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Environmental Hyperoxia and Development of Carotid Chemoafferent Function

  • Gerald Bisgard
  • Julie Wenninger
  • Zunyi Wang
  • E. Burt OlsonJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Exposure to hyperoxia in the first few weeks of life causes life-long impairment of carotid chemoreceptor function in rats, e.g., depressed carotid sinus nerve (CSN) and phrenic nerve responses to acute hypoxia. We determined the maximal CSN responses of anesthetized adult rats to severe hypoxia (ventilation with 100% N2) or asphyxia (stopped ventilator) after 1, 2, and 4 weeks of postnatal hyperoxia (60% O2) (PNH). As with acute responses to hypoxic stimuli, we find that maximal CSN responses are significantly attenuated with severity of attenuation dependent on duration of PNH. We suggest that impaired carotid chemoafferent input produced by PNH could play a role in failure of arousal in severely hypoxic states occurring in infants and adults.

Keywords

Carotid Body Bronchopulmonary Dysplasia Acute Hypoxia Moderate Hypoxia Hyperoxic Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer 2008

Authors and Affiliations

  • Gerald Bisgard
    • 1
  • Julie Wenninger
    • 1
  • Zunyi Wang
    • 1
  • E. Burt OlsonJr.
    • 1
  1. 1.University of Wisconsin-MadisonMadison, WisconsinUSA

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