 2), R433–R441.PubMedGoogle Scholar
  3. Chang H. and Fujita T. (2001) A numerical model of acid-base transport in rat distal tubule. Am. J. Physiol. Renal Physiol. 281(2), F222–F243.PubMedGoogle Scholar
  4. Weinstein, A.M. (1995) A kinetically defined Na+/H+ antiporter within a mathematical model of the rat proximal tubule. J. Gen. Physiol. 105(5), 617–641.CrossRefPubMedGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Juan M. Cordovez
  • Chris Clausen
  • Leon C. Moore
  • Irene C. Solomon

There are no affiliations available

Personalised recommendations