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A Computer Model of Mammalian Central CO2 Chemoreception

  • Mykyta Chernov
  • Robert W. Putnam
  • J. C. Leiter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

We developed a single compartment model of a mammalian CO2 sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO2 sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.

Keywords

Firing Rate Potassium Channel Extracellular Acidification Hypercapnic Acidosis Task Channel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Mykyta Chernov
  • Robert W. Putnam
  • J. C. Leiter

There are no affiliations available

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