Modulation of Perinatal Respiratory Rhythm by GABAA- and Glycine Receptor-mediated Chloride Conductances
Previous studies demonstrated that chloride-mediated conductances via GABA and glycine strongly modulate neonatal respiratory rhythmogenesis. However, contradictory results were reported (Brockhaus and Ballanyi 1998; Ritter and Zhang 2000). Specifically, whether GABAA- and glycine receptor-mediated actions are depolarizing/hyperpolarizing resulting in stimulation/depression of respiratory frequency in neonates was unclear. Further, the prenatal period had not been studied. Thus, we systematically investigated the actions of chloride-mediated conductances on respiratory rhythmogenesis in perinatal rats from the time of inception of fetal inspiratory drive through to the newborn period (Ren and Greer 2006).
KeywordsRespiratory Frequency Respiratory Neuron Inspiratory Neuron Versus Rest Neocortical Pyramidal Neuron
Unable to display preview. Download preview PDF.