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Molecular Modeling Approach to Achieving Erythropoietin Mimetic Peptides

  • Yanfeng Qi
  • Xuefeng Gao
  • Liping Wang
  • Wei Li
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

Erythropoietin (EPO) is a 34 kDa glycoprotein which regulates the production of red blood cells. Deficits in EPO production result in anemia in human, the most prevalent form of anemia is associated with kidney failure. At present, the only treatment for this form of anemia is administration of recombinant EPO via subcutaneous or intravenous injection. The use of recombinant EPO has significantly improved the quality of life of these patients; however, this treatment requires repeated administration of recombinant protein, which is both inconvenient and expensive. Finding small molecules and peptides to alternative EPO, change the administration route of EPO is very popular in recent years.

The crystal structures of EPO-EPOR and small peptide agonist (EMP-1)-EPOR complexes have been solved and reveal a different configuration of the EPOR dimer in each of the complexes [ 1, 2]. Through(By) analysis the structure data of these complex, Wilson etc propose that there's a...

Keywords

Protein Data Bank Code Negative Potential Region Molecular Dynamic Simulation Method Molecular Modeling Method Individual Amino Acid Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Livnah O., et al. Science, 273, 464–471 (1996). CrossRefGoogle Scholar
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    Wrighton NC, et al. Science, 273, 458–463 (1996).CrossRefGoogle Scholar
  3. 3.
    Ian A Wilson et al. Current Opinion in Structural Biology 9, 696–704 (1999).CrossRefGoogle Scholar
  4. 4.
    Lindahl, E., Hess, B. and van der Spoel, D. J. Mol. Mod., 7, 306–317 (2001).Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Yanfeng Qi
  • Xuefeng Gao
    • 1
  • Liping Wang
  • Wei Li
  1. 1.Edmond H. Fischer Cellular Signal Transduction Lab, College of Life ScienceJilin UniversityChangchunChina

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