GHRP-2 Attenuates Burn-Induced Dysfunctions in Rodents
After major burn injury, enhanced production of catabolic hormones and inflammatory cytokines and reduced levels of anabolic hormones result in prolonged hypermetabolism, loss of lean body mass and muscle wasting. Various treatments, including exercise and anabolic hormones such as insulin, growth hormone (GH), IGF-I or steroids, have been proposed or employed to reduce debilitating body protein loss, but they are far from satisfactory. Recently, we have shown that the newly isolated anti-cachectic peptide, ghrelin, is down regulated in rats after burn injury, and that exogenous ghrelin restores lost body weight by increasing food intake and enhancing adiposity in mice [1, 2]. Furthermore, ghrelin also significantly attenuated skeletal muscle protein breakdown in rats with burn injury by normalizing muscle mRNA expression of E3 ubiquitin ligases, MuRF1 and MAFbx [3, 4]. However, ghrelin's short half-life may limit its clinical application. Moreover, our ultimate goal is...
KeywordsGrowth Hormone Extensor Digitorum Longus Increase Food Intake Anabolic Hormone Sham Procedure
The work was funded by a grant (#8570) from Shriners Hospitals for Children.
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