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Effects of Systemic Administration of Mirtazapine on Respiratory Muscle Activity in Sleeping Rats

  • Y.-L. Chou
  • J. T. Stanley
  • K. Vujisic
  • R. B. Berry
  • P. W. Davenport
  • J. J. Anderson
  • L. F. Hayward
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Mirtazapine (MIRT) is an antidepressant with mixed noradrenergic and serotonergic effects in central nervous system. The present study was undertaken to assess whether MIRT can stimulate genioglossus muscle (GG) activity in the conscious, behaving rat. Nine male rats were chronically instrumented with GG and neck muscle EMG electrodes. EEG electrodes were implanted to acquire sleep stage. Results demonstrated a dose-dependent effect of MIRT on GG activity during sleep, although no changes reached statistical significance. Low dose MIRT (0.1 mg/kg) showed a slight increase in GG phasic activity. In contrast, higher doses of MIRT (0.5–1.0 mg/kg) tended to decrease GG activity relative to vehicle, in addition to decreasing total sleep time.

Keywords

Total Sleep Time Active Wake Time Post Injection Respiratory Muscle Activity Neck Muscle Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Y.-L. Chou
  • J. T. Stanley
  • K. Vujisic
  • R. B. Berry
  • P. W. Davenport
  • J. J. Anderson
  • L. F. Hayward

There are no affiliations available

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