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1,3,5-Triazepan-2,6-diones as Conformationally Constrained Dipeptide Mimetics. In Silico Guided Identification of sPLA2 Inhibitors

  • Gilles Guichard
  • Gersande Léna
  • Joel Boeglin
  • Pascal Muller
  • Eric Boilard
  • Gérard Lambeau
  • Didier Rognan
  • Claude Didierjean
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Keywords

Chain Carboxylic Acid Micromolar Affinity Predicted Binding Mode Urea Carbonyl sPLA2 Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This research was supported in part by Centre National de la recherche Scientifique (CNRS), Région Alsace and ImmuPharma France. CIFRE fellowships from ImmuPharma France and the Association Nationale pour la Recherche Technique (ANRT) for G.L. and J.B. are gratefully acknowledged.

References

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Gilles Guichard
    • 1
  • Gersande Léna
    • 1
  • Joel Boeglin
    • 1
  • Pascal Muller
    • 2
  • Eric Boilard
    • 3
  • Gérard Lambeau
    • 3
  • Didier Rognan
    • 2
  • Claude Didierjean
    • 4
  1. 1.Institut de Biologie Moléculaire et CellulaireCNRSStrasbourgFrance
  2. 2.Bioinformatique du médicamentCNRSIllkirchFrance
  3. 3.Institut de Pharmacologie Moléculaire et cellulaireCNRSValbonneFrance
  4. 4.LCM3B groupe BiocristallographieUniversité Henri Poincaré, CNRSVandoeuvreFrance

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