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Synthesis of Biotin-Tagged Diketopiperazine-Based Anti-Microtubule Agents and Tubulin Photoaffinity Labeling

  • Yuri Yamazaki
  • Kyoko Kohno
  • Hiroyuki Yasui
  • Yoshiaki Kiso
  • Saskia Neuteboom
  • Ana M. Barral
  • Barbara Potts
  • G. Kenneth Lloyd
  • Yoshio Hayashi
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Keywords

Vinca Alkaloid Human Colon Cancer Cell Line Microtubule Depolymerization Photoaffinity Label Potent Cytotoxic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This research was supported by various grants from MEXT (Ministry of Education, Culture, Sports, Science and Technology), Japan, including the 21st Century COE Program.

References

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    Kanoh, K., Kohno, S., Katada, J., Hayashi, Y., Muramatsu M., and Uno, I. Biosci. Biotechnol. Biochem., 63, 1130–1133 (1999).CrossRefGoogle Scholar
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    Kanoh, K., Kohno, S., Katada, J., Takahashi, J., Uno, I., and Hayashi, Y. Bioorg. Med. Chem., 7, 1451–1457 (1999).CrossRefGoogle Scholar
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    Hayashi, Y., Orikasa, S., Tanaka, K., Kanoh, K., and Kiso, Y. J. Org. Chem., 65, 8402– 8405 (2000).CrossRefGoogle Scholar
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    Nicholson, B., Lloyd, G. K., Miller, B. R., Palladino, M. A., Kiso, Y., Hayashi, Y., and Neuteboom, S. T. C. Anti-Cancer Drugs, 17, 25–31 (2006).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Yuri Yamazaki
    • 1
    • 4
  • Kyoko Kohno
    • 2
  • Hiroyuki Yasui
    • 3
  • Yoshiaki Kiso
    • 1
  • Saskia Neuteboom
    • 5
  • Ana M. Barral
    • 5
  • Barbara Potts
    • 5
  • G. Kenneth Lloyd
    • 5
  • Yoshio Hayashi
    • 1
    • 4
  1. 1.Department of Medicinal ChemistryKyoto Pharmaceutical UniversityYamashina-kuJapan
  2. 2.Department of Molecular GeneticsKyoto Pharmaceutical UniversityYamashina-kuJapan
  3. 3.Department of Analytical and Bioinorganic ChemistryKyoto Pharmaceutical UniversityYamashina-kuJapan
  4. 4.Department of Medicinal Chemistry, School of Pharmacy, TokyoUniversity of Pharmacy and Life SciencesHachiojiJapan
  5. 5.Nereus PharmaceuticalsSan DiegoUSA

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