History of Measuring O2 and CO2 Responses

  • John W. Severinghaus
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

Quantitative analysis of the chemical interactions of CO2 and O2 on ventilation from early 20th century to the present start with the amazingly steep CO2 response found by Haldane and his pupils, proceed through discovery of the prime role of the H+ ion and the discovery of carotid body chemoreception. The interaction of central and peripheral drives and changes with time and acute and chronic altitude exposure are still under investigation.


Carotid Body Ventilatory Response Hypoxic Ventilatory Response Hyperbolic Asymptote Carotid Body Chemoreception 
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Copyright information

© Springer 2008

Authors and Affiliations

  • John W. Severinghaus
    • 1
  1. 1.Department of AnesthesiaUniversity of California San FranciscoSan FranciscoUSA

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