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Two Modes of Respiratory Rhythm Generation in the Newborn Rat Brainstem-Spinal Cord Preparation

  • Hiroshi Onimaru
  • Ikuo Homma
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Two respiration-related rhythm generators, the pre-Bötzinger complex inspiratory and the parafacial pre-inspiratory rhythm generators, have been identified in the medulla of rodents that produce intrinsic periodic bursts. Although both generators can be independently active under specific conditions, they interact as a coupled oscillator system to regulate the respiratory rhythm. Here, we summarize different mechanisms of modulation of the respiratory rhythm in the brainstem-spinal cord preparation of newborn rats and discuss factors determining rhythm generator dominance. We show two different modes of respiratory rhythm generation in the brainstem-spinal cord preparation that depends on the background stimulation level.

Keywords

Respiratory Rhythm Ventrolateral Medulla Respiratory Neuron Respiratory Network Ventral Respiratory Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer 2008

Authors and Affiliations

  • Hiroshi Onimaru
  • Ikuo Homma

There are no affiliations available

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