Advertisement

GHRP-2 Attenuates Burn-Induced Dysfunctions in Rodents

  • Ambikaipakan Balasubramaniam
  • Rashika Joshi
  • Lou Ann Friend
  • J. Howard James
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

After major burn injury, enhanced production of catabolic hormones and inflammatory cytokines and reduced levels of anabolic hormones result in prolonged hypermetabolism, loss of lean body mass and muscle wasting. Various treatments, including exercise and anabolic hormones such as insulin, growth hormone (GH), IGF-I or steroids, have been proposed or employed to reduce debilitating body protein loss, but they are far from satisfactory. Recently, we have shown that the newly isolated anti-cachectic peptide, ghrelin, is down regulated in rats after burn injury, and that exogenous ghrelin restores lost body weight by increasing food intake and enhancing adiposity in mice [1, 2]. Furthermore, ghrelin also significantly attenuated skeletal muscle protein breakdown in rats with burn injury by normalizing muscle mRNA expression of E3 ubiquitin ligases, MuRF1 and MAFbx [3, 4]. However, ghrelin's short half-life may limit its clinical application. Moreover, our ultimate goal is...

Keywords

Growth Hormone Extensor Digitorum Longus Increase Food Intake Anabolic Hormone Sham Procedure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The work was funded by a grant (#8570) from Shriners Hospitals for Children.

References

  1. 1.
    Balasubramaniam, A., et al. Peptides 27, 1624–1631 (2006).CrossRefGoogle Scholar
  2. 2.
    Balasubramaniam, A., et al. J. Burn Care & Res. 26, S108 (2005).Google Scholar
  3. 3.
    James, J. H., et al.. J. Burn Care Rehab. 26, S107 (2005).CrossRefGoogle Scholar
  4. 4.
    Joshi, R., et al. J Burn Care & Res 27, S164 (2006).CrossRefGoogle Scholar
  5. 5.
    Granado, M., et al. Am. J. Physiol. Endocrinol. Metab. 288, 486–492 (2005).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ambikaipakan Balasubramaniam
    • 1
  • Rashika Joshi
    • 1
  • Lou Ann Friend
    • 1
  • J. Howard James
    • 1
  1. 1.Department of SurgeryUniversity of Cincinnati Medical Center and Shriners Hospital for ChildrenCincinnatiUSA

Personalised recommendations