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Introduction of N-alkyl Residues in Proline-rich Peptides: Effect on SH3 Binding Affinity and Peptide Conformation

  • Paolo Ruzza
  • Chiara Rubini
  • Giuliano Siligardi
  • Rohanah Hussain
  • Andrea Calderan
  • Andrea Guiotto
  • Luca Cesaro
  • Anna M. Brunati
  • Arianna Donella-Deana
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Keywords

Conformational Property Proline Residue Pipecolic Acid Helix Conformation Peptide Binding Affinity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Nguyen, J.T., et al. Science 282, 2088–2092 (1998).CrossRefGoogle Scholar
  2. 2.
    Siligardi, G., et al. J. Biol. Chem. 277, 20151–20159 (2002).CrossRefGoogle Scholar
  3. 3.
    Goodman, M. and Fried, M. J. Am. Chem. Soc. 89, 1264–1267 (1967).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Paolo Ruzza
    • 1
  • Chiara Rubini
    • 1
  • Giuliano Siligardi
    • 2
  • Rohanah Hussain
    • 2
  • Andrea Calderan
    • 1
  • Andrea Guiotto
    • 1
  • Luca Cesaro
    • 3
  • Anna M. Brunati
    • 3
  • Arianna Donella-Deana
    • 3
  1. 1.Padua UnitCNR Institute of Biomolecular ChemistryPaduaItaly
  2. 2.Diamond Light Source, Diamond House ChiltonOxfordshireUK
  3. 3.Department of Biological ChemistryUniversity of PaduaPaduaItaly

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