Injectable Biodegradable Polymer Depots For Minimally Invasive Delivery of Peptides and Proteins
With hundreds of biotechnological drugs, mostly peptides and proteins, undergoing clinical trials, there is an urgent need for improved methods to deliver these magnificent biomacromolecules. Unfortunately, when administered to the body by noninvasive routes, most of peptide and protein drugs suffer from significant biological barriers such as poor drug permeability across intestinal mucosa and susceptibility to proteolysis, which in turn, prevents the drug from reaching the systemic circulation and the desired pharmacological target. Therefore, this class of drug molecules is most commonly delivered by injection (e.g., subcutaneously (s.c.) or intravenously (i.v.)) allowing immediate (i.v.) or easy (s.c.) access to the blood circulation. However, even when administered i.v., the body normally eliminates the drug rapidly, requiring the drug be injected repeatedly (e.g., multiple times a day or week). Frequent injections often result in significant pain, poor patient...
KeywordsPeptide Antigen Central Precocious Puberty Leuprolide Acetate Polymer Control Group Laser Doppler Perfusion Imaging
The contributions of many former students (particularly C. Cui and Y. Zhong) and collaborators (particularly V. Stevens, S. R. Mallery, and D. Mooney) in the research described here are gratefully acknowledged.
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