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Self-association regions in the CARD of Bcl-10

  • M. Ruvo
  • A. Sandomenico
  • D. Marasco
  • S. M. Monti
  • B. Tizzano
  • A. De Capua
  • C. Pedone
  • A. Saporito
  • R. M. Vitale
  • S. Formisano
  • R. Stilo
  • D. Liguoro
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

Many apoptotic signals are mediated by the association of proteins containing homologous domains, such as death domains (DD), death effector domains (DED), and caspase recruitment domains (CARD). Several CARD-containing proteins appear now to be directly involved in modulation of nuclear factor-kB (NF-kB) [1] and in the regulation of inflammatory responses and apoptosis. Among these, Bcl-10 (apoptosis regulator B-cell lymphoma 10) is one of the best studied for its correlation with MALT lymphomas [2, 3] and more recently as a downstream effector of lymphocyte antigen receptors to promote the activation of the IkappaB kinase complex leading to the phosphorylation and degradation of IkappaB [2]. Bcl-10 has a bipartite structure consisting of an N-terminal CARD domain and a C-terminal serine-threonine rich domain acting as a regulatory unit that undergoes multiple phosphorylation by several kinases. Most activities of Bcl-10 are accomplished by a dimeric form of the protein;...

Keywords

Malt Lymphoma Longe Fragment Death Effector Domain Caspase Recruitment Domain Card Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The support of project FIRB RBNE03PX83_005 is acknowledged.

References

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    Park H.H., et al., Annu. Rev. Immunol. 25, 561–86 (2007).CrossRefGoogle Scholar
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    Johnson, J. C. S. Prog. Nucl. Magn. Reson. Spectrosc. 34, 203–256 (1999).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • M. Ruvo
    • 1
  • A. Sandomenico
    • 1
  • D. Marasco
    • 1
  • S. M. Monti
    • 1
  • B. Tizzano
    • 1
  • A. De Capua
    • 1
  • C. Pedone
    • 1
  • A. Saporito
    • 1
  • R. M. Vitale
    • 1
  • S. Formisano
    • 2
  • R. Stilo
    • 3
  • D. Liguoro
    • 4
  1. 1.IBB-CNR — via MezzocannoneNapoli-Italy
  2. 2.Universita degli Studi di Napoli Federico IINapoli-Italy
  3. 3.Universita degli Studi del Sannio di BeneventoBenevent-Italy
  4. 4.IEOS-CNRNapoli-Italy

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