Synthetic Peptide Vaccines: The Quest to Develop Peptide Vaccines for Influenza, HIV and Alzheimer's Disease
The idea that the perfect vaccine would be of total synthetic making, composed only of chemically unambiguous material, dates back to the early ′80s [1,2]. However, despite considerable advances in both our understanding of the triggers of a protective immune response, and our ability to assemble increasingly complex macromolecular structures, no such vaccine has yet been approved for human use. Indeed, the initial enthusiasm has later been substituted by the prevailing belief that synthetic peptide vaccines are not possible.
In our laboratories we have been working towards this goal for a number of years, and we will highlight here some of our efforts to develop synthetic peptide vaccines for Alzheimer's disease (AD), HIV virus, and influenza virus. Our vaccines are aimed at eliciting a protective antibody response, and are based on chemically synthesized peptides corresponding to key protective B-cell epitopes, either used as such or conjugated to a protein carrier. The...
KeywordsNeisseria Meningitidis Phage Antibody Library Synthetic Peptide Vaccine Expose Surface Loop Viral Membrane Protein
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