Molecular Modeling Approach to Achieving Erythropoietin Mimetic Peptides
Erythropoietin (EPO) is a 34 kDa glycoprotein which regulates the production of red blood cells. Deficits in EPO production result in anemia in human, the most prevalent form of anemia is associated with kidney failure. At present, the only treatment for this form of anemia is administration of recombinant EPO via subcutaneous or intravenous injection. The use of recombinant EPO has significantly improved the quality of life of these patients; however, this treatment requires repeated administration of recombinant protein, which is both inconvenient and expensive. Finding small molecules and peptides to alternative EPO, change the administration route of EPO is very popular in recent years.
KeywordsProtein Data Bank Code Negative Potential Region Molecular Dynamic Simulation Method Molecular Modeling Method Individual Amino Acid Residue
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