Peptide Ligation via the In-Situ Transformation of an Amide into a Thioester at a Cysteine Residue

  • Toru Kawakami
  • Saburo Aimoto
Part of the Advances in Experimental Medicine and Biology book series (volume 611)


Trifluoroacetic Acid Solid Phase Peptide Synthesis Trifluoromethanesulfonic Acid Ligation Site Sodium Bicarbonate Buffer 
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This research was supported, in part, by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan.


  1. 1.
    Hojo, H., Aimoto, S. Bull. Chem. Soc. Jpn. 64, 111–117 (1991).CrossRefGoogle Scholar
  2. 2.
    Dawson, P. E., Muir, T. W., Clark-Lewis, I., Kent, S. B. H. Science 266, 776–779 (1994).CrossRefGoogle Scholar
  3. 3.
    Nakamura, K., Sumida, M., Kawakami, T., Vorherr, T., Aimoto, S., Bull. Chem. Soc. Jpn. 79, 1773–1780 (2006).CrossRefGoogle Scholar
  4. 4.
    Zanotti, G., Pinnen, F., Lucente, G. Tetrahedron Lett. 26, 5481–5464 (1985).CrossRefGoogle Scholar
  5. 5.
    Kawakami, T., Aimoto, S. Chem. Lett. 36, 76– 77 (2007).CrossRefGoogle Scholar
  6. 6.
    Kawakami, T., Aimoto, S. Tetrahedron Lett. 48, 1903–1905 (2007).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Toru Kawakami
    • 1
  • Saburo Aimoto
    • 1
  1. 1.Institute for Protein ResearchOsaka UniversitySuitaJapan

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