Respiratory Long-Term Facilitation: Too Much or Too Little of a Good Thing?

  • Safraaz Mahamed
  • Gordon S. Mitchell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Respiratory long-term facilitation (LTF), a prolonged augmentation of respiratory motor output, is induced by intermittent hypoxia in anesthetized or sleeping rats (and humans in limited conditions). Whether such augmentation in the controller response is of physiological benefit in terms of ventilatory stability remains uncertain; its impact on ventilatory stability will be determined to some extent by its effects on CO2 chemoreflex loop gain. We used integrated nerve responses in a rat model of LTF to assess chemoreflex parameters related to breathing stability. In this model, LTF decreases chemoreflex threshold but increases chemoreflex gain. Whereas a decreased chemoreflex threshold would promote ventilatory stability, increased chemoreflex gain represents a destabilizing influence. Based on these considerations alone, the impact of respiratory LTF on respiratory stability remains unclear.


Obstructive Sleep Apnea Intermittent Hypoxia Loop Gain Recruitment Threshold Destabilize Influence 
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© Springer 2008

Authors and Affiliations

  • Safraaz Mahamed
  • Gordon S. Mitchell

There are no affiliations available

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