Neurodevelopmental Abnormalities in the Brainstem of Prenatal Mice Lacking the Prader-Willi Syndrome Gene Necdin
Necdin (Ndn) is one of the paternally-expressed genes located on chromosome 15q11–q13, which is deleted in Prader-Willi Syndrome (PWS). Typical symptoms of this neurodevelopmental disorder are represented by hypotonia, failure to thrive, hyperphagia leading to severe obesity, somatosensory deficits, behavioral problems and mild-to-moderate mental retardation (Goldstone 2004). Further, PWS is associated with respiratory instability in the newborn period, associated with sleep apneas and blunted chemosensitivity (Nixon and Brouilette 2002).
KeywordsRespiratory Rhythm Ventrolateral Medulla Axonal Tract Nucleus Ambiguus Neurodevelopmental Abnormality
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