Advertisement

Injectable Biodegradable Polymer Depots For Minimally Invasive Delivery of Peptides and Proteins

  • Li Zhang
  • Steven P. Schwendeman
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

With hundreds of biotechnological drugs, mostly peptides and proteins, undergoing clinical trials, there is an urgent need for improved methods to deliver these magnificent biomacromolecules. Unfortunately, when administered to the body by noninvasive routes, most of peptide and protein drugs suffer from significant biological barriers such as poor drug permeability across intestinal mucosa and susceptibility to proteolysis, which in turn, prevents the drug from reaching the systemic circulation and the desired pharmacological target. Therefore, this class of drug molecules is most commonly delivered by injection (e.g., subcutaneously (s.c.) or intravenously (i.v.)) allowing immediate (i.v.) or easy (s.c.) access to the blood circulation. However, even when administered i.v., the body normally eliminates the drug rapidly, requiring the drug be injected repeatedly (e.g., multiple times a day or week). Frequent injections often result in significant pain, poor patient...

Keywords

Peptide Antigen Central Precocious Puberty Leuprolide Acetate Polymer Control Group Laser Doppler Perfusion Imaging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The contributions of many former students (particularly C. Cui and Y. Zhong) and collaborators (particularly V. Stevens, S. R. Mallery, and D. Mooney) in the research described here are gratefully acknowledged.

References

  1. 1.
  2. 2.
  3. 3.
  4. 4.
    Zhu, G., Mallery, S. R. and Schwendeman, S. P. Nat. Biotech., 18, 52–57 (2000).CrossRefGoogle Scholar
  5. 5.
    Zhong, Y., et al. J. Control. Release, in press.Google Scholar
  6. 6.
    Cui, C., Stevens, V. C. and Schwendeman, S. P. Vaccine, 25, 500–509 (2007).CrossRefGoogle Scholar
  7. 7.
    Ding, A. G., Shenderova, A. and Schwendeman, S. P. J. Am. Chem. Soc., 128, 5384–5390 (2006).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Li Zhang
    • 1
  • Steven P. Schwendeman
    • 1
  1. 1.Department of Pharmaceutical SciencesUniversity of MichiganAnn ArborUSA

Personalised recommendations