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Supramolecular Aggregates derivatized by CCK8 Peptide as Selective Nanocarriers for Drug Delivery

  • Antonella Accardo
  • Diego Tesauro
  • Giancarlo Morelli
  • Luigi Del Pozzo
  • Carlo Pedone
  • Anna Lucia Tornesello
  • Ettore Benedetti
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

In last years the supramolecular aggregates became very versatile tools in biology, biochemistry and medicine for a large number of applications, first of all as drugs carriers [ 1, 2]. Unfortunately, many drugs often have a very narrow therapeutic window, meaning that the therapeutic concentration is not much lower than the toxic one. In several cases the toxicity can be reduced or the efficacy enhanced by the use of an appropriate drug carrier which changes the temporal and spatial distribution of the drug, i.e. its pharmacokinetic and biodistribution. A challenging objective would be to deliver to a tissue of interest large quantities of therapeutic agents by using peptide containing supramolecular nanovectors, such as micelles or vesicles [ 3, 4]. The aim of this project is to formulate mixed supramolecular aggregates capable to vehicle drugs on receptors overexpressed in human tumors. The mixed aggregates are formed by two amphipilic monomers. Both molecules have the...

Keywords

Dynamic Light Scattering Solid Phase Peptide Synthesis Supramolecular Aggregate Nuclear Medicine Technique Cholecystokinin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors thank the European Molecular Imaging Laboratories Network (EMIL) for financial support.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Antonella Accardo
    • 1
  • Diego Tesauro
    • 1
  • Giancarlo Morelli
    • 1
  • Luigi Del Pozzo
    • 1
  • Carlo Pedone
    • 1
  • Anna Lucia Tornesello
    • 1
  • Ettore Benedetti
    • 1
  1. 1.Department of Biological Sciences & Interuniversitary Center for Research on Bioactive Peptides (CIRPeB)University of Naples Federico II and IBB-CNRNapoliItaly

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