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Major Components of Endogenous Neurotransmission Underlying the Discharge Activity of Hypoglossal Motoneurons in vivo

  • Edward J. Zuperku
  • Ivo F. Brandes
  • Astrid G. Stucke
  • Antonio Sanchez
  • Francis A. Hopp
  • Eckehard A. Stuth
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Multibarrel micropipettes were used to simultaneously record unit activity and apply antagonists on individual inspiratory hypoglossal motoneurons (IHMNs) to determine the endogenous activation levels of NMDA, non-NMDA, GABAA and serotonin receptors responsible for the IHMN spontaneous discharge patterns in decerebrate dogs. IHMN activity is highly dependent on glutamatergic phasic and tonic drives, which are differentially mediated by the receptor subtypes. Endogenous serotonin significantly amplifies IHMN activity, while GABAergic gain modulation acts to attenuate activity. Thus, alterations in the neurotransmission of any of these systems could markedly alter neuronal output to target muscles.

Keywords

Discharge Pattern Gain Modulation Ejection Rate Medullary Reticular Formation Hypoglossal Motoneuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer 2008

Authors and Affiliations

  • Edward J. Zuperku
    • 1
  • Ivo F. Brandes
  • Astrid G. Stucke
  • Antonio Sanchez
  • Francis A. Hopp
    • 1
  • Eckehard A. Stuth
  1. 1.Zablocki VA Medical CenterMilwaukee

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