The effects of intravenous endothelin-1 (ET-1) on the ventilatory response to hypoxia were studied in healthy humans. Nine volunteers were each exposed twice to 4 hr eucapnic hypoxia. They received a continuous infusion of ET-1 during the ET-1 protocol and an infusion of saline during the control protocol. Plasma ET-1 levels and an index of ventilation were measured regularly. Hypoxia caused a rise in plasma ET-1 in the control protocol. Hypoxia also caused the index of ventilation to increase in both protocols, and this increase was greater in the ET-1 protocol than in the control protocol. These results are consistent with the hypothesis that ET-1 plays a role in controlling the ventilatory response to hypoxia in man.
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References
Chen, J., He, L., Dinger, B., Stensaas, L. and Fidone, S. (2002). Role of endothelin and endothelin A-type receptor in adaptation of the carotid body to chronic hypoxia. Am. J. Physiol. 282, L1314–L1323.
Chen, J., He, L., Dinger, B. and Fidone, S. (2000) Cellular mechanisms involved in rabbit carotid body excitation elicited by endothelin peptides. Resp. Physiol. 121, 13–23.
Howard, L.S. and Robbins, P.A. (1995). Alterations in respiratory control during 8 hr of isocapnic and poikilocapnic hypoxia in humans. J. Appl. Physiol. 78, 1098–1107.
Howard, L.S., Barson, R.A, Howse, B.P., McGill, T.R, McIntyre, M.E., O’Connor, D.F. and Robbins, P.A. (1995). Chamber for controlling end-tidal gas tensions over sustained periods in humans. J. Appl. Physiol. 78, 1088–1091.
Kline, D.D., Peng, Y., Manalo, D.J., Semenza, G.L. and Prabhaker, N.R. (2002) Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1y. PNAS 99, 821–826.
Smith, T.G., Brooks, J.T., Balanos, G.M., Lappin, T.R., Layton, D.M., Leedham, D.L., Liu, C., Maxwell, P.H., McMullin, M.F., McNamara, C.J., Percy, M.L., Pugh, C.W., Ratcliffe, P.J., Talbot, N.P., Treacy, M. and Robbins, P.A. (2006) Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med. 3(7), e290.
Yamashita, K., Discher, D.J, Hu, J. Bishopric, N.H. and Webster, K.A. (2001) Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2 and p300/CBP. J. Biol. Chem. 276, 12645–12653.
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Talbot, N.P., Balanos, G.M., Robbins, P.A., Dorrington, K.L. (2008). Intravenous Endothelin-1 and Ventilatory Sensitivity to Hypoxia in Humans. In: Poulin, M.J., Wilson, R.J.A. (eds) Integration in Respiratory Control. Advances in Experimental Medicine and Biology, vol 605. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73693-8_10
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DOI: https://doi.org/10.1007/978-0-387-73693-8_10
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