Bicyclic Organo-Peptides as Models for Carbohydrate Binding Proteins
Carbohydrate recognition is one of the most sophisticated recognition processes in biological systems.1This process mediates many important aspects of cell-cell recognition, such as inflammation, cell differentiation, tumor cell colonization and metastasis. However, due to its complexity and weak binding affinities, carbohydrate recognition by natural systems is still poorly understood. On the other hand, studies on synthetic carbohydrate receptors could make significant contributions to a better understanding of this process and lead to the development of new therapeutics. Given the importance of the carbohydrate recognition, it is not surprising that design and synthesis of artificial receptors for these important biological substrates attracted a great deal of attention in biomimetic chemistry. Current efforts are mainly focused on design of the receptors for complexation of monosacharides or short oligosaccharides.2This crude simplification has been based on the...
KeywordsReceptor Molecule Carbohydrate Binding Protein Carbohydrate Binding Site Artificial Receptor Lectin Binding Site
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