Modulation of Perinatal Respiratory Rhythm by GABAA- and Glycine Receptor-mediated Chloride Conductances

  • Jun Ren
  • John J. Greer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Previous studies demonstrated that chloride-mediated conductances via GABA and glycine strongly modulate neonatal respiratory rhythmogenesis. However, contradictory results were reported (Brockhaus and Ballanyi 1998; Ritter and Zhang 2000). Specifically, whether GABAA- and glycine receptor-mediated actions are depolarizing/hyperpolarizing resulting in stimulation/depression of respiratory frequency in neonates was unclear. Further, the prenatal period had not been studied. Thus, we systematically investigated the actions of chloride-mediated conductances on respiratory rhythmogenesis in perinatal rats from the time of inception of fetal inspiratory drive through to the newborn period (Ren and Greer 2006).


Respiratory Frequency Respiratory Neuron Inspiratory Neuron Versus Rest Neocortical Pyramidal Neuron 
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Copyright information

© Springer 2008

Authors and Affiliations

  • Jun Ren
    • 1
  • John J. Greer
    • 1
  1. 1.Department of Physiology, Centre for NeuroscienceUniversity of AlbertaEdmonton, AlbertaCanada

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