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Control of the Exercise Hyperpnea: The Unanswered Question

  • Brian J. Whipp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

At the first of what is now known as, the “Oxford Conferences,” Fred Grodins referred to the mechanism of the exercise hyperpnea, as “The Ultra Secret.” I have chosen to sub-title my presentation, “The Unanswered Question” (with apologies to Charles Ives) in the hope that even if the answer does not eventuate then at least the nature of the essential question will. But space constraints allow only one theme to be developed and that only for moderate exercise. And, as it is the “Oxford Conference,” I have chosen one initially adumbrated by one of Oxford's luminaries, C.G. Douglas; one, in my judgment, that is under-appreciated. In his 1927 Lancet review, Douglas (1927) describes an important study: “in which we followed in detail the behaviour of the breathing after the ingestion of a considerable quantity of sugar by a person at complete rest … The volume of air breathed per minute showed a perfectly definite rise and fall which ran closely parallel to the change in CO 2 production, and the parallelism became still more obvious if the effective amount of air was calculated as distinguished from the total amount of air breathed.”

Keywords

Unanswered Question Moderate Exercise Ventilatory Control Central Command Physiological Dead Space 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adams, L., Frankel, H., Garlick, J., Guz, A., Murphy, K. and Semple, S.J. (1984) The role of spinal cord transmission in the ventilatory response to exercise in man. J. Physiol. 355, 85–97.PubMedGoogle Scholar
  2. Brittain, C.J., Rossiter, H.B., Kowalchuk, J.M. and Whipp, B.J. (2001) Effect of prior metabolic rate on the kinetics of oxygen uptake during moderate-intensity exercise. Eur. J. Appl. Physiol. 86, 125–134.CrossRefPubMedGoogle Scholar
  3. Casaburi, R., Whipp, B.J., Wasserman, K. and Stremel, R.W. (1978) Ventilatory control characteristics of the exercise hyperpnea as discerned from dynamic forcing techniques. Chest 73S, 280–283.Google Scholar
  4. Dempsey, J.A. (2006) Challenges for future research in exercise physiology as applied to the respiratory system. Exerc. Sport Sci. Rev. 34, 92–98.CrossRefPubMedGoogle Scholar
  5. Douglas, C.G. (1927) Co-ordination of the respiration and circulation with variations in bodily activity. Lancet 2, 213–218.CrossRefGoogle Scholar
  6. Eldridge, F.L. and Waldrop, T.G. (1991) Neural control of breathing. In: B.J. Whipp and K. Wasserman (Eds.), Pulmonary Physiology and Pathophysiology of Exercise. Dekker, New York, pp. 309–370.Google Scholar
  7. Farhi, L.E. and Rahn H. (1955) Gas stores in the body and the unsteady state. J. Appl. Physiol. 7, 472–484.PubMedGoogle Scholar
  8. Haouzi, P. (2006) Theories on the nature of the coupling between ventilation and gas exchange during exercise. Resp. Physiol. Neurobiol. 151, 267–279.CrossRefGoogle Scholar
  9. Hughson, R.L., and Morrissey, M. (1982) Delayed kinetics of respiratory gas exchange in the transition from prior exercise. J. Appl. Physiol. 52, 921–929.PubMedGoogle Scholar
  10. Huszczuk, A., Whipp, B.J., Oren, A., Shors, E.C., Pokorski, M., Nery, L.E. and Wasserman, K. (1986) Ventilatory responses to partial cardiopulmonary bypass at rest and exercise in the dog. J. Appl. Physiol. 61, 575–583.PubMedGoogle Scholar
  11. Kemp, G. (2005) Lactate accumulation, proton buffering and ph change in ischemically exercising muscle. Am. J. Physiol. 289, R895–R901.Google Scholar
  12. Krishnan, B., Zintel, T., McParland, C. and Gallagher, C.G. (1996) Lack of importance of respiratory muscle load in ventilatory regulation during heavy exercise in humans. J. Physiol. 490, 537–50.PubMedGoogle Scholar
  13. Lamarra, N., Whipp, B.J. and Ward, S.A. (1988) Physiological inferences from intra-breath measurement of pulmonary gas exchange. Proc. Ann. Internat. Conf. I.E.E.E. Eng. Med. Biol. Soc., New Orleans, pp. 825–826.Google Scholar
  14. Poon, C.S., Ward, S.A. and Whipp B.J. (1987) Influence of inspiratory assistance on ventilatory control during moderate exercise. J. Appl. Physiol. 62, 551–560.PubMedGoogle Scholar
  15. Taylor, R. and Jones, N.L. (1979) The reduction by training of CO2 output during exercise. Eur. J. Cardiol. 9, 53–62.PubMedGoogle Scholar
  16. Wasserman, K., Stringer, W., Casaburi, R. and Zhang, Y.Y. (1997) Mechanism of exercise hyperkalemia: an alternate hypothesis J. Appl. Physiol. 83, 631–643.PubMedGoogle Scholar
  17. Wasserman, K., Whipp, B.J., Casaburi, R., Beaver, W.L. and Brown, H.V. (1977) CO2 flow to the lungs and ventilatory control. In: J.A. Dempsey and C.E. Reed (Eds.), Muscular Exercise and the Lung. University of Wisconsin Press, Madison, pp. 105–135.Google Scholar
  18. Whipp, B.J. and Ward, S.A. (1982) Cardiopulmonary coupling during exercise. J. Exp. Biol. 100, 175–193.PubMedGoogle Scholar
  19. Whipp, B.J. and Ward, S.A. (1991) The coupling of ventilation to pulmonary gas exchange during exercise. In: B.J. Whipp and K. Wasserman (Eds.), Pulmonary Physiology and Pathophysiology of Exercise. Dekker, New York, pp. 271–307.Google Scholar

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© Springer 2008

Authors and Affiliations

  • Brian J. Whipp
    • 1
  1. 1.Institute of Membrane & Systems BiologySport & Exercise Sciences University of LeedsLeedsUnited Kingdom

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