Control of Genioglossus Muscle by Sleep State-Dependent Neuromodulators

  • Richard L. Horner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Pharyngeal muscle tone decreases in sleep and this predisposes some individuals to obstructive sleep apnea. This review summarizes the control of the genioglossus muscle by sleep-state dependent neuromodulators at the hypoglossal motor nucleus, the source of motor output to the genioglossus muscle of the tongue. Knowledge of such mechanisms is relevant to identifying and developing new strategies to augment pharyngeal muscle activity in sleep, potentially as treatments for obstructive sleep apnea.


Obstructive Sleep Apnea Obstructive Sleep Apnea Patient Genioglossus Muscle Respiratory Muscle Activity Hypoglossal Motor 
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Copyright information

© Springer 2008

Authors and Affiliations

  • Richard L. Horner
    • 1
  1. 1.Departments of Medicine and PhysiologyUniversity of TorontoTorontoCanada

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