Pulmonary gas exchange can be investigated at different scales of interest. Our approach is to couple models of gas exchange to anatomically-detailed models of the airway and pulmonary vascular trees. We are linking a hierarchy of models from the capillary segment up to the whole lung, so that a change in the detailed small-scale behaviour has a flow-on effect to function at a larger scale. The anatomically-based models will be used to understand how regional perturbations to the structure or function of the airway and vascular trees and the state of health of the functional tissue affect gas exchange. We are interested in the degree to which the system can be perturbed before it is detected by standard laboratory measures.
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References
Ben-Tal, A. (2006) Simplified models for gas exchange in the human lungs. Journal of Theoretical Biology 238(2), 474–495.
Burrowes, K.S., Tawhai, M.H and Hunter, P.J. (2003) Modeling RBC and neutrophil distribution through an anatomically based pulmonary capillary network. Annals of Biomedical Engineering 32(4), 585–595.
Felici, M., Filoche, M., Straus, C., Similowski, T. and Sapoval, B. (2005) Diffusional screening in real 3D human acini–a theoretical study. Respiratory Physiology and Neurobiology 145(2–3), 279–293.
Hedges, K.L., Hunter, P.J. and Tawhai, M.H. (2006) Image-based computational model of a breathing lung. Proceedings of the American Thoracic Society (PATS), abstract, [Online], 3, A876. Available: http://www.abstracts2view.com/ats06/sessionindex.php [7 September 2006].
Holland, R.A.B., van Hezewijk, W. and Zubzanda, J. (1977) Velocity of oxygen uptake by partly saturated adult and fetal human red cells. Respiration Physiology 29(3), 303–314.
Liu, C.H., Niranjan, S.C., Clark, J.W., Jr., San, K.Y., Zwischenberger, J.B. and Bidani, A. (1998) Airway mechanics, gas exchange, and blood flow in a nonlinear model of the normal human lung. Journal of Applied Physiology 84(4), 1447–1469.
Poole, D.C and Musch, T.I. (2000) Pulmonary and Peripheral Gas Exchange During Exercise. In: J. Roca, R. Rodriguez-Roisin and P.D. Wagner (Eds.), Pulmonary and Peripheral Gas Exchange in Health and Disease. Marcel Dekker, Inc., New York, pp. 469–523.
Roughton, F.J.W. and Forster, R.E. (1957) Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. Journal of Applied Physiology 11, 290–302.
Tawhai, M.H. and Hunter, P.J. (2001) Characterising respiratory airway gas mixing using a lumped parameter model of the pulmonary acinus. Respiration Physiology 127(2–3), 241–248.
Weibel, E.R. (1963) Morphometry of the Human Lung. Springer-Verlag, Berlin.
Weibel, E.R (1997) Design and morphometry of the pulmonary gas exchanger. In: R.G. Crystal, J.B. West, E.R. Weibel, and P.J. Barnes (Eds.), The Lung; Scientific Foundations ( nd edition). Lippincott-Raven Publishers, Philadelphia, pp. 1147–1157.
West, J.B. (2000) Respiratory Physiology: The Essentials (6 th edition). Lippincott Williams & Wilkins, Philadelphia, PA.
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Swan, A., Hunter, P., Tawhai, M. (2008). Pulmonary Gas Exchange in Anatomically-Based Models of the Lung. In: Poulin, M.J., Wilson, R.J.A. (eds) Integration in Respiratory Control. Advances in Experimental Medicine and Biology, vol 605. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73693-8_32
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