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Modulation of Perinatal Respiratory Rhythm by GABAA- and Glycine Receptor-mediated Chloride Conductances

  • Jun Ren
  • John J. Greer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Previous studies demonstrated that chloride-mediated conductances via GABA and glycine strongly modulate neonatal respiratory rhythmogenesis. However, contradictory results were reported (Brockhaus and Ballanyi 1998; Ritter and Zhang 2000). Specifically, whether GABAA- and glycine receptor-mediated actions are depolarizing/hyperpolarizing resulting in stimulation/depression of respiratory frequency in neonates was unclear. Further, the prenatal period had not been studied. Thus, we systematically investigated the actions of chloride-mediated conductances on respiratory rhythmogenesis in perinatal rats from the time of inception of fetal inspiratory drive through to the newborn period (Ren and Greer 2006).

Keywords

Respiratory Frequency Respiratory Neuron Inspiratory Neuron Versus Rest Neocortical Pyramidal Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ben Ari, Y., Khazipo, V, Leinekugel, X., Caillard, O. and Gaiarsa, J.L. (1997) GABAA, NMDA and AMPA receptors: developmentally regulated menage a trois. Trends Neurosci. 20, 523–529.CrossRefPubMedGoogle Scholar
  2. Brockhaus, J. and Ballanyi, K. (1998) Synaptic inhibition in the isolated respiratory network of neonatal rats. Eur. J. Neurosci. 10, 3823–3839.CrossRefPubMedGoogle Scholar
  3. DeFazio, R.A., Keros, S., Quick, M.W. and Hablitz, J.J. (2000) Potassium-coupled chloride cotransport controls intracellular chloride in rat neocortical pyramidal neurons. J. Neurosci. 20, 8069–8076.PubMedGoogle Scholar
  4. Kaila, K. (1994) Ionic basis of GABAA receptor channel function in the nervous system. Prog. Neurobiol. 42, 489–537.CrossRefPubMedGoogle Scholar
  5. Payne, J.A. (1997) Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation. Am. J. Physiol. 273, C1516–C1525.PubMedGoogle Scholar
  6. Ren, J. and Greer, J.J. (2006) Modulation of respiratory rhythmogenesis by chloride mediated conductances during the perinatal period. J. Neurosci. 26, 3721–3730.CrossRefPubMedGoogle Scholar
  7. Ritter, B. and Zhang, W. (2000) Early postnatal maturation of GABAA-mediated inhibition in the brainstem respiratory rhythm-generating network of the mouse. Eur. J. Neurosci. 12, 2975–2984.CrossRefPubMedGoogle Scholar
  8. Rivera, C., Voipio, J., Payne, J.A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M. and Kaila, K. (1999) The K+/Cl cotransporter KCC2 tenders GABA hyperpolarizing during neuronal maturation. Nature 397, 251–255.CrossRefPubMedGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Jun Ren
    • 1
  • John J. Greer
    • 1
  1. 1.Department of Physiology, Centre for NeuroscienceUniversity of AlbertaEdmonton, AlbertaCanada

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