A Computer Model of Mammalian Central CO2 Chemoreception

  • Mykyta Chernov
  • Robert W. Putnam
  • J. C. Leiter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

We developed a single compartment model of a mammalian CO2 sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO2 sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.


Firing Rate Potassium Channel Extracellular Acidification Hypercapnic Acidosis Task Channel 
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  1. Boron, W.F. and De Weer, P. (1976) Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors. J. Gen. Physiol. 67, 91–112.CrossRefPubMedGoogle Scholar
  2. Chernov, M.M., Daubenspeck, J.A., Denton, J.S., Pfeiffer, J.R., Putnam, R.W. and Leiter, J.C. (2007) A computational analysis of central CO2 chemosensitivity in Helix aspersa. Am. J. Physiol., 292, C278–291.CrossRefGoogle Scholar
  3. Denton, J.S., McCann, F.V. and Leiter, J.C. (2007) CO2 chemosensitivity in Helix aspersa: Three K+ currents mediate pH-sensitive neuronal activity. Am. J. Physiol., 292, C292–304.CrossRefGoogle Scholar
  4. Leem, C.H., Lagadic-Gossman, D. and Vaughan-Jones, R.D. (1999) Characterization of intracellular pH regulation in guinea-pig ventricular myocyte. J. Physiol. (Lond.) 517.1, 159–180.CrossRefGoogle Scholar
  5. Nottingham, S., Leiter, J.C., Wages, P., Buhay, S. and Erlichman, J.S. (2001) Developmental changes in intracellular pH regulation in medullary neurons of the rat. Am. J. Physiol. 281, R1940–R1951.Google Scholar
  6. Padanilam, B.J., Lu, T., Hoshi, T., Padanilam, B.A., Shibata, E.F. and Lee, H.-C. (2002) Molecular determinants of intracellular pH modulation of human Kv1.4 N-type inactivation. Molec. Pharmacol. 62, 127–134.CrossRefGoogle Scholar
  7. Putnam, R.W., Filosa, J.A. and Ritucci, N.A. (2004) Cellular mechanisms involved in CO2 and acid sensing in chemosensitive neurons. Am. J. Physiol. 287, C1493–C1526.CrossRefGoogle Scholar
  8. Ritucci, N.A., Dean, J.B. and Putnam, R.W. (1997) Intracellular pH response to hypercapnia in neurons from chemosensitive areas of the medulla. Am. J. Physiol. 273, R433–R441.PubMedGoogle Scholar
  9. Rybak, I., Paton, J.F.R. and Schwaber, J.S. (1997) Modeling neural mechanisms for genesis of respiratory rhythm and pattern. I. Models of respiratory neurons. J. Neurophysiol. 77, 1994–2006.PubMedGoogle Scholar
  10. Washburn, C.P., Sirois, J.E., Talley, E.M., Guyenet, P. and Bayliss, D.A. (2002) Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH- and halothane-sensitive K+ conductance. J. Neurosci. 22, 1256–1265.PubMedGoogle Scholar
  11. Williams, J.T., North, R.A. and Tokimasa, T. (1988) Inward rectification of resting and opitate-activated potassium currents in rat locus coeruleus neurons. J. Neurosci. 8, 4299–4306.PubMedGoogle Scholar

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© Springer 2008

Authors and Affiliations

  • Mykyta Chernov
  • Robert W. Putnam
  • J. C. Leiter

There are no affiliations available

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