Advertisement

Quantitative Analysis of the Oxygen Transfer in the Human Acinus

  • Marcel Filoche
  • André A. Moreira
  • José S. AndradeJr.
  • Bernard Sapoval
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

The gas transport in the acinus is limited at rest by the finite oxygen diffusivity. Although the simplest steady-state model of diffusion permits understanding a number of observations, it fails to quantitatively fit the value of the absolute flux of oxygen at rest and exercise. In this paper, we show that the binding of oxygen to hemoglobin modifies these values only slightly. In contrast, the dynamics of breathing have a strong effect and allow recovery to known experimental values for oxygen transfer.

Keywords

Oxygen Transfer Total Flux Screen Effect Oxygen Flux Breathing Frequency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Felici, M. (2003) Physique du transport diffusif de l’oxygène dans le poumon humain, PhD Thesis, Ecole Polytechnique.Google Scholar
  2. Felici, M., Filoche, M., Straus C., Similovski T. and Sapoval B. (2005) Diffusional screening in real 3D human acini–a theoretical study. Resp. Phys. Neurob. 145 (2–3), 279–293 and references therein.CrossRefGoogle Scholar
  3. Keener, J. and Sneyd, J. (1998) Mathematical Physiology. J.E. Marsden, L. Sirovich and S. Wiggins (Eds.), Springer-Verlag, New York.Google Scholar
  4. Kitaoka, H., Tamura, S. and Takaki, R. (2000) A three-dimensional model of the human pulmonary acinus, J. Appl. Physiol. 88, 2260–2268.PubMedGoogle Scholar
  5. Sapoval, B., Filoche M. and Weibel, E.R. (2002) Smaller is better-but not too small: a physical scale for the design of the mammalian pulmonary acinus. Proc. Nat. Acad. Sci. 99, 10411–10416 and references therein.CrossRefPubMedGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Marcel Filoche
    • 1
    • 2
  • André A. Moreira
    • 3
  • José S. AndradeJr.
    • 1
    • 3
  • Bernard Sapoval
    • 1
    • 2
  1. 1.Physique de la Matière Condensée, Ecole PolytechniqueCNRSPalaiseauFrance
  2. 2.Ecole Normale SupérieureC.N.R.S., Centre de Mathématiques et de leurs ApplicationsCachanFrance
  3. 3.Departamento de FísicaUniversidade Federal do CearáFortaleza, CearáBrazil

Personalised recommendations