Reactive oxygen species (ROS) likely play a role in the hypoxic ventilatory response. We determined whether hypoxic responses were influenced by alterations in cellular redox status induced by reductions in superoxide dismutase-1 (SOD-1) activity, a cytosolic anti-oxidant enzyme. Using whole-body, continuous-flow plethysmography, we compared ventilatory responses to moderate hypoxia (10% inspired O2) of Sod1 +/+, +/− and −/− postnatal day 4 (P4) littermates. Sod1 +/− neonates exhibited a consistently lower breathing frequency than their wild-type littermates, regardless of inspired O2 level. While SOD-1 deficiency had no effect on the magnitude of the ventilatory response during hypoxia, it did compromise stability of breathing in the post-hypoxic period. Our results suggest SOD-1 stimulates ventilation and helps stabilize breathing after a hypoxic perturbation.
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Cummings, K.J., Kalf, D., Moore, S., Miller, B.J., Jirik, F.R., Wilson, R.J.A. (2008). Superoxide Dismutase-1 Influences the Timing and Post-hypoxic Stability of Neonatal Breathing. In: Poulin, M.J., Wilson, R.J.A. (eds) Integration in Respiratory Control. Advances in Experimental Medicine and Biology, vol 605. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73693-8_23
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DOI: https://doi.org/10.1007/978-0-387-73693-8_23
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