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Significance of Multiple Neurochemicals that Regulate Respiration

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 605))

Current efforts to characterize the neuronal mechanisms that underlie automatic breathing generally adopt a ‘minimalist’ approach. In this review, we survey three of the many neurochemicals that are known to be present in raphe neurons and may be involved in respiration. Specifically, we ask the question, ‘Is the minimalist approach consistent with the large number of neuronal types and neurochemicals found in respiratory centres?’

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References

  • Ballanyi, K., Lalley, P.M., Hoch, B. and Richter, D.W. (1997) cAMP-dependent reversal of opioid- and prostaglandin-mediated depression of the isolated respiratory network in newborn rats. J. Physiol. (Lond.) 504, 127–134.

    Article  CAS  Google Scholar 

  • Cao, Y., Matsuyama, K., Fujito, Y. and Aoki, M. (2006) Involvement of medullary GABAergic and serotonergic raphe neurons in respiratory control: Electrophysiological and immunohistochemical studies in rats. Neurosci. Res. 56(3), 322–331.

    Article  CAS  PubMed  Google Scholar 

  • Gatti, P.J., Llewellyn-Smith, I.J., Sun, Q.J., Chalmers, J. and Pilowsky, P.M. (1999) Substance P-immunoreactive boutons closely appose inspiratory protruder hypoglossal motoneurons in the cat. Brain Res. 834, 155–159.

    Article  CAS  PubMed  Google Scholar 

  • Guyenet, P.G., Stornetta, R.L., Bayliss, D.A. and Mulkey, D.K. (2005) Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors. Exp. Physiol. 90, 247–253.

    Article  CAS  PubMed  Google Scholar 

  • Holtman, J.R., Dick, T.E. and Berger, A.J. (1986) Involvement of serotonin in the excitation of phrenic motoneurons evoked by stimulation of the raphe obscurus. J. Neurosci. 6, 1185–1193.

    PubMed  Google Scholar 

  • Holtman, J.R., Jr. and King, K.A. (1994) Effect of activation of 5-HT1A receptors at the ventral medulla on phrenic nerve activity. Eur. J. Pharmacol. 253, 307–310.

    Article  CAS  PubMed  Google Scholar 

  • Holtman, J.R., Norman, W.P., Skirboll, L., Dretchen, K.L., Cuello, C., Visser, T.J., Hökfelt, T. and Gillis, R.A. (1984) Evidence for 5-hydroxytryptamine, substance P and thyrotropin-releasing hormone in neurons innervating the phrenic motor nucleus. J. Neurosci. 4, 1064–1071.

    PubMed  Google Scholar 

  • Holtman J.R., Jr. (1988) Immunohistochemical localization of serotonin- and substance P-containing fibers around respiratory muscle motoneurons in the nucleus ambiguus of the cat. Neuroscience 26, 169–178.

    Article  PubMed  Google Scholar 

  • Janczewski, W.A. and Feldman, J.L. (2006) Distinct rhythm generators for inspiration and expiration in the juvenile rat. J. Physiol. (Lond.) 570, 407–420.

    CAS  Google Scholar 

  • Lalley, P.M. (2003) Mu-opioid receptor agonist effects on medullary respiratory neurons in the cat: evidence for involvement in certain types of ventilatory disturbances. Am. J. Physiol. 285, R1287–R1304.

    CAS  Google Scholar 

  • Lalley, P.M., Benacka, R., Bischoff, A.M. and Richter, D.W. (1997) Nucleus raphe obscurus evokes 5-HT-1A receptor-mediated modulation of respiratory neurons. Brain Res. 747, 156–159.

    Article  CAS  PubMed  Google Scholar 

  • Li, A. and Nattie, E. (2006) Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability. J. Physiol. (Lond.) 570, 385–96.

    CAS  Google Scholar 

  • Li, Q., Goodchild, A.K., Seyedabadi, M. and Pilowsky, P.M. (2005) Pre-protachykinin A mRNA is colocalized with tyrosine hydroxylase-immunoreactivity in bulbospinal neurons. Neuroscience 136, 205–216.

    Article  CAS  PubMed  Google Scholar 

  • Lonergan, T., Goodchild, A.K., Christie, M.J. and Pilowsky, P.M. (2003a) Mu opioid receptors in rat ventral medulla: effects of endomorphin-1 on phrenic nerve activity. Respir. Physiol. Neurobiol. 138, 165–178.

    Article  CAS  PubMed  Google Scholar 

  • Lonergan, T., Goodchild, A.K., Christie, M.J. and Pilowsky, P.M. (2003b) Presynaptic delta opioid receptors differentially modulate rhythm and pattern generation in the ventral respiratory group of the rat. Neuroscience 121, 959–973.

    Article  CAS  PubMed  Google Scholar 

  • Lovett-Barr, M.R., Mitchell, G.S., Satriotomo, I. and Johnson, S.M. (2006) Serotonin-induced in vitro long-term facilitation exhibits differential pattern sensitivity in cervical and thoracic inspiratory motor output. Neuroscience 142, 885–892.

    Article  CAS  PubMed  Google Scholar 

  • Makeham, J.M., Goodchild, A.K. and Pilowsky, P.M. (2005) NK1 receptor activation in rat rostral ventrolateral medulla selectively attenuates somato-sympathetic reflex while antagonism attenuates sympathetic chemoreflex. Am. J. Physiol. 288, R1707–R1715.

    CAS  Google Scholar 

  • McKay, L.C., Janczewski, W.A. and Feldman, J.L. (2005) Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons. Nat. Neurosci. 8, 1142–1144.

    Article  CAS  PubMed  Google Scholar 

  • Mitchell, G.S., Baker, T.L., Nanda, S.A., Fuller, D.D., Zabka, A.G., Hodgeman, B.A., Bavis, R.W., Mack, K.J. and Olson, E.B., Jr. (2001) Invited review: Intermittent hypoxia and respiratory plasticity. J. Appl. Physiol. 90, 2466–2475.

    CAS  PubMed  Google Scholar 

  • Nattie, E.E., Li, A., Richerson, G. and Lappi, D.A. (2004) Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo. J. Physiol. (Lond.) 556, 235–253.

    Article  CAS  Google Scholar 

  • Pagliardini, S., Adachi, T., Ren, J., Funk, G.D. and Greer, J.J. (2005) Fluorescent tagging of rhythmically active respiratory neurons within the pre-Botzinger complex of rat medullary slice preparations. J. Neurosci. 25, 2591–2596.

    Article  CAS  PubMed  Google Scholar 

  • Pilowsky, P.M., de Castro, D., Llewellyn-Smith, I.J., Lipski, J. and Voss, M.D. (1990) Serotonin immunoreactive boutons make synpases with feline phrenic motoneurons. J. Neurosci. 10, 1091–1098.

    CAS  PubMed  Google Scholar 

  • Richerson, G.B., Wang, W., Hodges, M.R., Dohle, C.I. and Diez-Sampedro, A. (2005) Homing in on the specific phenotype(s) of central respiratory chemoreceptors. Exp. Physiol. 90, 259–266.

    Article  CAS  PubMed  Google Scholar 

  • Rybak, I.A., Shevtsova, N.A., St-John, W.M., Paton, J.F. and Pierrefiche, O. (2003) Endogenous rhythm generation in the pre-Botzinger complex and ionic currents: modelling and in vitro studies. Eur. J. Neurosci. 18, 239–257.

    Article  PubMed  Google Scholar 

  • Schwarzacher, S.W., Pestean, A., Gunther, S. and Ballanyi, K. (2002) Serotonergic modulation of respiratory motoneurons and interneurons in brainstem slices of perinatal rats. Neuroscience 115, 1247–1259.

    Article  CAS  PubMed  Google Scholar 

  • Steinbusch, H.W.M. (1984) Serotonin-immunoreactive neurons and their projections in the CNS. In: A. Björklund, T. Hökfelt and M. J. Kuhar (Eds.), Handbook of Chemical Neuroanatomy, Elsevier Science, pp. 68–125.

    Google Scholar 

  • Sun, Q.J., Berkowitz, R.G., Goodchild, A.K. and Pilowsky, P.M. (2002) Serotonin inputs to inspiratory laryngeal motoneurons in the rat. J. Comp. Neurol. 451, 91–98.

    Article  CAS  PubMed  Google Scholar 

  • Tryba, A.K., Pena, F. and Ramirez, J.M. (2006) Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors. J. Neurosci. 26, 2623–2634.

    Article  CAS  PubMed  Google Scholar 

  • Verner, T.A., Goodchild, A.K. and Pilowsky, P.M. (2004) A mapping study of cardiorespiratory responses to chemical stimulation of the midline medulla oblongata in ventilated and freely breathing rats. Am. J. Physiol. 287, R411–R421.

    Article  CAS  Google Scholar 

  • Voss, M.D., de Castro, D., Lipski, J., Pilowsky, P.M. and Jiang, C. (1990) Serotonin immunoreactive boutons form close appositions with respiratory neurons of the dorsal respiratory group in the cat. J. Comp. Neurol. 295, 208–218.

    Article  CAS  PubMed  Google Scholar 

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Pilowsky, P.M. et al. (2008). Significance of Multiple Neurochemicals that Regulate Respiration. In: Poulin, M.J., Wilson, R.J.A. (eds) Integration in Respiratory Control. Advances in Experimental Medicine and Biology, vol 605. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73693-8_47

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