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Synthesis and Structure-based Dissection of Cyclic Peptide Chitinase Inhibitors: New Leads for Antifungal and Anti-Inflammatory Drugs

  • Mark J. Dixon
  • Amit Nathubhai
  • Ole A. Andersen
  • Daan M. F. van Aalten
  • Ian M. Eggleston
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Keywords

Cyclic Peptide Catalytic Residue Bioactive Conformation Fungal Chitinase Lipid Storage Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank the Wellcome Trust and the Biotechnology and Biological Sciences Research Council for financial support.

References

  1. 1.
    Andersen, O. A., Dixon, M. J., Eggleston, I. M., van Aalten, D. M. F. Nat. Prod. Rep. 22, 563–569 (2005).CrossRefGoogle Scholar
  2. 2.
    Dixon, M. J., Andersen, O. A., van Aalten, D. M. F., Eggleston, I. M. Bioorg. Med. Chem. Lett. 15, 4717–4721 (2005).CrossRefGoogle Scholar
  3. 3.
    Dixon, M. J., Andersen, O. A., van Aalten, D. M. F., Eggleston, I. M. Eur. J. Org. Chem. 24, 5002–5006 (2006).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Mark J. Dixon
    • 1
  • Amit Nathubhai
    • 1
  • Ole A. Andersen
    • 2
  • Daan M. F. van Aalten
    • 2
  • Ian M. Eggleston
    • 1
  1. 1.Department of Pharmacy and PharmacologyUniversity of BathBathUK
  2. 2.Division of Biological Chemistry and Drug Discovery, College of Life SciencesUniversity of DundeeDundeeUK

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